| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107; and
Department of Molecular Neuroimmunology, Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany
We have recently demonstrated that increased blood-CNS barrier permeability and CNS inflammation in a conventional mouse model of experimental allergic encephalomyelitis are dependent upon the production of peroxynitrite (ONOO-), a product of the free radicals NO· and superoxide (O2·-). To determine whether this is a reflection of the physiological contribution of ONOO- to an immune response against a neurotropic pathogen, we have assessed the effects on adult rats acutely infected with Borna disease virus (BDV) of administration of uric acid (UA), an inhibitor of select chemical reactions associated with ONOO-. The pathogenesis of acute Borna disease in immunocompetent adult rats results from the immune response to the neurotropic BDV, rather than the direct effects of BDV infection of neurons. An important stage in the BDV-specific neuroimmune response is the invasion of inflammatory cells into the CNS. UA treatment inhibited the onset of clinical disease, and prevented the elevated blood-brain barrier permeability as well as CNS inflammation seen in control-treated BDV-infected rats. The replication and spread of BDV in the CNS were unchanged by the administration of UA, and only minimal effects on the immune response to BDV Ags were observed. These results indicate that the CNS inflammatory response to neurotropic virus infection is likely to be dependent upon the activity of ONOO- or its products on the blood-brain barrier.
This article has been cited by other articles:
|
|
 |
|
  M. J. Fabis, T. W. Phares, R. B. Kean, H. Koprowski, and D. C. Hooper Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity PNAS, October 7, 2008; 105(40): 15511 - 15516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Haussinger and F Schliess Pathogenetic mechanisms of hepatic encephalopathy Gut, August 1, 2008; 57(8): 1156 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weisskopf, E O'Reilly, H Chen, M. Schwarzschild, and A Ascherio Plasma Urate and Risk of Parkinson's Disease Am. J. Epidemiol., September 1, 2007; 166(5): 561 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Roy and D. C. Hooper Lethal Silver-Haired Bat Rabies Virus Infection Can Be Prevented by Opening the Blood-Brain Barrier J. Virol., August 1, 2007; 81(15): 7993 - 7998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Phares, M. J. Fabis, C. M. Brimer, R. B. Kean, and D. C. Hooper A Peroxynitrite-Dependent Pathway Is Responsible for Blood-Brain Barrier Permeability Changes during a Central Nervous System Inflammatory Response: TNF-{alpha} Is Neither Necessary nor Sufficient J. Immunol., June 1, 2007; 178(11): 7334 - 7343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Phares, R. B. Kean, T. Mikheeva, and D. C. Hooper Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system. J. Immunol., June 15, 2006; 176(12): 7666 - 7675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Pogrebnyak, M. Golovkin, V. Andrianov, S. Spitsin, Y. Smirnov, R. Egolf, and H. Koprowski Severe acute respiratory syndrome (SARS) S protein production in plants: Development of recombinant vaccine PNAS, June 21, 2005; 102(25): 9062 - 9067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Scott, S. Cuzzocrea, T. Genovese, H. Koprowski, and D. C. Hooper Uric acid protects against secondary damage after spinal cord injury PNAS, March 1, 2005; 102(9): 3483 - 3488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Scott, R. B. Kean, T. Mikheeva, M. J. Fabis, J. G. Mabley, C. Szabo, and D. C. Hooper The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation J. Pharmacol. Exp. Ther., September 1, 2004; 310(3): 1053 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Prosniak, A. Zborek, G. S. Scott, A. Roy, T. W. Phares, H. Koprowski, and D. C. Hooper Differential expression of growth factors at the cellular level in virus-infected brain PNAS, May 27, 2003; 100(11): 6765 - 6770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bronte, P. Serafini, C. De Santo, I. Marigo, V. Tosello, A. Mazzoni, D. M. Segal, C. Staib, M. Lowel, G. Sutter, et al. IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice J. Immunol., January 1, 2003; 170(1): 270 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Scott, S. V. Spitsin, R. B. Kean, T. Mikheeva, H. Koprowski, and D. C. Hooper Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors PNAS, December 10, 2002; 99(25): 16303 - 16308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. PALL NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity FASEB J, September 1, 2002; 16(11): 1407 - 1417. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
