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1
,
*
Department of Dermatology and
Institute for Clinical and Molecular Virology, University of Erlangen-Nürnberg, Erlangen, Germany; and
Department of Neuroimmunology, Max Planck Institute for Neurobiology, Martinsried, Germany
Signaling lymphocyte activation molecule (SLAM), a 70-kDa
costimulatory molecule that mediates CD28-independent proliferation of
T cells and IFN-
production, has been identified on human T cells,
immature thymocytes, and a subset of B cells. We have found that SLAM
is expressed on mature but not immature dendritic cells (DC). However,
the SLAM-associated protein, is missing in DC. SLAM surface
expression is strongly up-regulated by IL-1
. Addition of IL-1 to
the DC maturation mixture also increases the stimulatory properties of
DC. These findings provide a new marker for DC maturation and help to
explain two areas of DC biology. First, SLAM is a receptor for the
measles virus, previously shown to infect DC. Second, SLAM could
possibly contribute to the enhanced immunostimulatory functions of DC
that are observed following the addition of
IL-1.
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