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+ and CD8- Dendritic Cells to Prime Th1/Th2 Cells In Vivo1
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Institut de Biologie et Médecine Moléculaires, Université Libre de Bruxelles, Gosselies, Belgium; and
Immunex Corporation, Seattle, WA 98101
Prior studies have shown that subclasses of dendritic cells (DC)
direct the development of distinct Th populations in rodents and in
humans. In the mouse, we have recently shown that administration of
Ag-pulsed CD8
- DC induces a Th2-type response, whereas
injection of CD8+ DC leads to Th1 differentiation. To
define the DC-derived factors involved in the polarization of Th
responses, we injected either subset purified from mice genetically
deficient for IFN-
, IL-4, IL-12, or IL-10 into wild-type animals. In
this work, we report that DC-derived IL-12 and IFN- are required for
Th1 priming by CD8+ DC, whereas IL-10 is required for
optimal development of Th2 cells by CD8- DC. The level
of IL-12 produced by the DC appears to determine the Th1/Th2 balance in
vivo. We further show that the function of DC subsets displays some
flexibility. Treatment of DC with IL-10 in vitro induces a selective
decrease in the viability of CD8+ DC. Conversely,
incubation with IFN- down-regulates the Th2-promoting capacities of
CD8- DC and increases the Th1-skewing properties of
both subsets.
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U. Yrlid and M. J. Wick Antigen Presentation Capacity and Cytokine Production by Murine Splenic Dendritic Cell Subsets upon Salmonella Encounter J. Immunol., July 1, 2002; 169(1): 108 - 116. [Abstract] [Full Text] [PDF]
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E. Muraille, C. De Trez, B. Pajak, M. Brait, J. Urbain, and O. Leo T Cell-Dependent Maturation of Dendritic Cells in Response to Bacterial Superantigens J. Immunol., May 1, 2002; 168(9): 4352 - 4360. [Abstract] [Full Text] [PDF]
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J. Shaw, V. Grund, L. Durling, D. Crane, and H. D. Caldwell Dendritic Cells Pulsed with a Recombinant Chlamydial Major Outer Membrane Protein Antigen Elicit a CD4+ Type 2 Rather than Type 1 Immune Response That Is Not Protective Infect. Immun., March 1, 2002; 70(3): 1097 - 1105. [Abstract] [Full Text] [PDF]
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