HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ostberg, J. R. Articles by Repasky, E. A. Search for Related Content PubMed PubMed Citation Articles by Ostberg, J. R. Articles by Repasky, E. A.

Regulatory Potential of Fever-Range Whole Body Hyperthermia on Langerhans Cells and Lymphocytes in an Antigen-Dependent Cellular Immune Response¹

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263

The febrile response is one of the most common features of infection and inflammation. However, temperature is rarely a variable in experimental immunological investigations. To determine whether the thermal microenvironment has any immunoregulatory potential in an Ag-dependent response, we applied a mild fever-range whole body hyperthermia (FR-WBH) protocol to BALB/c mice experiencing the contact hypersensitivity (CHS) reaction. We observed that the timing of this FR-WBH treatment relative to the different phases of the CHS response was crucial to the outcome. FR-WBH treatment before sensitization with a 0.5% FITC solution resulted in a depressed CHS response. This appears to be due to direct effects of FR-WBH on epidermal Langerhans cell trafficking to the draining lymph nodes. In contrast, application of FR-WBH directly after application of the elicitation dose of FITC solution resulted in an enhanced reaction. This result correlates with increased homing of lymphocytes to the site of elicitation. Overall, these data have important implications regarding the role of thermal changes experienced during infection and the clinical use of FR-WBH relative to immunotherapeutic strategies.

This article has been cited by other articles:

				J. R. Ostberg, B. E. Dayanc, M. Yuan, E. Oflazoglu, and E. A. Repasky Enhancement of natural killer (NK) cell cytotoxicity by fever-range thermal stress is dependent on NKG2D function and is associated with plasma membrane NKG2D clustering and increased expression of MICA on target cells J. Leukoc. Biol., November 1, 2007; 82(5): 1322 - 1331. [Abstract] [Full Text] [PDF]

				S. Basu and P. Srivastava Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells PNAS, April 5, 2005; 102(14): 5120 - 5125. [Abstract] [Full Text] [PDF]

				Y. Makino, H. Nakamura, E. Ikeda, K. Ohnuma, K. Yamauchi, Y. Yabe, L. Poellinger, Y. Okada, C. Morimoto, and H. Tanaka Hypoxia-Inducible Factor Regulates Survival of Antigen Receptor-Driven T Cells J. Immunol., December 15, 2003; 171(12): 6534 - 6540. [Abstract] [Full Text] [PDF]

				S. Basu and P. K. Srivastava Fever-like temperature induces maturation of dendritic cells through induction of hsp90 Int. Immunol., September 1, 2003; 15(9): 1053 - 1061. [Abstract] [Full Text] [PDF]