| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Producing CD4+ Mediastinal Lymph Node Cells Obtained from Mice Tracheally Tolerized to Ovalbumin (OVA) Suppress Both Th1- and Th2-Induced Cutaneous Inflammatory Responses to OVA by Different Mechanisms1
*
Department of Dermatology and
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
Advances in the treatment of allergic disorders require elucidation
of the autoregulatory immune systems induced in averting detrimental
inflammatory responses against invading foreign Ags. We previously
reported that excessive Ags intruding through the airway mucosa induce
a subset of regulatory CD4+ T cells secreting TGF-
in
the regional mediastinal lymph nodes (MLNs), which inhibits Th2 cells
and subsequent eosinophilic inflammation in the trachea. In the present
experiments we examined whether and in what mechanisms
TGF--secreting CD4+ T cells in the MLNs regulate Th
cell-mediated skin inflammation using a previously established murine
model. Th1 or Th2 cells injected s.c. into ear lobes of naive mice
induced swelling, whereas the concomitant local injection of MLN cells
suppressed the inflammation. The suppressor activities of MLN cells
were markedly neutralized by anti-TGF- mAb and were mimicked by
rTGF-. The MLN cell- and rTGF--induced inhibition was reversed by
anti-IL-10 mAb significantly in Th1-induced inflammation and only
partially in Th2-induced inflammation. rIL-10 reduced Th-induced ear
swelling, although higher doses of rIL-10 were required in Th2-induced
one. Thus, allergen-specific TGF--producing CD4+ T cells
induced in the respiratory tract controlled cutaneous inflammatory
responses by Th1 or Th2 cells either directly by TGF- or indirectly
through IL-10 induction. From a clinical standpoint, these observations
might explain the mechanism of spontaneous regression in some patients
with atopic dermatitis, which exhibits both Th1- and Th2-mediated skin
inflammation in response to airborne protein
Ags.
This article has been cited by other articles:
|
|
 |
|
  D. Alvarez, F. K. Swirski, T.-C. Yang, R. Fattouh, K. Croitoru, J. L. Bramson, M. R. Stampfli, and M. Jordana Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues J. Immunol., February 15, 2006; 176(4): 2568 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang-Hoover, P. Finn, and J. Stein-Streilein Modulation of Ovalbumin-Induced Airway Inflammation and Hyperreactivity by Tolerogenic APC J. Immunol., December 1, 2005; 175(11): 7117 - 7124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Aronica, S. McCarthy, S. Swaidani, D. Mitchell, M. Goral, J. R. Sheller, and M. Boothby Recall Helper T Cell Response: T Helper 1 Cell-resistant Allergic Susceptibility without Biasing Uncommitted CD4 T Cells Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 587 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Tiemessen, S. Kunzmann, C. B. Schmidt-Weber, J. Garssen, C. A. F. M. Bruijnzeel-Koomen, E. F. Knol, and E. Van Hoffen Transforming growth factor-{beta} inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response Int. Immunol., December 1, 2003; 15(12): 1495 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Horwitz, S. G. Zheng, and J. D. Gray The role of the combination of IL-2 and TGF-{beta} or IL-10 in the generation and function of CD4+ CD25+ and CD8+regulatory T cell subsets J. Leukoc. Biol., October 1, 2003; 74(4): 471 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grundstrom, L. Cederbom, A. Sundstedt, P. Scheipers, and F. Ivars Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4+CD25+ Regulatory T Cells In Vivo J. Immunol., May 15, 2003; 170(10): 5008 - 5017. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
