The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wipasa, J.
Right arrow Articles by Good, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wipasa, J.
Right arrow Articles by Good, M. F.
The Journal of Immunology, 2001, 167: 3903-3909.
Copyright © 2001 by The American Association of Immunologists

Apoptotic Deletion of Th Cells Specific for the 19-kDa Carboxyl-Terminal Fragment of Merozoite Surface Protein 1 During Malaria Infection1

Jiraprapa Wipasa*, Huji Xu*, Anthony Stowers{dagger} and Michael F. Good2,*

* Cooperative Research Center for Vaccine Technology, Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Australia; and {dagger} Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

Immunity induced by the 19-kDa fragment of merozoite surface protein 1 is dependent on CD4+ Th cells. However, we found that adoptively transferred CFSE-labeled Th cells specific for an epitope on Plasmodium yoelii 19-kDa fragment of merozoite surface protein 1 (peptide (p)24), but not OVA-specific T cells, were deleted as a result of P. yoelii infection. As a result of infection, spleen cells recovered from infected p24-specific T cell-transfused mice demonstrated reduced response to specific Ag. A higher percentage of CFSE-labeled p24-specific T cells stained positive with annexin and anti-active caspase-3 in infected compared with uninfected mice, suggesting that apoptosis contributed to deletion of p24-specific T cells during infection. Apoptosis correlated with increased percentages of p24-specific T cells that stained positive for Fas from infected mice, suggesting that P. yoelii-induced apoptosis is, at least in part, mediated by Fas. However, bystander cells of other specificities also showed increased Fas expression during infection, suggesting that Fas expression alone is not sufficient for apoptosis. These data have implications for the development of immunity in the face of endemic parasite exposure.




This article has been cited by other articles:


Home page
 Infect. Immun.Home page
J. Wipasa, H. Xu, X. Liu, C. Hirunpetcharat, A. Stowers, and M. F. Good
Effect of Plasmodium yoelii Exposure on Vaccination with the 19-Kilodalton Carboxyl Terminus of Merozoite Surface Protein 1 and Vice Versa and Implications for the Application of a Human Malaria Vaccine
Infect. Immun., February 1, 2009; 77(2): 817 - 824.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. P. Freitas do Rosario, S. M. Muxel, S. M. Rodriguez-Malaga, L. R. Sardinha, C. A. Zago, S. I. Castillo-Mendez, J. M. Alvarez, and M. R. D'Imperio Lima
Gradual Decline in Malaria-Specific Memory T Cell Responses Leads to Failure to Maintain Long-Term Protective Immunity to Plasmodium chabaudi AS Despite Persistence of B Cell Memory and Circulating Antibody
J. Immunol., December 15, 2008; 181(12): 8344 - 8355.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. R. Elliott, T. P. Spurck, J. M. Dodin, A. G. Maier, T. S. Voss, F. Yosaatmadja, P. D. Payne, G. I. McFadden, A. F. Cowman, S. J. Rogerson, et al.
Inhibition of Dendritic Cell Maturation by Malaria Is Dose Dependent and Does Not Require Plasmodium falciparum Erythrocyte Membrane Protein 1
Infect. Immun., July 1, 2007; 75(7): 3621 - 3632.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
A. VALDERRAMA-AGUIRRE, G. QUINTERO, A. GOMEZ, A. CASTELLANOS, Y. PEREZ, F. MENDEZ, M. AREVALO-HERRERA, and S. HERRERA
ANTIGENICITY, IMMUNOGENICITY, AND PROTECTIVE EFFICACY OF PLASMODIUM VIVAX MSP1 PV200L: A POTENTIAL MALARIA VACCINE SUBUNIT
Am J Trop Med Hyg, November 1, 2005; 73(5_suppl): 16 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. HERRERA, A. GOMEZ, O. VERA, J. VERGARA, A. VALDERRAMA-AGUIRRE, A. MAESTRE, F. MENDEZ, R. WANG, C. E. CHITNIS, S. S. YAZDANI, et al.
ANTIBODY RESPONSE TO PLASMODIUM VIVAX ANTIGENS IN FY-NEGATIVE INDIVIDUALS FROM THE COLOMBIAN PACIFIC COAST
Am J Trop Med Hyg, November 1, 2005; 73(5_suppl): 44 - 49.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Stephens, F. R. Albano, S. Quin, B. J. Pascal, V. Harrison, B. Stockinger, D. Kioussis, H.-U. Weltzien, and J. Langhorne
Malaria-specific transgenic CD4+ T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance
Blood, September 1, 2005; 106(5): 1676 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. N. Wykes, Y.-H. Zhou, X. Q. Liu, and M. F. Good
Plasmodium yoelii Can Ablate Vaccine-Induced Long-Term Protection in Mice
J. Immunol., August 15, 2005; 175(4): 2510 - 2516.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. C. Urban, T. T. Hien, N. P. Day, N. H. Phu, R. Roberts, E. Pongponratn, M. Jones, N. T. H. Mai, D. Bethell, G. D. H. Turner, et al.
Fatal Plasmodium falciparum Malaria Causes Specific Patterns of Splenic Architectural Disorganization
Infect. Immun., April 1, 2005; 73(4): 1986 - 1994.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. R. Elliott, R. D. Kuns, and M. F. Good
Heterologous Immunity in the Absence of Variant-Specific Antibodies after Exposure to Subpatent Infection with Blood-Stage Malaria
Infect. Immun., April 1, 2005; 73(4): 2478 - 2485.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
C. SUPHAVILAI, S. LOOAREESUWAN, and M. F. GOOD
ANALYSIS OF CIRCUMSPOROZOITE PROTEIN-SPECIFIC IMMUNE RESPONSES FOLLOWING RECENT INFECTION WITH PLASMODIUM VIVAX
Am J Trop Med Hyg, July 1, 2004; 71(1): 29 - 39.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. S. Struik, F. M. Omer, K. Artavanis-Tsakonas, and E. M. Riley
Uninfected erythrocytes inhibit Plasmodium falciparum-induced cellular immune responses in whole-blood assays
Blood, April 15, 2004; 103(8): 3084 - 3092.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. C. Gavrilescu and E. Y. Denkers
Apoptosis and the Balance of Homeostatic and Pathologic Responses to Protozoan Infection
Infect. Immun., November 1, 2003; 71(11): 6109 - 6115.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
L. I. Rutitzky, G. A. Mirkin, and M. J. Stadecker
Apoptosis by Neglect of CD4+ Th Cells in Granulomas: A Novel Effector Mechanism Involved in the Control of Egg-Induced Immunopathology in Murine Schistosomiasis
J. Immunol., August 15, 2003; 171(4): 1859 - 1867.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Wipasa, C. Hirunpetcharat, Y. Mahakunkijcharoen, H. Xu, S. Elliott, and M. F. Good
Identification of T Cell Epitopes on the 33-kDa Fragment of Plasmodium yoelii Merozoite Surface Protein 1 and Their Antibody-Independent Protective Role in Immunity to Blood Stage Malaria
J. Immunol., July 15, 2002; 169(2): 944 - 951.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H. Xu, J. Wipasa, H. Yan, M. Zeng, M. O. Makobongo, F. D. Finkelman, A. Kelso, and M. F. Good
The Mechanism and Significance of Deletion of Parasite-specific CD4+ T Cells in Malaria Infection
J. Exp. Med., April 1, 2002; 195(7): 881 - 892.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.