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The Journal of Immunology, 2001, 167: 2361-2369.
Copyright © 2001 by The American Association of Immunologists

Increased Frequency of Pre-germinal Center B Cells and Plasma Cell Precursors in the Blood of Children with Systemic Lupus Erythematosus1

Edsel Arce*,{dagger}, Deborah G. Jackson*,{dagger}, Michelle A. Gill*,{dagger}, Lynda B. Bennett*,{dagger}, Jacques Banchereau* and Virginia Pascual2,*,{dagger}

* Baylor Institute for Immunology Research, Dallas, TX 75204; and {dagger} Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390

We have analyzed the blood B cell subpopulations of children with systemic lupus erythematosus (SLE) and healthy controls. We found that the normal recirculating mature B cell pool is composed of four subsets: conventional naive and memory B cells, a novel B cell subset with pregerminal center phenotype (IgD+CD38+centerin+), and a plasma cell precursor subset (CD20-CD19+/lowCD27+/++ CD38++). In SLE patients, naive and memory B cells (CD20+CD38-) are ~90% reduced, whereas oligoclonal plasma cell precursors are 3-fold expanded, independently of disease activity and modality of therapy. Pregerminal center cells in SLE are decreased to a lesser extent than conventional B cells, and therefore represent the predominant blood B cell subset in a number of patients. Thus, SLE is associated with major blood B cell subset alterations.




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