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The Journal of Immunology, 2001, 167: 1970-1976.
Copyright © 2001 by The American Association of Immunologists

Human Recent Thymic Emigrants–Identification, Expansion, And Survival Characteristics

Jaythoon Hassan1,* and Denis J. Reen*,{dagger}

* Children’s Research Centre, Our Lady’s Hospital for Sick Children, Dublin, Ireland; and {dagger} Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, Ireland.

This study shows that, in humans at birth, circulating T cells represent recent thymic emigrants (RTEs) as reflected in their high level of expression of TCR excision circles. RTEs express "thymocyte-like" characteristics with regard to rapid rate of apoptosis. In the presence of common {gamma}-chain cytokines, in particular IL-7, they show enhanced potential to survive, entry into cell cycle, and proliferation. Although common {gamma}-chain cytokines were also potent antiapoptotic stimuli for mature adult-derived naive CD4+CD45RA+ T cells, these cells were refractory to IL-7-induced expansion in vitro. RTEs cultured with IL-7 could not reinduce recombination-activating gene-2 gene expression in vitro. These data suggest that postthymic naive T cells in the periphery during early life are at a unique stage in ontogeny as RTEs, during which they can undergo homeostatic regulation including expansion and survival in an Ag-independent manner while maintaining their preselected TCR repertoire.




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