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The Journal of Immunology, 2001, 167: 2619-2624.
Copyright © 2001 by The American Association of Immunologists

The Recognition of HLA-B27 by Human CD4+ T Lymphocytes1

Louise H. Boyle, Jane C. Goodall, Stephen S. Opat and J. S. Hill Gaston2

University of Cambridge School of Clinical Medicine, Department of Medicine, Cambridge, United Kingdom

HLA-B27 transgenic animal models suggest a role for CD4+ T lymphocytes in the pathogenesis of the spondyloarthropathies, and murine studies have raised the possibility that unusual forms of B27 may be involved in disease. We demonstrate that CD4+ T cells capable of recognizing B27 can be isolated from humans by coculture with the MHC class II-negative cell line T2 transfected with B27. These CD4+ T cells recognize a panel of B27-transfected cell lines that are defective in Ag-processing pathways, but not the nontransfected parental cell lines, in a CD4-dependent fashion. Inhibition of responses by the MHC class I-specific mAb w6/32 and the B27 binding mAb ME1 implicates the recognition of a form of B27 recognized by both of these Abs. We suggest that B27-reactive CD4+ T cells may be pathogenic in spondyloarthropathies, particularly if factors such as infection influence expression of abnormal forms of B27.




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