HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yoshida, H. Articles by Nishikawa, S.-I. Search for Related Content PubMed PubMed Citation Articles by Yoshida, H. Articles by Nishikawa, S.-I.

Expression of ₄₇ Integrin Defines a Distinct Pathway of Lymphoid Progenitors Committed to T Cells, Fetal Intestinal Lymphotoxin Producer, NK, and Dendritic Cells¹

Hisahiro Yoshida^2,*, Hiroshi Kawamoto, Sybil M. Santee, Hiroyuki Hashi^*, Kenya Honda^*, Satomi Nishikawa^*, Carl F. Ware, Yoshimoto Katsura and Shin-Ichi Nishikawa^*

^* Department of Molecular Genetics, Graduate School of Medicine, and Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo, Kyoto, Japan; and Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121

During embryogenesis, the Peyer’s patch anlagen are induced by a cell population that produces lymphotoxin (LT) ₁₂ following stimulation of IL-7R. In this study, we show that the LT-producing cell is localized within the IL-7R⁺ and integrin ₄₇ (₄₇)⁺ population in the embryonic intestine. Lineage commitment to the LT producer phenotype in the fetal liver coincides with expression of ₄₇. Before expression of ₄₇, the potential of IL-7R⁺ population to generate B cells is lost. However, the progenitors for T cells and LT producer cells reside in the IL-7R⁺₄₇⁺ cells, but during subsequent differentiation, the potential to give rise to T cells is lost. This IL-7R⁺₄₇⁺ population migrates to the intestine, where it induces the Peyer’s patch anlagen. When stimulated with IL-15 or IL-3 and TNF, the intestinal IL-7R⁺₄₇⁺ population can differentiate into fully competent NK1.1⁺ NK cells or CD11c⁺ APCs. Expression of ₄₇ is lost during differentiation of both lineages; IL-7R expression is lost during NK1.1⁺ cells differentiation. A newly discovered lineage^-IL-7R⁺c-Kit⁺₄₇⁺ population in the fetal liver is committed to T, NK, dendritic, and fetal intestinal LT producer lineage, the latter being an intermediate stage during differentiation of NK and dendritic cells.

This article has been cited by other articles:

				N. H. Ruddle and E. M. Akirav Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response J. Immunol., August 15, 2009; 183(4): 2205 - 2212. [Abstract] [Full Text] [PDF]

				S. Schmutz, N. Bosco, S. Chappaz, O. Boyman, H. Acha-Orbea, R. Ceredig, A. G. Rolink, and D. Finke Cutting Edge: IL-7 Regulates the Peripheral Pool of Adult ROR{gamma}+ Lymphoid Tissue Inducer Cells J. Immunol., August 15, 2009; 183(4): 2217 - 2221. [Abstract] [Full Text] [PDF]

				D H Adams, B Eksteen, and S M Curbishley Immunology of the gut and liver: a love/hate relationship Gut, June 1, 2008; 57(6): 838 - 848. [Full Text] [PDF]

				M. Okuda, A. Togawa, H. Wada, and S.-i. Nishikawa Distinct Activities of Stromal Cells Involved in the Organogenesis of Lymph Nodes and Peyer's Patches J. Immunol., July 15, 2007; 179(2): 804 - 811. [Abstract] [Full Text] [PDF]

				F. Stevenaert, K. Van Beneden, V. De Colvenaer, A. S. Franki, V. Debacker, T. Boterberg, D. Deforce, K. Pfeffer, J. Plum, D. Elewaut, et al. Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-{beta} receptor expression Blood, August 1, 2005; 106(3): 956 - 962. [Abstract] [Full Text] [PDF]

				T. Cupedo, M. F. R. Vondenhoff, E. J. Heeregrave, A. E. de Weerd, W. Jansen, D. G. Jackson, G. Kraal, and R. E. Mebius Presumptive Lymph Node Organizers are Differentially Represented in Developing Mesenteric and Peripheral Nodes J. Immunol., September 1, 2004; 173(5): 2968 - 2975. [Abstract] [Full Text] [PDF]

				G. Eberl and D. R. Littman Thymic Origin of Intestinal {alpha}{beta} T Cells Revealed by Fate Mapping of ROR{gamma}t+ Cells Science, July 9, 2004; 305(5681): 248 - 251. [Abstract] [Full Text] [PDF]

				H.-J. Kim, T. Kammertoens, M. Janke, O. Schmetzer, Z. Qin, C. Berek, and T. Blankenstein Establishment of Early Lymphoid Organ Infrastructure in Transplanted Tumors Mediated by Local Production of Lymphotoxin {alpha} and in the Combined Absence of Functional B and T Cells J. Immunol., April 1, 2004; 172(7): 4037 - 4047. [Abstract] [Full Text] [PDF]

				T W Spahn and T Kucharzik Modulating the intestinal immune system: the role of lymphotoxin and GALT organs Gut, March 1, 2004; 53(3): 456 - 465. [Full Text] [PDF]

				R. G. Lorenz, D. D. Chaplin, K. G. McDonald, J. S. McDonough, and R. D. Newberry Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin {beta} Receptor, and TNF Receptor I Function J. Immunol., June 1, 2003; 170(11): 5475 - 5482. [Abstract] [Full Text] [PDF]

				D. V. Kuprash, M. B. Alimzhanov, A. V. Tumanov, S. I. Grivennikov, A. N. Shakhov, L. N. Drutskaya, M. W. Marino, R. L. Turetskaya, A. O. Anderson, K. Rajewsky, et al. Redundancy in Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) Signaling In Vivo: Mice with Inactivation of the Entire TNF/LT Locus versus Single-Knockout Mice Mol. Cell. Biol., December 15, 2002; 22(24): 8626 - 8634. [Abstract] [Full Text] [PDF]

				J. L. Browning and L. E. French Visualization of Lymphotoxin-{beta} and Lymphotoxin-{beta} Receptor Expression in Mouse Embryos J. Immunol., May 15, 2002; 168(10): 5079 - 5087. [Abstract] [Full Text] [PDF]