| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Is a Dominant Factor Directing T Cells into Murine Cardiac Allografts During Acute Rejection1
,
*
Urological Institute and
Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195;
Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, CA 90095; and
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106
The use of chemokine antagonism as a strategy to inhibit leukocyte
trafficking into inflammatory sites requires identification of the
dominant chemokines mediating recruitment. The chemokine(s) directing T
cells into cardiac allografts during acute rejection remain(s)
unidentified. The role of the CXC chemokines IFN-
inducible protein
10 (IP-10) and monokine induced by IFN- (Mig) in acute rejection of
A/J (H-2a) cardiac grafts by C57BL/6 (H-2b)
recipients was tested. Intra-allograft expression of Mig was observed
at day 2 posttransplant and increased to the time of rejection at day 7
posttransplant. IP-10 mRNA and protein production were 2.5- to 8-fold
lower than Mig. Whereas allografts were rejected at day 7–9 in control
recipients, treatment with rabbit antiserum to Mig, but not to IP-10,
prolonged allograft survival up to day 19 posttransplant. At day 7
posttransplant, allografts from Mig antiserum-treated recipients had
marked reduction in T cell infiltration. At the time of rejection in
Mig antiserum-treated recipients (i.e., days 17–19), intra-allograft
expression of macrophage-inflammatory protein-1
, -1
, and their
ligand CCR5 was high, whereas expression of CXCR3, the Mig receptor,
was virtually absent. Mig was produced by the allograft endothelium as
well as by recipient allograft-infiltrating macrophages and
neutrophils, indicating the synergistic interactions between innate and
adaptive immune compartments during acute rejection. Collectively,
these results indicate that Mig is a dominant recruiting factor for
alloantigen-primed T cells into cardiac allografts during acute
rejection. Although Mig antagonism delays acute heart allograft
rejection, the results also suggest that the alloimmune response
circumvents Mig antagonism through alternative
mechanisms.
This article has been cited by other articles:
|
|
 |
|
  J. A Belperio and A. Ardehali Chemokines and Transplant Vasculopathy Circ. Res., August 29, 2008; 103(5): 454 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Yolcu, X. Gu, C. Lacelle, H. Zhao, L. Bandura-Morgan, N. Askenasy, and H. Shirwan Induction of Tolerance to Cardiac Allografts Using Donor Splenocytes Engineered to Display on Their Surface an Exogenous Fas Ligand Protein J. Immunol., July 15, 2008; 181(2): 931 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhang, Y. K. Chan, B. Lu, M. S. Diamond, and R. S. Klein CXCR3 Mediates Region-Specific Antiviral T Cell Trafficking within the Central Nervous System during West Nile Virus Encephalitis J. Immunol., February 15, 2008; 180(4): 2641 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kwun, H. Hu, E. Schadde, D. Roenneburg, K. A. Sullivan, J. DeMartino, W. J. Burlingham, and S. J. Knechtle Altered Distribution of H60 Minor H Antigen-Specific CD8 T Cells and Attenuated Chronic Vasculopathy in Minor Histocompatibility Antigen Mismatched Heart Transplantation in Cxcr3 / Mouse Recipients J. Immunol., December 15, 2007; 179(12): 8016 - 8025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schroder, R. N. Pierson III, B.-N. H. Nguyen, D. W. Kawka, L. B. Peterson, G. Wu, T. Zhang, M. S. Springer, S. J. Siciliano, S. Iliff, et al. CCR5 Blockade Modulates Inflammation and Alloimmunity in Primates J. Immunol., August 15, 2007; 179(4): 2289 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Gorbachev, H. Kobayashi, D. Kudo, C. S. Tannenbaum, J. H. Finke, S. Shu, J. M. Farber, and R. L. Fairchild CXC Chemokine Ligand 9/Monokine Induced by IFN-{gamma} Production by Tumor Cells Is Critical for T Cell-Mediated Suppression of Cutaneous Tumors J. Immunol., February 15, 2007; 178(4): 2278 - 2286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Medoff, J. C. Wain, E. Seung, R. Jackobek, T. K. Means, L. C. Ginns, J. M. Farber, and A. D. Luster CXCR3 and Its Ligands in a Murine Model of Obliterative Bronchiolitis: Regulation and Function. J. Immunol., June 1, 2006; 176(11): 7087 - 7095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yuan, R. El-Asady, K. Liu, D. Wang, C. B. Drachenberg, and G. A. Hadley Critical Role for CD103+CD8+ Effectors in Promoting Tubular Injury following Allogeneic Renal Transplantation J. Immunol., September 1, 2005; 175(5): 2868 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanaka, R.-J. Swijnenburg, F. Gunawan, Y.-A. Cao, Y. Yang, A. D. Caffarelli, J. L. de Bruin, C. H. Contag, and R. C. Robbins In Vivo Visualization of Cardiac Allograft Rejection and Trafficking Passenger Leukocytes Using Bioluminescence Imaging Circulation, August 30, 2005; 112(9_suppl): I-105 - I-110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. El-Sawy, J. A. Belperio, R. M. Strieter, D. G. Remick, and R. L. Fairchild Inhibition of Polymorphonuclear Leukocyte-Mediated Graft Damage Synergizes With Short-Term Costimulatory Blockade to Prevent Cardiac Allograft Rejection Circulation, July 19, 2005; 112(3): 320 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. Hauser, S. Spiegler, E. Kiss, S. Gauer, O. Sichler, E. H. Scheuermann, H. Ackermann, J. M. Pfeilschifter, H. Geiger, H.-J. Grone, et al. Prediction of Acute Renal Allograft Rejection by Urinary Monokine Induced by IFN-{gamma} (MIG) J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1849 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Amano, A. Bickerstaff, C. G. Orosz, A. C. Novick, H. Toma, and R. L. Fairchild Absence of Recipient CCR5 Promotes Early and Increased Allospecific Antibody Responses to Cardiac Allografts J. Immunol., May 15, 2005; 174(10): 6499 - 6508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Singbartl, S. G.{b.}e Bockhorn, A. Zarbock, M. Schmolke, and H. Van Aken T Cells Modulate Neutrophil-Dependent Acute Renal Failure during Endotoxemia: Critical Role for CD28 J. Am. Soc. Nephrol., March 1, 2005; 16(3): 720 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanaka, S. Nakae, R. D. Terry, G. K. Mokhtari, F. Gunawan, L. B. Balsam, H. Kaneda, T. Kofidis, P. S. Tsao, and R. C. Robbins Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease Blood, December 1, 2004; 104(12): 3789 - 3796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Engeman, A. V. Gorbachev, D. D. Kish, and R. L. Fairchild The intensity of neutrophil infiltration controls the number of antigen-primed CD8 T cells recruited into cutaneous antigen challenge sites J. Leukoc. Biol., November 1, 2004; 76(5): 941 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. VALBUENA and D. H. WALKER EFFECT OF BLOCKING THE CXCL9/10-CXCR3 CHEMOKINE SYSTEM IN THE OUTCOME OF ENDOTHELIAL-TARGET RICKETTSIAL INFECTIONS Am J Trop Med Hyg, October 1, 2004; 71(4): 393 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Hildebrandt, L. A. Corrion, K. M. Olkiewicz, B. Lu, K. Lowler, U. A. Duffner, B. B. Moore, W. A. Kuziel, C. Liu, and K. R. Cooke Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome J. Immunol., August 1, 2004; 173(3): 2050 - 2059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Colvin, G. S. V. Campanella, J. Sun, and A. D. Luster Intracellular Domains of CXCR3 That Mediate CXCL9, CXCL10, and CXCL11 Function J. Biol. Chem., July 16, 2004; 279(29): 30219 - 30227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. El-Sawy, M. Miura, and R. Fairchild Early T Cell Response to Allografts Occuring Prior to Alloantigen Priming Up-Regulates Innate-Mediated Inflammation and Graft Necrosis Am. J. Pathol., July 1, 2004; 165(1): 147 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Whiting, G. Hsieh, J. J. Yun, A. Banerji, W. Yao, M. C. Fishbein, J. Belperio, R. M. Strieter, B. Bonavida, and A. Ardehali Chemokine Monokine Induced by IFN-{gamma}/CXC Chemokine Ligand 9 Stimulates T Lymphocyte Proliferation and Effector Cytokine Production J. Immunol., June 15, 2004; 172(12): 7417 - 7424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kondo, K. Ohmori, A. Oshita, H. Takeuchi, J. Yoshida, K. Shinomiya, S. Fuke, T. Suzuki, K. Mizushige, and M. Kohno Leukocyte-Targeted Myocardial Contrast Echocardiography Can Assess the Degree of Acute Allograft Rejection in a Rat Cardiac Transplantation Model Circulation, March 2, 2004; 109(8): 1056 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Colvin, A. E. Morelli, A. J. Logar, A. H. Lau, and A. W. Thomson Comparative evaluation of CC chemokine-induced migration of murine CD8{alpha}+ and CD8{alpha}- dendritic cells and their in vivo trafficking J. Leukoc. Biol., February 1, 2004; 75(2): 275 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Abdi, T. K. Means, T. Ito, R. N. Smith, N. Najafian, M. Jurewicz, V. Tchipachvili, I. Charo, H. Auchincloss Jr., M. H. Sayegh, et al. Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo J. Immunol., January 15, 2004; 172(2): 767 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Richards, S. L. Dalheimer, M. I. Hertz, and D. L. Mueller Trachea Allograft Class I Molecules Directly Activate and Retain CD8+ T Cells That Cause Obliterative Airways Disease J. Immunol., December 15, 2003; 171(12): 6919 - 6928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Belperio, M. P. Keane, M. D. Burdick, J. P. Lynch III, D. A. Zisman, Y. Y. Xue, K. Li, A. Ardehali, D. J. Ross, and R. M. Strieter Role of CXCL9/CXCR3 Chemokine Biology during Pathogenesis of Acute Lung Allograft Rejection J. Immunol., November 1, 2003; 171(9): 4844 - 4852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Valbuena, W. Bradford, and D. H. Walker Expression Analysis of the T-Cell-Targeting Chemokines CXCL9 and CXCL10 in Mice and Humans with Endothelial Infections Caused by Rickettsiae of the Spotted Fever Group Am. J. Pathol., October 1, 2003; 163(4): 1357 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ichiba, T. Teshima, R. Kuick, D. E. Misek, C. Liu, Y. Takada, Y. Maeda, P. Reddy, D. L. Williams, S. M. Hanash, et al. Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays Blood, July 15, 2003; 102(2): 763 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-W. Zhang, D. D. Kish, and R. L. Fairchild Absence of Allograft ICAM-1 Attenuates Alloantigen-Specific T Cell Priming, But Not Primed T Cell Trafficking into the Graft, to Mediate Acute Rejection J. Immunol., June 1, 2003; 170(11): 5530 - 5537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miura, T. El-Sawy, and R. L. Fairchild Neutrophils Mediate Parenchymal Tissue Necrosis and Accelerate the Rejection of Complete Major Histocompatibility Complex-Disparate Cardiac Allografts in the Absence of Interferon-{gamma} Am. J. Pathol., February 1, 2003; 162(2): 509 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jiankuo, W. Xingbing, H. Baojun, W. Xiongwin, L. Zhuoya, X. Ping, X. Yong, L. Anting, H. Chunsong, G. Feili, et al. Peptide Nucleic Acid Antisense Prolongs Skin Allograft Survival by Means of Blockade of CXCR3 Expression Directing T Cells into Graft J. Immunol., February 1, 2003; 170(3): 1556 - 1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Bek, H. C. Reinhardt, K.-G. Fischer, J. R. Hirsch, C. Hupfer, E. Dayal, and H. Pavenstadt Up-Regulation of Early Growth Response Gene-1 Via the CXCR3 Receptor Induces Reactive Oxygen Species and Inhibits Na+/K+-ATPase Activity in an Immortalized Human Proximal Tubule Cell Line J. Immunol., January 15, 2003; 170(2): 931 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Feng, D. Wang, R. Yuan, C. M. Parker, D. L. Farber, and G. A. Hadley CD103 Expression Is Required for Destruction of Pancreatic Islet Allografts by CD8+ T Cells J. Exp. Med., October 7, 2002; 196(7): 877 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Yun, M. P. Fischbein, D. Whiting, Y. Irie, M. C. Fishbein, M. D. Burdick, J. Belperio, R. M. Strieter, H. Laks, J. A. Berliner, et al. The Role of MIG/CXCL9 in Cardiac Allograft Vasculopathy Am. J. Pathol., October 1, 2002; 161(4): 1307 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Abdi, R. N. Smith, L. Makhlouf, N. Najafian, A. D. Luster, H. Auchincloss Jr., and M. H. Sayegh The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection Diabetes, August 1, 2002; 51(8): 2489 - 2495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Park, D. Amichay, P. Love, E. Wick, F. Liao, A. Grinberg, R. L. Rabin, H. H. Zhang, S. Gebeyehu, T. M. Wright, et al. The CXC Chemokine Murine Monokine Induced by IFN-{gamma} (CXC Chemokine Ligand 9) Is Made by APCs, Targets Lymphocytes Including Activated B Cells, and Supports Antibody Responses to a Bacterial Pathogen In Vivo J. Immunol., August 1, 2002; 169(3): 1433 - 1443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. X.-M. Zhao, Y. Hu, G. G. Miller, A. D. Luster, R. N. Mitchell, and P. Libby Differential Expression of the IFN-{gamma}-Inducible CXCR3-Binding Chemokines, IFN-Inducible Protein 10, Monokine Induced by IFN, and IFN-Inducible T Cell {alpha} Chemoattractant in Human Cardiac Allografts: Association with Cardiac Allograft Vasculopathy and Acute Rejection J. Immunol., August 1, 2002; 169(3): 1556 - 1560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Belperio, M. P. Keane, M. D. Burdick, J. P. Lynch III, Y. Y. Xue, K. Li, D. J. Ross, and R. M. Strieter Critical Role for CXCR3 Chemokine Biology in the Pathogenesis of Bronchiolitis Obliterans Syndrome J. Immunol., July 15, 2002; 169(2): 1037 - 1049. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
