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Impairment in the Expression and Activity of Fyn During Differentiation of Naive CD4⁺ T Cells into the Th2 Subset¹

Toshiki Tamura^2,*, Osamu Igarashi^*, Ayako Hino^*, Hidehiro Yamane^*, Shinichi Aizawa, Takuma Kato^* and Hideo Nariuchi^3,*

^* Department of Allergology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; and Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Japan

We previously showed that the amounts of Fyn protein in Th2 clones were approximately one-third to one-fifth of those in Th1 clones. In this study we examined the role of Fyn in the polarization of naive CD4⁺ T cells toward the Th2 subset using fyn^-/- mice. The fyn^-/- naive CD4⁺ T cells efficiently produced Th2 cytokines and polarized toward the Th2 subset even in the absence of IL-4 and IL-13. The expression of Fyn in wild-type CD4⁺ T cells decreased at a transcription level concomitant with polarization toward the Th2 subset. These results suggest that Fyn plays a role in the down-regulation of the differentiation of naive CD4⁺ T cells into the Th2 subset.

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