| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois-Lausanne, Lausanne, Switzerland;
Pharma Research, Novartis, Basel, Switzerland; and
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
LPS-binding protein (LBP) and CD14 potentiate cell
activation by LPS, contributing to lethal endotoxemia. We analyzed the
contribution of LBP/CD14 in models of bacterial infection. Mice
pretreated with mAbs neutralizing CD14 or LBP showed a delay in TNF-
production and died of overwhelming infection within 24 h, after a
challenge with 250 CFU of virulent Klebsiella
pneumoniae. Blockade of TNF- also increased lethality,
whereas pretreatment with TNF- protected mice, even in the presence
of LBP and CD14 blockade. Anti-LBP or anti-CD14 mAbs did not
improve or decrease lethality with a higher inoculum (105
K. pneumoniae) and did not affect outcome following
injections of low or high inocula of Escherichia coli
O111. These results point to the essential role of LBP/CD14 in innate
immunity against virulent bacteria.
This article has been cited by other articles:
|
|
 |
|
  T. Roger, C. Froidevaux, D. Le Roy, M. K. Reymond, A.-L. Chanson, D. Mauri, K. Burns, B. M. Riederer, S. Akira, and T. Calandra Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4 PNAS, February 17, 2009; 106(7): 2348 - 2352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Chien, M. J. Boeckh, J. A. Hansen, and J. G. Clark Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation Blood, February 15, 2008; 111(4): 2462 - 2469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Dessing, S. Knapp, S. Florquin, A. F. de Vos, and T. van der Poll CD14 Facilitates Invasive Respiratory Tract Infection by Streptococcus pneumoniae Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 604 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Knapp, U. Matt, N. Leitinger, and T. van der Poll Oxidized Phospholipids Inhibit Phagocytosis and Impair Outcome in Gram-Negative Sepsis In Vivo J. Immunol., January 15, 2007; 178(2): 993 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Echchannaoui, K. Frei, M. Letiembre, R. M. Strieter, Y. Adachi, and R. Landmann CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infection J. Leukoc. Biol., September 1, 2005; 78(3): 705 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Munford Invited review: Detoxifying endotoxin: time, place and person Innate Immunity, April 1, 2005; 11(2): 69 - 84. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Hamann, C. Alexander, C. Stamme, U. Zahringer, and R. R. Schumann Acute-Phase Concentrations of Lipopolysaccharide (LPS)-Binding Protein Inhibit Innate Immune Cell Activation by Different LPS Chemotypes via Different Mechanisms Infect. Immun., January 1, 2005; 73(1): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Branger, S. Florquin, S. Knapp, J. C. Leemans, J. M. Pater, P. Speelman, D. T. Golenbock, and T. van der Poll LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia Int. Immunol., November 1, 2004; 16(11): 1605 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Bannerman, M. J. Paape, W. R. Hare, and J. C. Hope Characterization of the Bovine Innate Immune Response to Intramammary Infection with Klebsiella pneumoniae J Dairy Sci, August 1, 2004; 87(8): 2420 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cetin, H. R. Ford, L. R. Sysko, C. Agarwal, J. Wang, M. D. Neal, C. Baty, G. Apodaca, and D. J. Hackam Endotoxin Inhibits Intestinal Epithelial Restitution through Activation of Rho-GTPase and Increased Focal Adhesions J. Biol. Chem., June 4, 2004; 279(23): 24592 - 24600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Bannerman, M. J. Paape, J.-W. Lee, X. Zhao, J. C. Hope, and P. Rainard Escherichia coli and Staphylococcus aureus Elicit Differential Innate Immune Responses following Intramammary Infection Clin. Vaccine Immunol., May 1, 2004; 11(3): 463 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Heumann, R. Lauener, and B. Ryffel The dual role of LBP and CD14 in response to Gram-negative bacteria or Gram-negative compounds Innate Immunity, December 1, 2003; 9(6): 381 - 384. [Abstract] [PDF]
|
|
|
|
|
|
S. Knapp, A. F. de Vos, S. Florquin, D. T. Golenbock, and T. van der Poll Lipopolysaccharide Binding Protein Is an Essential Component of the Innate Immune Response to Escherichia coli Peritonitis in Mice Infect. Immun., December 1, 2003; 71(12): 6747 - 6753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Bannerman, M. J. Paape, W. R. Hare, and E. J. Sohn Increased Levels of LPS-Binding Protein in Bovine Blood and Milk Following Bacterial Lipopolysaccharide Challenge J Dairy Sci, October 1, 2003; 86(10): 3128 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ying, H. Suzuki, H. Furumoto, R. Walker, P. Meltzer, M. C. Willingham, and S.-Y. Cheng Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma Carcinogenesis, September 1, 2003; 24(9): 1467 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tasaka, A. Ishizaka, W. Yamada, M. Shimizu, H. Koh, N. Hasegawa, Y. Adachi, and K. Yamaguchi Effect of CD14 Blockade on Endotoxin-Induced Acute Lung Injury in Mice Am. J. Respir. Cell Mol. Biol., August 1, 2003; 29(2): 252 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A J Kvalsvig and D J Unsworth The immunopathogenesis of meningococcal disease J. Clin. Pathol., June 1, 2003; 56(6): 417 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Heumann CD14 and LBP in endotoxemia and infections caused by Gram-negative bacteria Innate Immunity, December 1, 2001; 7(6): 439 - 441. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
