| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Production by T Cells in Experimental Chagas’ Disease Is Mediated by IL-181
*
Max Planck Institute for Immunobiology and
Department of Pathology, Freiburg, Germany;
Department of Special Zoology and Parasitology, Ruhr-University, Bochum, Germany;
Institute of Immunology, University of Leipzig, Leipzig, Germany;
¶ Department of Immunology, Institut Pasteur, Paris, France; and
||
Department of Immunology, University of Cape Town, Cape Town, South Africa
IL-12p35-deficient (IL-12p35-/-) mice were highly
susceptible to Trypanosoma cruzi infection and succumbed
during acute infection, demonstrating the crucial importance of
endogenous IL-12 in resistance to experimental Chagas’ disease.
Delayed immune responses were observed in mutant mice, although
comparable IFN-
and TNF-
blood levels as in wild-type mice were
detected 2 wk postinfection. In vivo and in vitro analysis demonstrated
that T cells, but not NK cells, were recruited to infected organs.
Analysis of mice double deficient in the recombinase-activating gene 2
(RAG2) and IL-12p35, as well as studies involving T cell
depletion, identified CD4+ T cells as the cellular source
for IL-12-independent IFN- production. IL-18 was induced in
IL-12p35-/- mice and was responsible for IFN-
production, as demonstrated by in vivo IL-18 neutralization studies. In
conclusion, evidence is presented for an IL-12-independent IFN-
production in experimental Chagas’ disease that is T cell and IL-18
dependent.
This article has been cited by other articles:
|
|
 |
|
  L. M. Johnson and P. Scott STAT1 Expression in Dendritic Cells, but Not T Cells, Is Required for Immunity to Leishmania major J. Immunol., June 1, 2007; 178(11): 7259 - 7266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Way, C. Havenar-Daughton, G. A. Kolumam, N. N. Orgun, and K. Murali-Krishna IL-12 and Type-I IFN Synergize for IFN-{gamma} Production by CD4 T Cells, Whereas Neither Are Required for IFN-{gamma} Production by CD8 T Cells after Listeria monocytogenes Infection J. Immunol., April 1, 2007; 178(7): 4498 - 4505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Murray, C. W. Tsai, J. Liu, and X. Ma Responses to Leishmania donovani in Mice Deficient in Interleukin-12 (IL-12), IL-12/IL-23, or IL-18 Infect. Immun., July 1, 2006; 74(7): 4370 - 4374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Reyes, L. I. Terrazas, B. Espinoza, D. Cruz-Robles, V. Soto, I. Rivera-Montoya, L. Gomez-Garcia, H. Snider, A. R. Satoskar, and M. Rodriguez-Sosa Macrophage Migration Inhibitory Factor Contributes to Host Defense against Acute Trypanosoma cruzi Infection. Infect. Immun., June 1, 2006; 74(6): 3170 - 3179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Sardinha, R. M. Elias, T. Mosca, K. R. B. Bastos, C. R. F. Marinho, M. R. D'Imperio Lima, and J. M. Alvarez Contribution of NK, NK T, {gamma}{delta} T, and {alpha}{beta} T Cells to the Gamma Interferon Response Required for Liver Protection against Trypanosoma cruzi Infect. Immun., April 1, 2006; 74(4): 2031 - 2042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Drennan, B. Stijlemans, J. Van Den Abbeele, V. J. Quesniaux, M. Barkhuizen, F. Brombacher, P. De Baetselier, B. Ryffel, and S. Magez The Induction of a Type 1 Immune Response following a Trypanosoma brucei Infection Is MyD88 Dependent J. Immunol., August 15, 2005; 175(4): 2501 - 2509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Schuetze, S. Schoeneberger, U. Mueller, M. A. Freudenberg, G. Alber, and R. K. Straubinger IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages Int. Immunol., May 1, 2005; 17(5): 649 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Holscher, A. Holscher, D. Ruckerl, T. Yoshimoto, H. Yoshida, T. Mak, C. Saris, and S. Ehlers The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis J. Immunol., March 15, 2005; 174(6): 3534 - 3544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodriguez-Sosa, R. Saavedra, E. P. Tenorio, L. E. Rosas, A. R. Satoskar, and L. I. Terrazas A STAT4-Dependent Th1 Response Is Required for Resistance to the Helminth Parasite Taenia crassiceps Infect. Immun., August 1, 2004; 72(8): 4552 - 4560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Martins, C. E. Tadokoro, R. B. Silva, J. S. Silva, and L. V. Rizzo CTLA-4 Blockage Increases Resistance to Infection with the Intracellular Protozoan Trypanosoma cruzi J. Immunol., April 15, 2004; 172(8): 4893 - 4901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Campos, M. Closel, E. P. Valente, J. E. Cardoso, S. Akira, J. I. Alvarez-Leite, C. Ropert, and R. T. Gazzinelli Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection with Trypanosoma cruzi in Mice Lacking Functional Myeloid Differentiation Factor 88 J. Immunol., February 1, 2004; 172(3): 1711 - 1718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fieschi, S. Dupuis, E. Catherinot, J. Feinberg, J. Bustamante, A. Breiman, F. Altare, R. Baretto, F. Le Deist, S. Kayal, et al. Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor {beta}1 Deficiency: Medical and Immunological Implications J. Exp. Med., February 17, 2003; 197(4): 527 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Huang, S. A. McClellan, R. P. Barrett, and L. D. Hazlett IL-18 Contributes to Host Resistance Against Infection with Pseudomonas aeruginosa Through Induction of IFN-{gamma} Production J. Immunol., June 1, 2002; 168(11): 5756 - 5763. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
