| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Microbiology, University of Tennessee, Knoxville, TN 37996
Neonatal exposure to Ag has always been considered suppressive for immunity. Recent investigations, however, indicated that the neonatal immune system could be guided to develop immunity. For instance, delivery of a proteolipid protein (PLP) peptide on Ig boosts the neonatal immune system to develop responses upon challenge with the PLP peptide later. Accordingly, mice given Ig-PLP at birth and challenged with the PLP peptide as adults developed proliferative T cells in the lymph node that produced IL-4 instead of the usual Th1 cytokines. However, the spleen was unresponsive unless IL-12 was provided. Herein, we wished to determine whether such a neonatal response is intrinsic to the PLP peptide or could develop with an unrelated myelin peptide as well as whether the T cell deviation is able to confer resistance to autoimmunity involving diverse T cell specificities. Accordingly, the amino acid sequence 87–99 of myelin basic protein was expressed on the same Ig backbone, and the resulting Ig-myelin basic protein chimera was tested for induction of neonatal immunity and protection against experimental allergic encephalomyelitis. Surprisingly, the results indicated that immunity developed in the lymph node and spleen, with deviation of T cells occurring in both organs. More striking, the splenic T cells produced IL-10 in addition to IL-4, providing an environment that facilitated bystander deviation of responses to unrelated epitopes and promoted protection against experimental allergic encephalomyelitis involving diverse T cell specificities. Thus, neonatal exposure to Ag can prime responses in various organs and sustain regulatory functions effective against diverse autoreactive T cells.
This article has been cited by other articles:
|
|
 |
|
  D. You, M. Ripple, S. Balakrishna, D. Troxclair, D. Sandquist, L. Ding, T. A. Ahlert, and S. A. Cormier Inchoate CD8+ T Cell Responses in Neonatal Mice Permit Influenza-Induced Persistent Pulmonary Dysfunction J. Immunol., September 1, 2008; 181(5): 3486 - 3494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bell, R. D. Divekar, J. S. Ellis, J. A. Cascio, C. L. Haymaker, R. Jain, D. M. Tartar, C. M. Hoeman, J. C. Hardaway, and H. Zaghouani In Trans T Cell Tolerance Diminishes Autoantibody Responses and Exacerbates Experimental Allergic Encephalomyelitis J. Immunol., February 1, 2008; 180(3): 1508 - 1516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Caprio-Young, J. J. Bell, H.-H. Lee, J. Ellis, D. Nast, G. Sayler, B. Min, and H. Zaghouani Neonatally Primed Lymph Node, but Not Splenic T Cells, Display a Gly-Gly Motif within the TCR {beta}-Chain Complementarity-Determining Region 3 That Controls Affinity and May Affect Lymphoid Organ Retention J. Immunol., January 1, 2006; 176(1): 357 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Yu, R. K. Gregg, J. J. Bell, J. S. Ellis, R. Divekar, H.-H. Lee, R. Jain, H. Waldner, J. C. Hardaway, M. Collins, et al. Specific T Regulatory Cells Display Broad Suppressive Functions against Experimental Allergic Encephalomyelitis upon Activation with Cognate Antigen J. Immunol., June 1, 2005; 174(11): 6772 - 6780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bailey, K. Haverson, B. Miller, P. Jones, I. Sola, L. Enjuanes, and C. R. Stokes Effects of Infection with Transmissible Gastroenteritis Virus on Concomitant Immune Responses to Dietary and Injected Antigens Clin. Vaccine Immunol., March 1, 2004; 11(2): 337 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bell, B. Min, R. K. Gregg, H.-H. Lee, and H. Zaghouani Break of Neonatal Th1 Tolerance and Exacerbation of Experimental Allergic Encephalomyelitis by Interference with B7 Costimulation J. Immunol., August 15, 2003; 171(4): 1801 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Field, L. Caccavelli, M.-F. Bloch, and B. Bellon Regulatory CD8+ T Cells Control Neonatal Tolerance to a Th2-Mediated Autoimmunity J. Immunol., March 1, 2003; 170(5): 2508 - 2515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kipnis, T. Mizrahi, E. Hauben, I. Shaked, E. Shevach, and M. Schwartz Neuroprotective autoimmunity: Naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system PNAS, November 26, 2002; 99(24): 15620 - 15625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Adkins, Y. Bu, and P. Guevara Murine Neonatal CD4+ Lymph Node Cells Are Highly Deficient in the Development of Antigen-Specific Th1 Function in Adoptive Adult Hosts J. Immunol., November 1, 2002; 169(9): 4998 - 5004. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
