| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
B Signaling Reveals a Novel Role for NF-B in the Regulation of TNF-Related Apoptosis-Inducing Ligand Expression1
,
,,,
*
Terry Fox Molecular Oncology Group,
Lady Davis Institute for Medical Research, and Departments of
Microbiology and Immunology and
Medicine and Oncology, McGill University, Montreal, Canada
The NF-
B family of transcription factors functions broadly in
the host control of immunoregulatory gene expression, inflammation, and
apoptosis. Using Jurkat T cells engineered to inducibly express a
transdominant repressor of IB
, we examined the role of NF-B in
the regulation of cytokine and apoptotic gene expression. In this T
cell model, as well as in primary T lymphocytes, expression of
TNF-related apoptosis-inducing ligand (TRAIL) apoptotic signaling
protein was dramatically down-regulated by inhibition of NF-B
binding activity. TRAIL acts through membrane death receptors to induce
apoptosis of activated T lymphocytes and can be up-regulated by a
variety of physiological and pharmacological inducers. However,
regulation of TRAIL gene expression has not been defined. Treatment
with TCR mimetics (PMA/ionomycin, PHA, and anti-CD3/CD28 Abs)
resulted in a rapid increase in the expression of TRAIL mRNA and cell
surface TRAIL protein. Induction of the transdominant repressor of
IB dramatically down-regulated surface expression of TRAIL,
indicating an essential role for NF-B in the regulation of TRAIL.
The induced expression of TRAIL was linked to a c-Rel binding
site in the proximal TRAIL promoter at position -256 to -265;
mutation of this site or an adjacent B site resulted in a complete
loss of the inducibility of the TRAIL promoter. The regulation of TRAIL
expression by NF-B may represent a general mechanism that
contributes to the control of TRAIL-mediated apoptosis in T
lymphocytes.
This article has been cited by other articles:
|
|
 |
|
  L. Ban, J. Zhang, L. Wang, W. Kuhtreiber, D. Burger, and D. L. Faustman Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism PNAS, September 9, 2008; 105(36): 13644 - 13649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, J.-Y. Zhou, W.-Z. Wei, S. Philipsen, and G. S. Wu Sp1-Mediated TRAIL Induction in Chemosensitization Cancer Res., August 15, 2008; 68(16): 6718 - 6726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fionda, F. Nappi, M. Piccoli, L. Frati, A. Santoni, and M. Cippitelli Inhibition of Trail Gene Expression by Cyclopentenonic Prostaglandin 15-Deoxy-{Delta}12,14-Prostaglandin J2 in T Lymphocytes Mol. Pharmacol., November 1, 2007; 72(5): 1246 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lin, W. Wei, J. Zhang, S. Liu, Y. Liu, and D. Zheng Formyl peptide receptor-like 1 mediated endogenous TRAIL gene expression with tumoricidal activity Mol. Cancer Ther., October 1, 2007; 6(10): 2618 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. N. Ivanov, H. Zhou, and T. K. Hei Sequential Treatment by Ionizing Radiation and Sodium Arsenite Dramatically Accelerates TRAIL-Mediated Apoptosis of Human Melanoma Cells Cancer Res., June 1, 2007; 67(11): 5397 - 5407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y. Kimura, C. Iwamura, A. Suzuki, T. Miki, A. Hasegawa, K. Sugaya, M. Yamashita, S. Ishii, and T. Nakayama Schnurri-2 Controls Memory Th1 and Th2 Cell Numbers In Vivo J. Immunol., April 15, 2007; 178(8): 4926 - 4936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Taylor and W. A. Bresnahan Human Cytomegalovirus IE86 Attenuates Virus- and Tumor Necrosis Factor Alpha-Induced NF{kappa}B-Dependent Gene Expression. J. Virol., November 1, 2006; 80(21): 10763 - 10771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, J.-Y. Zhou, and G. S. Wu Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Is Required for Tumor Necrosis Factor {alpha}-Mediated Sensitization of Human Breast Cancer Cells to Chemotherapy. Cancer Res., October 15, 2006; 66(20): 10092 - 10099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. O. Baxter, P. J. Came, K. Abell, B. Kedjouar, M. Huth, K. Rajewsky, M. Pasparakis, and C. J. Watson IKK{beta}/2 induces TWEAK and apoptosis in mammary epithelial cells Development, September 1, 2006; 133(17): 3485 - 3494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang, E. Bi, Y. Hu, W. Deng, Z. Tian, C. Dong, Y. Hu, and B. Sun A Novel NF-{kappa}B Binding Site Controls Human Granzyme B Gene Transcription J. Immunol., April 1, 2006; 176(7): 4173 - 4181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kirshner, A. Y. Karpova, M. Kops, and P. M. Howley Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target J. Virol., July 15, 2005; 79(14): 9320 - 9324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Matsuda, A. Almasan, M. Tomita, K. Tamaki, M. Saito, M. Tadano, H. Yagita, T. Ohta, and N. Mori Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand J. Gen. Virol., April 1, 2005; 86(4): 1055 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsuda, A. Almasan, M. Tomita, J.-n. Uchihara, M. Masuda, K. Ohshiro, N. Takasu, H. Yagita, T. Ohta, and N. Mori Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines J. Virol., February 1, 2005; 79(3): 1367 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Wurzer, C. Ehrhardt, S. Pleschka, F. Berberich-Siebelt, T. Wolff, H. Walczak, O. Planz, and S. Ludwig NF-{kappa}B-dependent Induction of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas/FasL Is Crucial for Efficient Influenza Virus Propagation J. Biol. Chem., July 23, 2004; 279(30): 30931 - 30937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. N. Ivanov and T. K. Hei Arsenite Sensitizes Human Melanomas to Apoptosis via Tumor Necrosis Factor {alpha}-mediated Pathway J. Biol. Chem., May 21, 2004; 279(21): 22747 - 22758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Droin, M. J. Pinkoski, E. Dejardin, and D. R. Green Egr Family Members Regulate Nonlymphoid Expression of Fas Ligand, TRAIL, and Tumor Necrosis Factor during Immune Responses Mol. Cell. Biol., November 1, 2003; 23(21): 7638 - 7647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chawla-Sarkar, J. A. Bauer, J. A. Lupica, B. H. Morrison, Z. Tang, R. K. Oates, A. Almasan, J. A. DiDonato, E. C. Borden, and D. J. Lindner Suppression of NF-{kappa}B Survival Signaling by Nitrosylcobalamin Sensitizes Neoplasms to the Anti-tumor Effects of Apo2L/TRAIL J. Biol. Chem., October 10, 2003; 278(41): 39461 - 39469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mahr, J. M. Boss, and L. R. Gooding The Adenovirus E3 Promoter Is Sensitive to Activation Signals in Human T Cells J. Virol., December 20, 2002; 77(2): 1112 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Baumann, F. Bohnenstengel, D. Siegmund, H. Wajant, C. Weber, I. Herr, K.-M. Debatin, P. Proksch, and T. Wirth Rocaglamide Derivatives Are Potent Inhibitors of NF-kappa B Activation in T-cells J. Biol. Chem., November 15, 2002; 277(47): 44791 - 44800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ren, A. Schmalstieg, N. S. C. van Oers, and R. B. Gaynor I-{kappa}B Kinases {alpha} and {beta} Have Distinct Roles in Regulating Murine T Cell Function J. Immunol., April 15, 2002; 168(8): 3721 - 3731. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
