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*Substance via MeSH
Medline Plus Health Information
*Autoimmune Diseases
The Journal of Immunology, 2001, 167: 3074-3081.
Copyright © 2001 by The American Association of Immunologists

The Role of IFN-{gamma} in the Production of Th2 Subpopulations: Implications for Variable Th2-Mediated Pathologies in Autoimmunity1

Allen Wensky{dagger},{ddagger}, Maria Cecília Garibaldi Marcondes{dagger} and Juan J. Lafaille2,{dagger}

* Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and {dagger} Department of Pathology and {ddagger} Sackler Institute of Graduate Biomedical Sciences, New York University Medical Center, New York, NY 10016

It has become increasingly apparent in studies of mutant mice and observations of disease that cytokine production by fully committed effector T cells within the Th1 and Th2 phenotype can vary within each group. This can potentially influence the type and effectiveness of a given immune response. The factors responsible for inducing variable Th1 and Th2 subtype responses have not been well established. Using transgenic mice expressing the myelin basic protein-specific TCR, we demonstrate here that two distinct populations of Th2 cells that are characterized primarily by differential IL-4 and IL-5 expression levels can be generated depending upon the levels of IFN-{gamma} present at the time of priming. We also demonstrate that populations expressing high levels of IL-4 relative to IL-5 vs those with intermediate levels of IL-4 relative to IL-5 are stable and possess distinct effector functions in an experimental autoimmune encephalomyelitis model.




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