| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation1
*
McGill Cancer Center, McGill University and Institut de Recherches Cliniques, Montréal, Québec, Canada;
Allergy Research Laboratory, Centre de Recherche du Centre Hospitalier Université de Montréal, Notre-Dame Hospital, Montreal University, Québec, Canada;
Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143;
Immunex Research and Development Corporation, Seattle, WA 98101;
¶ Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110; and
||
Department of Molecular Biology, Max Planck Institute, Martinsried, Germany
Proinflammatory molecules, including IFN-
and IL-12, play a
crucial role in the elimination of causative agents. To allow healing,
potent anti-inflammatory processes are required to down-regulate
the inflammatory response. In this study, we first show that
CD47/integrin-associated protein, a ubiquitous multispan transmembrane
protein highly expressed on T cells, interacts with signal-regulator
protein (SIRP)-
, an immunoreceptor tyrosine-based inhibition
motif-containing molecule selectively expressed on myelomonocytic
cells, and next demonstrate that this pair of molecules negatively
regulates human T and dendritic cell (DC) function. CD47 ligation by
CD47 mAb or L-SIRP- transfectants inhibits IL-12R expression
and down-regulates IL-12 responsiveness of activated CD4+
and CD8+ adult T cells without affecting their response to
IL-2. Human CD47-Fc fusion protein binds SIRP- expressed on immature
DC and mature DC. SIRP- engagement by CD47-Fc prevents the
phenotypic and functional maturation of immature DC and still inhibits
cytokine production by mature DC. Finally, in allogeneic MLR between
mDC and naive T cells, CD47-Fc decreases IFN- production after
priming and impairs the development of a Th1 response. Therefore, CD47
on T cells and its cognate receptor SIRP- on DC define a novel
regulatory pathway that may be involved in the maintenance of
homeostasis by preventing the escalation of the inflammatory immune
response.
This article has been cited by other articles:
|
|
 |
|
  J. Li, J. Park, D. Foss, and I. Goldschneider Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus J. Exp. Med., March 16, 2009; 206(3): 607 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Lawrence, M. S. Denison, H. Novak, B. A. Vorderstrasse, N. Harrer, W. Neruda, C. Reichel, and M. Woisetschlager Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound Blood, August 15, 2008; 112(4): 1158 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-S. Dugast, T. Haudebourg, F. Coulon, M. Heslan, F. Haspot, N. Poirier, R. Vuillefroy de Silly, C. Usal, H. Smit, B. Martinet, et al. Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion J. Immunol., June 15, 2008; 180(12): 7898 - 7906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bouguermouh, V. Q. Van, J. Martel, P. Gautier, M. Rubio, and M. Sarfati CD47 Expression on T Cell Is a Self-Control Negative Regulator of Type 1 Immune Response J. Immunol., June 15, 2008; 180(12): 8073 - 8082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Su, M. Johansen, M. R. Looney, E. J. Brown, and M. A. Matthay CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia J. Immunol., May 15, 2008; 180(10): 6947 - 6953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Tsai and D. E. Discher Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells J. Cell Biol., March 5, 2008; 180(5): 989 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Miyake, Y. Murata, H. Okazawa, H. Ikeda, Y. Niwayama, H. Ohnishi, Y. Hirata, and T. Matozaki Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. Genes Cells, February 1, 2008; 13(2): 209 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bras, V. J. Yuste, G. Roue, S. Barbier, P. Sancho, C. Virely, M. Rubio, S. Baudet, J. E. Esquerda, H. Merle-Beral, et al. Drp1 Mediates Caspase-Independent Type III Cell Death in Normal and Leukemic Cells Mol. Cell. Biol., October 15, 2007; 27(20): 7073 - 7088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tomizawa, Y. Kaneko, Y. Kaneko, Y. Saito, H. Ohnishi, J. Okajo, C. Okuzawa, T. Ishikawa-Sekigami, Y. Murata, H. Okazawa, et al. Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice J. Immunol., July 15, 2007; 179(2): 869 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Okajo, Y. Kaneko, Y. Murata, T. Tomizawa, C. Okuzawa, Y. Saito, Y. Kaneko, T. Ishikawa-Sekigami, H. Okazawa, H. Ohnishi, et al. Regulation by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 of {alpha}-Galactosylceramide-Induced Antimetastatic Activity and Th1 and Th2 Responses of NKT Cells J. Immunol., May 15, 2007; 178(10): 6164 - 6172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ide, H. Wang, H. Tahara, J. Liu, X. Wang, T. Asahara, M. Sykes, Y.-G. Yang, and H. Ohdan Role for CD47-SIRP{alpha} signaling in xenograft rejection by macrophages PNAS, March 20, 2007; 104(12): 5062 - 5066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Braun, L. Galibert, T. Nakajima, H. Saito, V. V. Quang, M. Rubio, and M. Sarfati Semimature Stage: A Checkpoint in a Dendritic Cell Maturation Program That Allows for Functional Reversion after Signal-Regulatory Protein-{alpha} Ligation and Maturation Signals J. Immunol., December 15, 2006; 177(12): 8550 - 8559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Laudanski, C. Miller-Graziano, W. Xiao, M. N. Mindrinos, D. R. Richards, A. De, L. L. Moldawer, R. V. Maier, P. Bankey, H. V. Baker, et al. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways PNAS, October 17, 2006; 103(42): 15564 - 15569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Grimbert, S. Bouguermouh, N. Baba, T. Nakajima, Z. Allakhverdi, D. Braun, H. Saito, M. Rubio, G. Delespesse, and M. Sarfati Thrombospondin/CD47 Interaction: A Pathway to Generate Regulatory T Cells from Human CD4+CD25- T Cells in Response to Inflammation J. Immunol., September 15, 2006; 177(6): 3534 - 3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Lahoud, A. I. Proietto, K. H. Gartlan, S. Kitsoulis, J. Curtis, J. Wettenhall, M. Sofi, C. Daunt, M. O'Keeffe, I. Caminschi, et al. Signal Regulatory Protein Molecules Are Differentially Expressed by CD8- Dendritic Cells J. Immunol., July 1, 2006; 177(1): 372 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hagnerud, P. P. Manna, M. Cella, A. Stenberg, W. A. Frazier, M. Colonna, and P.-A. Oldenborg Deficit of CD47 Results in a Defect of Marginal Zone Dendritic Cells, Blunted Immune Response to Particulate Antigen and Impairment of Skin Dendritic Cell Migration J. Immunol., May 15, 2006; 176(10): 5772 - 5778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Masli, B. Turpie, and J W. Streilein Thrombospondin orchestrates the tolerance-promoting properties of TGF{beta}-treated antigen-presenting cells Int. Immunol., May 1, 2006; 18(5): 689 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Subramanian, R. Parthasarathy, S. Sen, E. T. Boder, and D. E. Discher Species- and cell type-specific interactions between CD47 and human SIRP{alpha} Blood, March 15, 2006; 107(6): 2548 - 2556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ishikawa-Sekigami, Y. Kaneko, H. Okazawa, T. Tomizawa, J. Okajo, Y. Saito, C. Okuzawa, M. Sugawara-Yokoo, U. Nishiyama, H. Ohnishi, et al. SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages Blood, January 1, 2006; 107(1): 341 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. van Beek, F. Cochrane, A. N. Barclay, and T. K. van den Berg Signal Regulatory Proteins in the Immune System J. Immunol., December 15, 2005; 175(12): 7781 - 7787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, I. Soto, Q. Tong, A. Chin, H.-J. Buhring, T. Wu, K. Zen, and C. A. Parkos SIRP{beta}1 Is Expressed as a Disulfide-linked Homodimer in Leukocytes and Positively Regulates Neutrophil Transepithelial Migration J. Biol. Chem., October 28, 2005; 280(43): 36132 - 36140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tenca, A. Merlo, E. Merck, E. E. M. Bates, D. Saverino, R. Simone, D. Zarcone, G. Trinchieri, C. E. Grossi, and E. Ciccone CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells J. Immunol., June 1, 2005; 174(11): 6757 - 6763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-A. Oldenborg CD47 and SIRPs: new openings Blood, March 15, 2005; 105(6): 2245 - 2246. [Full Text] [PDF]
|
|
|
|
|
|
L. Piccio, W. Vermi, K. S. Boles, A. Fuchs, C. A. Strader, F. Facchetti, M. Cella, and M. Colonna Adhesion of human T cells to antigen-presenting cells through SIRP{beta}2-CD47 interaction costimulates T-cell proliferation Blood, March 15, 2005; 105(6): 2421 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Epardaud, M. Bonneau, F. Payot, C. Cordier, J. Megret, C. Howard, and I. Schwartz-Cornil Enrichment for a CD26hi SIRP- subset in lymph dendritic cells from the upper aero-digestive tract J. Leukoc. Biol., September 1, 2004; 76(3): 553 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Brooke, J. D. Holbrook, M. H. Brown, and A. N. Barclay Human Lymphocytes Interact Directly with CD47 through a Novel Member of the Signal Regulatory Protein (SIRP) Family J. Immunol., August 15, 2004; 173(4): 2562 - 2570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. J. Marshall, J. A. Willment, H.-H. Lin, D. L. Williams, S. Gordon, and G. D. Brown Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes J. Biol. Chem., April 9, 2004; 279(15): 14792 - 14802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ogura, T. Noguchi, R. Murai-Takebe, T. Hosooka, N. Honma, and M. Kasuga Resistance of B16 Melanoma Cells to CD47-induced Negative Regulation of Motility as a Result of Aberrant N-Glycosylation of SHPS-1 J. Biol. Chem., April 2, 2004; 279(14): 13711 - 13720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fukunaga, H. Nagai, T. Noguchi, H. Okazawa, T. Matozaki, X. Yu, C. F. Lagenaur, N. Honma, M. Ichihashi, M. Kasuga, et al. Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate 1 Regulates the Migration of Langerhans Cells from the Epidermis to Draining Lymph Nodes J. Immunol., April 1, 2004; 172(7): 4091 - 4099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, M. B. O'Connor, K. J. Mandell, K. Zen, A. Ullrich, H.-J. Buhring, and C. A. Parkos Peptide-Mediated Inhibition of Neutrophil Transmigration by Blocking CD47 Interactions with Signal Regulatory Protein {alpha} J. Immunol., February 15, 2004; 172(4): 2578 - 2585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. T. Chen, E. J. Brown, E. J. Huang, and W. E. Seaman Expression and Activation of Signal Regulatory Protein {alpha} on Astrocytomas Cancer Res., January 1, 2004; 64(1): 117 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tada, M. Tanaka, R. Hanayama, K. Miwa, A. Shinohara, A. Iwamatsu, and S. Nagata Tethering of Apoptotic Cells to Phagocytes through Binding of CD47 to Src Homology 2 Domain-Bearing Protein Tyrosine Phosphatase Substrate-1 J. Immunol., December 1, 2003; 171(11): 5718 - 5726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Smith, V. Patel, S. D. Seatter, M. R. Deehan, M. H. Brown, G. P. Brooke, H. S. Goodridge, C. J. Howard, K. P. Rigley, W. Harnett, et al. A novel MyD-1 (SIRP-1{alpha}) signaling pathway that inhibits LPS-induced TNF{alpha} production by monocytes Blood, October 1, 2003; 102(7): 2532 - 2540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Mateo, E. J. Brown, G. Biron, M. Rubio, A. Fischer, F. L. Deist, and M. Sarfati Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization Blood, September 26, 2002; 100(8): 2882 - 2890. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
