| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
Whether dendritic cells (DC) play a passive or active role in Th2 response induction is poorly understood. In this study, we show that CD8- DC pulsed with Th2-polarizing Ag (soluble egg Ag (SEA)) from Schistosoma mansoni potently stimulate Th2 responses in vivo and in vitro while failing to undergo a conventional maturation process. Thus, in contrast to DC pulsed with the Th1 response inducing Ag Propionebacterium acnes, SEA-exposed DC exhibit a phenotype that is most similar to that of immature DC, failing to up-regulate expression of CD40, CD54, CD80, CD86, or OX40L; producing no detectable IL-4, IL-10, or IL-12; and displaying only a minor increase in MHC class II expression. Importantly, in vitro derived DC exposed to SEA were phenotypically similar to CD8- DC isolated from active S. mansoni infection. By discriminating between different types of pathogen and responding appropriately, CD8- DC play a major role in the decision process to mount either a Th1 or Th2 response.
This article has been cited by other articles:
|
|
 |
|
  I. van Die and R. D Cummings Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response? Glycobiology, January 1, 2010; 20(1): 2 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Motamedi, S. Arab, S. M. Moazzeni, M. Khamis Abadi, and J. Hadjati Improvement of a Dendritic Cell-Based Therapeutic Cancer Vaccine with Components of Toxoplasma gondii Clin. Vaccine Immunol., October 1, 2009; 16(10): 1393 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Everts, G. Perona-Wright, H. H. Smits, C. H. Hokke, A. J. van der Ham, C. M. Fitzsimmons, M. J. Doenhoff, J. van der Bosch, K. Mohrs, H. Haas, et al. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses J. Exp. Med., August 3, 2009; 206(8): 1673 - 1680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Steinfelder, J. F. Andersen, J. L. Cannons, C. G. Feng, M. Joshi, D. Dwyer, P. Caspar, P. L. Schwartzberg, A. Sher, and D. Jankovic The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1) J. Exp. Med., August 3, 2009; 206(8): 1681 - 1690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Zaretsky, J. J. Taylor, I. L. King, F. A. Marshall, M. Mohrs, and E. J. Pearce T follicular helper cells differentiate from Th2 cells in response to helminth antigens J. Exp. Med., May 11, 2009; 206(5): 991 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Saunders, C. M. Walsh, J. L. Barlow, N. E. Mangan, P. R. Taylor, A. N. J. McKenzie, P. Smith, and P. G. Fallon The C-Type Lectin SIGNR1 Binds Schistosoma mansoni Antigens In Vitro, but SIGNR1-Deficient Mice Have Normal Responses during Schistosome Infection Infect. Immun., January 1, 2009; 77(1): 399 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Shainheit, P. M. Smith, L. E. Bazzone, A. C. Wang, L. I. Rutitzky, and M. J. Stadecker Dendritic Cell IL-23 and IL-1 Production in Response to Schistosome Eggs Induces Th17 Cells in a Mouse Strain Prone to Severe Immunopathology J. Immunol., December 15, 2008; 181(12): 8559 - 8567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kane, E. Jung, and E. J. Pearce Schistosoma mansoni Egg Antigen-Mediated Modulation of Toll-Like Receptor (TLR)-Induced Activation Occurs Independently of TLR2, TLR4, and MyD88 Infect. Immun., December 1, 2008; 76(12): 5754 - 5759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Marshall and E. J. Pearce Uncoupling of Induced Protein Processing from Maturation in Dendritic Cells Exposed to a Highly Antigenic Preparation from a Helminth Parasite J. Immunol., December 1, 2008; 181(11): 7562 - 7570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Krawczyk, J. Sun, and E. J. Pearce Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells J. Immunol., June 15, 2008; 180(12): 7931 - 7937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Jenkins, G. Perona-Wright, and A. S. MacDonald Full Development of Th2 Immunity Requires Both Innate and Adaptive Sources of CD154 J. Immunol., June 15, 2008; 180(12): 8083 - 8092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. McKee, M. MacLeod, J. White, F. Crawford, J. W. Kappler, and P. Marrack Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses Int. Immunol., May 1, 2008; 20(5): 659 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, Q. Chen, S. B. Su, P. Zhang, K. Kurosaka, R. R. Caspi, S. M. Michalek, H. F. Rosenberg, N. Zhang, and J. J. Oppenheim Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses J. Exp. Med., January 21, 2008; 205(1): 79 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. MacDonald and R. M. Maizels Alarming dendritic cells for Th2 induction J. Exp. Med., January 21, 2008; 205(1): 13 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Jenkins, G. Perona-Wright, A. G. F. Worsley, N. Ishii, and A. S. MacDonald Dendritic Cell Expression of OX40 Ligand Acts as a Costimulatory, Not Polarizing, Signal for Optimal Th2 Priming and Memory Induction In Vivo J. Immunol., September 15, 2007; 179(6): 3515 - 3523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Perona-Wright, S. M. Anderton, S. E. M. Howie, and D. Gray IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease Int. Immunol., September 1, 2007; 19(9): 1123 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schramm, K. Mohrs, M. Wodrich, M. J. Doenhoff, E. J. Pearce, H. Haas, and M. Mohrs Cutting Edge: IPSE/alpha-1, a Glycoprotein from Schistosoma mansoni Eggs, Induces IgE-Dependent, Antigen-Independent IL-4 Production by Murine Basophils In Vivo J. Immunol., May 15, 2007; 178(10): 6023 - 6027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Ekkens, D. J. Shedlock, E. Jung, A. Troy, E. L. Pearce, H. Shen, and E. J. Pearce Th1 and Th2 Cells Help CD8 T-Cell Responses Infect. Immun., May 1, 2007; 75(5): 2291 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Hassan, Y. Zhang, C. R. Engwerda, P. M. Kaye, H. Sharp, and Q. D. Bickle The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani Am. J. Pathol., September 1, 2006; 169(3): 943 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Taylor, M. Mohrs, and E. J. Pearce Regulatory T Cell Responses Develop in Parallel to Th Responses and Control the Magnitude and Phenotype of the Th Effector Populatio J. Immunol., May 15, 2006; 176(10): 5839 - 5847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Roghanian, S. E. Williams, T. A. Sheldrake, T. I. Brown, K. Oberheim, Z. Xing, S. E. M. Howie, and J.-M. Sallenave The Antimicrobial/Elastase Inhibitor Elafin Regulates Lung Dendritic Cells and Adaptive Immunity Am. J. Respir. Cell Mol. Biol., May 1, 2006; 34(5): 634 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Leech and R. K. Grencis Induction of Enhanced Immunity to Intestinal Nematodes Using IL-9-Producing Dendritic Cells J. Immunol., February 15, 2006; 176(4): 2505 - 2511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Chen, S. Louie, B. A. McCormick, W. A. Walker, and H. N. Shi Helminth-Primed Dendritic Cells Alter the Host Response to Enteric Bacterial Infection J. Immunol., January 1, 2006; 176(1): 472 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. Chu and C. A. Lowell The Lyn Tyrosine Kinase Differentially Regulates Dendritic Cell Generation and Maturation J. Immunol., September 1, 2005; 175(5): 2880 - 2889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Renkl, J. Wussler, T. Ahrens, K. Thoma, S. Kon, T. Uede, S. F. Martin, J. C. Simon, and J. M. Weiss Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype Blood, August 1, 2005; 106(3): 946 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Su, M. Segura, K. Morgan, J. C. Loredo-Osti, and M. M. Stevenson Impairment of Protective Immunity to Blood-Stage Malaria by Concurrent Nematode Infection Infect. Immun., June 1, 2005; 73(6): 3531 - 3539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Artis, C. M. Kane, J. Fiore, C. Zaph, S. Shapira, K. Joyce, A. MacDonald, C. Hunter, P. Scott, and E. J. Pearce Dendritic Cell-Intrinsic Expression of NF-{kappa}B1 Is Required to Promote Optimal Th2 Cell Differentiation J. Immunol., June 1, 2005; 174(11): 7154 - 7159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bennouna and E. Y. Denkers Microbial Antigen Triggers Rapid Mobilization of TNF-{alpha} to the Surface of Mouse Neutrophils Transforming Them into Inducers of High-Level Dendritic Cell TNF-{alpha} Production J. Immunol., April 15, 2005; 174(8): 4845 - 4851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Marcenaro, M. D. Chiesa, F. Bellora, S. Parolini, R. Millo, L. Moretta, and A. Moretta IL-12 or IL-4 Prime Human NK Cells to Mediate Functionally Divergent Interactions with Dendritic Cells or Tumors J. Immunol., April 1, 2005; 174(7): 3992 - 3998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pulendran Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors J. Immunol., March 1, 2005; 174(5): 2457 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, M. Walsh, A. V. Villarino, L. Cervi, C. A. Hunter, Y. Choi, and E. J. Pearce TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development J. Immunol., January 15, 2005; 174(2): 742 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Q. Khan, Q. Chen, Z.-Q. Wu, J. C. Paton, and C. M. Snapper Both Innate Immunity and Type 1 Humoral Immunity to Streptococcus pneumoniae Are Mediated by MyD88 but Differ in Their Relative Levels of Dependence on Toll-Like Receptor 2 Infect. Immun., January 1, 2005; 73(1): 298 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Jenkins and A. P. Mountford Dendritic Cells Activated with Products Released by Schistosome Larvae Drive Th2-Type Immune Responses, Which Can Be Inhibited by Manipulation of CD40 Costimulation Infect. Immun., January 1, 2005; 73(1): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kane, L. Cervi, J. Sun, A. S. McKee, K. S. Masek, S. Shapira, C. A. Hunter, and E. J. Pearce Helminth Antigens Modulate TLR-Initiated Dendritic Cell Activation J. Immunol., December 15, 2004; 173(12): 7454 - 7461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Hengesbach and K. A. Hoag Physiological Concentrations of Retinoic Acid Favor Myeloid Dendritic Cell Development over Granulocyte Development in Cultures of Bone Marrow Cells from Mice J. Nutr., October 1, 2004; 134(10): 2653 - 2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jankovic, M. C. Kullberg, P. Caspar, and A. Sher Parasite-Induced Th2 Polarization Is Associated with Down-Regulated Dendritic Cell Responsiveness to Th1 Stimuli and a Transient Delay in T Lymphocyte Cycling J. Immunol., August 15, 2004; 173(4): 2419 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. McKee, F. Dzierszinski, M. Boes, D. S. Roos, and E. J. Pearce Functional Inactivation of Immature Dendritic Cells by the Intracellular Parasite Toxoplasma gondii J. Immunol., August 15, 2004; 173(4): 2632 - 2640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. McKee and E. J. Pearce CD25+CD4+ Cells Contribute to Th2 Polarization during Helminth Infection by Suppressing Th1 Response Development J. Immunol., July 15, 2004; 173(2): 1224 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ramirez-Pineda, A. Frohlich, C. Berberich, and H. Moll Dendritic Cells (DC) Activated by CpG DNA Ex Vivo Are Potent Inducers of Host Resistance to an Intracellular Pathogen That Is Independent of IL-12 Derived from the Immunizing DC J. Immunol., May 15, 2004; 172(10): 6281 - 6289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mazzoni and D. M. Segal Controlling the Toll road to dendritic cell polarization J. Leukoc. Biol., May 1, 2004; 75(5): 721 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dillon, A. Agrawal, T. Van Dyke, G. Landreth, L. McCauley, A. Koh, C. Maliszewski, S. Akira, and B. Pulendran A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells J. Immunol., April 15, 2004; 172(8): 4733 - 4743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yasumi, K. Katamura, T. Yoshioka, T.-a. Meguro, R. Nishikomori, T. Heike, M. Inobe, S. Kon, T. Uede, and T. Nakahata Differential Requirement for the CD40-CD154 Costimulatory Pathway during Th Cell Priming by CD8{alpha}+ and CD8{alpha}− Murine Dendritic Cell Subsets J. Immunol., April 15, 2004; 172(8): 4826 - 4833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Chiu, C. M. Freeman, V. R. Stolberg, J. S. Hu, E. Komuniecki, and S. W. Chensue The Innate Pulmonary Granuloma: Characterization and Demonstration of Dendritic Cell Recruitment and Function Am. J. Pathol., March 1, 2004; 164(3): 1021 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cervi, A. S. MacDonald, C. Kane, F. Dzierszinski, and E. J. Pearce Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses J. Immunol., February 15, 2004; 172(4): 2016 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Thomas, M. R. Carter, O. Atochina, A. A. Da'Dara, D. Piskorska, E. McGuire, and D. A. Harn Maturation of Dendritic Cell 2 Phenotype by a Helminth Glycan Uses a Toll-Like Receptor 4-Dependent Mechanism J. Immunol., December 1, 2003; 171(11): 5837 - 5841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bennouna, S. K. Bliss, T. J. Curiel, and E. Y. Denkers Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection J. Immunol., December 1, 2003; 171(11): 6052 - 6058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Agrawal, A. Agrawal, B. Doughty, A. Gerwitz, J. Blenis, T. Van Dyke, and B. Pulendran Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos J. Immunol., November 15, 2003; 171(10): 4984 - 4989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Doxsee, T. R. Riter, M. J. Reiter, S. J. Gibson, J. P. Vasilakos, and R. M. Kedl The Immune Response Modifier and Toll-Like Receptor 7 Agonist S-27609 Selectively Induces IL-12 and TNF-{alpha} Production in CD11c+CD11b+CD8- Dendritic Cells J. Immunol., August 1, 2003; 171(3): 1156 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. van Die, S. J. van Vliet, A. K. Nyame, R. D. Cummings, C. M.C. Bank, B. Appelmelk, T. B.H. Geijtenbeek, and Y. van Kooyk The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x Glycobiology, June 1, 2003; 13(6): 471 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. Dodge, M. W. Carr, M. Cernadas, and M. B. Brenner IL-6 Production by Pulmonary Dendritic Cells Impedes Th1 Immune Responses J. Immunol., May 1, 2003; 170(9): 4457 - 4464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Shedlock, J. K. Whitmire, J. Tan, A. S. MacDonald, R. Ahmed, and H. Shen Role of CD4 T Cell Help and Costimulation in CD8 T Cell Responses During Listeria monocytogenes Infection J. Immunol., February 15, 2003; 170(4): 2053 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Slager, M. Borghi, C. E. van der Minne, C. A. Aarnoudse, M. J. E. Havenga, P. I. Schrier, S. Osanto, and M. Griffioen CD4+ Th2 Cell Recognition of HLA-DR-Restricted Epitopes Derived from CAMEL: A Tumor Antigen Translated in an Alternative Open Reading Frame J. Immunol., February 1, 2003; 170(3): 1490 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Straw, A. S. MacDonald, E. Y. Denkers, and E. J. Pearce CD154 Plays a Central Role in Regulating Dendritic Cell Activation During Infections That Induce Th1 or Th2 Responses J. Immunol., January 15, 2003; 170(2): 727 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Geldhof, J. A. Van Ginderachter, Y. Liu, W. Noel, G. Raes, and P. De Baetselier Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation Blood, December 1, 2002; 100(12): 4049 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Stephens and D. D. Chaplin IgE Cross-Linking or Lipopolysaccharide Treatment Induces Recruitment of Th2 Cells to the Lung in the Absence of Specific Antigen J. Immunol., November 15, 2002; 169(10): 5468 - 5476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Faveeuw, V. Angeli, J. Fontaine, C. Maliszewski, A. Capron, L. Van Kaer, M. Moser, M. Capron, and F. Trottein Antigen Presentation by CD1d Contributes to the Amplification of Th2 Responses to Schistosoma mansoni Glycoconjugates in Mice J. Immunol., July 15, 2002; 169(2): 906 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodriguez-Sosa, A. R. Satoskar, R. Calderon, L. Gomez-Garcia, R. Saavedra, R. Bojalil, and L. I. Terrazas Chronic Helminth Infection Induces Alternatively Activated Macrophages Expressing High Levels of CCR5 with Low Interleukin-12 Production and Th2-Biasing Ability Infect. Immun., July 1, 2002; 70(7): 3656 - 3664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kaisho, K. Hoshino, T. Iwabe, O. Takeuchi, T. Yasui, and S. Akira Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation Int. Immunol., July 1, 2002; 14(7): 695 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. MacDonald and E. J. Pearce Cutting Edge: Polarized Th Cell Response Induction by Transferred Antigen-Pulsed Dendritic Cells Is Dependent on IL-4 or IL-12 Production by Recipient Cells J. Immunol., April 1, 2002; 168(7): 3127 - 3130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. MacDonald, A. D. Straw, N. M. Dalton, and E. J. Pearce Cutting Edge: Th2 Response Induction by Dendritic Cells: A Role for CD40 J. Immunol., January 15, 2002; 168(2): 537 - 540. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
