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Cutting Edge |
,
,
Departments of
*
Medicine and Biochemistry,
Surgery, and
Microbiology and Immunology, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202; and
Walther Cancer Institute, Indianapolis, IN 46206
A novel secreted cytokine, termed IL-17F, was cloned using
nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was
expressed only in activated CD4+ T cells and activated
monocytes. Recombinant human IL-17F did not stimulate the proliferation
of hematopoietic progenitors or the migration of mature leukocytes.
However, it markedly inhibited the angiogenesis of human endothelial
cells and induced endothelial cells to produce IL-2, TGF-
, and
monocyte chemoattractant protein-1.
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