| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, and
Core Research for Evolutional Science and Technology Program of the Japan Science and Technology Corporation, Sendai, Japan
OX40 ligand (OX40L) expressed on APCs, and its receptor, OX40
present on activated T cells, are members of the TNF/TNFR family,
respectively, and have been located at the sites of inflammatory
conditions. We have observed in OX40L-deficient mice
(OX40L-/-) an impaired APC capacity and in our recently
constructed transgenic mice expressing OX40L (OX40L-Tg), a markedly
enhanced T cell response to protein Ags. Using these mice, we
demonstrate here the critical involvement of the OX40L-OX40 interaction
during the T cell priming events in the occurrence of experimental
autoimmune encephalomyelitis (EAE). In OX40L-/- mice,
abortive T cell priming greatly reduced the clinical manifestations of
actively induced EAE, coupled with a reduction in IFN-
, IL-2, and
IL-6 production in vitro. Adoptive transfer experiments however
revealed an efficient transfer of disease to OX40L-/-
mice using wild-type donor T cells, indicating an intact capacity of
OX40L-/- mice to initiate effector responses. On the
other hand, OX40L-/- donor T cells failed to transfer
disease to wild-type recipient mice. Furthermore, OX40L-Tg mice
developed a greater severity of EAE despite a delayed onset, while both
OX40L-Tg/CD28-/- and OX40L-Tg/CD40-/- mice
failed to develop EAE demonstrating a requisite for these molecules.
These findings indicate a pivotal role played by OX40L in the
pathogenesis of EAE.
This article has been cited by other articles:
|
|
 |
|
  I. Gotsman, A. H. Sharpe, and A. H. Lichtman T-Cell Costimulation and Coinhibition in Atherosclerosis Circ. Res., November 21, 2008; 103(11): 1220 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Torii, T. Ito, R. Amakawa, H. Sugimoto, H. Amuro, T. Tanijiri, Y. Katashiba, M. Ogata, T. Yokoi, and S. Fukuhara Imidazoquinoline Acts as Immune Adjuvant for Functional Alteration of Thymic Stromal Lymphopoietin-Mediated Allergic T Cell Response J. Immunol., October 15, 2008; 181(8): 5340 - 5349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Vu, X. Xiao, W. Gao, N. Degauque, M. Chen, A. Kroemer, N. Killeen, N. Ishii, and X. Chang Li OX40 costimulation turns off Foxp3+ Tregs Blood, October 1, 2007; 110(7): 2501 - 2510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tomizawa, Y. Kaneko, Y. Kaneko, Y. Saito, H. Ohnishi, J. Okajo, C. Okuzawa, T. Ishikawa-Sekigami, Y. Murata, H. Okazawa, et al. Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice J. Immunol., July 15, 2007; 179(2): 869 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-K. L. Robertson and G. K Hansson T Cells in Atherogenesis: For Better or For Worse? Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2421 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Tran, Y.-T. Azuma, M. Chen, C. Weston, R. J. Davis, and R. A. Flavell Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain PNAS, September 5, 2006; 103(36): 13451 - 13456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ito, Y.-H. Wang, O. Duramad, S. Hanabuchi, O. A. Perng, M. Gilliet, F. X.-F. Qin, and Y.-J. Liu OX40 ligand shuts down IL-10-producing regulatory T cells PNAS, August 29, 2006; 103(35): 13138 - 13143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Soroosh, S. Ine, K. Sugamura, and N. Ishii OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity J. Immunol., May 15, 2006; 176(10): 5975 - 5987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Vu, M. R. Clarkson, H. Yagita, L. A. Turka, M. H. Sayegh, and X. C. Li Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection J. Immunol., February 1, 2006; 176(3): 1394 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Ponomarev, L. P. Shriver, and B. N. Dittel CD40 Expression by Microglial Cells Is Required for Their Completion of a Two-Step Activation Process during Central Nervous System Autoimmune Inflammation J. Immunol., February 1, 2006; 176(3): 1402 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Salek-Ardakani, T. So, B. S. Halteman, A. Altman, and M. Croft Protein Kinase C{theta} Controls Th1 Cells in Experimental Autoimmune Encephalomyelitis J. Immunol., December 1, 2005; 175(11): 7635 - 7641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ito, Y.-H. Wang, O. Duramad, T. Hori, G. J. Delespesse, N. Watanabe, F. X.-F. Qin, Z. Yao, W. Cao, and Y.-J. Liu TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand J. Exp. Med., November 7, 2005; 202(9): 1213 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Y. Ma, S. A. Mikolajczak, A. Danesh, K. A. Hosiawa, C. M. Cameron, A. Takaori-Kondo, T. Uchiyama, D. J. Kelvin, and A. Ochi The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells Blood, September 15, 2005; 106(6): 2002 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Schmidt, J. Zhao, J. Chain, D. Hepburn, B. Gitter, G. Sandusky, S. Chintalacharuvu, A. Glasebrook, and S. Na Resistance to Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis by Death Receptor 6-Deficient Mice J. Immunol., August 15, 2005; 175(4): 2286 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Valzasina, C. Guiducci, H. Dislich, N. Killeen, A. D. Weinberg, and M. P. Colombo Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR Blood, April 1, 2005; 105(7): 2845 - 2851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Andarini, T. Kikuchi, M. Nukiwa, P. Pradono, T. Suzuki, S. Ohkouchi, A. Inoue, M. Maemondo, N. Ishii, Y. Saijo, et al. Adenovirus Vector-Mediated in Vivo Gene Transfer of OX40 Ligand to Tumor Cells Enhances Antitumor Immunity of Tumor-Bearing Hosts Cancer Res., May 1, 2004; 64(9): 3281 - 3287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Takeda, S. Ine, N. Killeen, L. C. Ndhlovu, K. Murata, S. Satomi, K. Sugamura, and N. Ishii Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells J. Immunol., March 15, 2004; 172(6): 3580 - 3589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Demirci, F. Amanullah, R. Kewalaramani, H. Yagita, T. B. Strom, M. H. Sayegh, and X. C. Li Critical Role of OX40 in CD28 and CD154-Independent Rejection J. Immunol., February 1, 2004; 172(3): 1691 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Martin-Orozco, Z. Chen, L. Poirot, E. Hyatt, A. Chen, O. Kanagawa, A. Sharpe, D. Mathis, and C. Benoist Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand J. Immunol., December 15, 2003; 171(12): 6954 - 6960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Blazar, A. H. Sharpe, A. I. Chen, A. Panoskaltsis-Mortari, C. Lees, H. Akiba, H. Yagita, N. Killeen, and P. A. Taylor Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients Blood, May 1, 2003; 101(9): 3741 - 3748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gri, E. Gallo, E. Di Carlo, P. Musiani, and M. P. Colombo OX40 Ligand-Transduced Tumor Cell Vaccine Synergizes with GM-CSF and Requires CD40-Apc Signaling to Boost the Host T Cell Antitumor Response J. Immunol., January 1, 2003; 170(1): 99 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Murata, M. Nose, L. C. Ndhlovu, T. Sato, K. Sugamura, and N. Ishii Constitutive OX40/OX40 Ligand Interaction Induces Autoimmune-Like Diseases J. Immunol., October 15, 2002; 169(8): 4628 - 4636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yamada, A. D. Salama, and M. H. Sayegh The Role of Novel T Cell Costimulatory Pathways in Autoimmunity and Transplantation J. Am. Soc. Nephrol., February 1, 2002; 13(2): 559 - 575. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
