HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tamura, T. Articles by Nariuchi, H. Search for Related Content PubMed PubMed Citation Articles by Tamura, T. Articles by Nariuchi, H.

Impairment in the Expression and Activity of Fyn During Differentiation of Naive CD4⁺ T Cells into the Th2 Subset¹

Toshiki Tamura^2,*, Osamu Igarashi^*, Ayako Hino^*, Hidehiro Yamane^*, Shinichi Aizawa, Takuma Kato^* and Hideo Nariuchi^3,*

^* Department of Allergology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; and Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Japan

We previously showed that the amounts of Fyn protein in Th2 clones were approximately one-third to one-fifth of those in Th1 clones. In this study we examined the role of Fyn in the polarization of naive CD4⁺ T cells toward the Th2 subset using fyn^-/- mice. The fyn^-/- naive CD4⁺ T cells efficiently produced Th2 cytokines and polarized toward the Th2 subset even in the absence of IL-4 and IL-13. The expression of Fyn in wild-type CD4⁺ T cells decreased at a transcription level concomitant with polarization toward the Th2 subset. These results suggest that Fyn plays a role in the down-regulation of the differentiation of naive CD4⁺ T cells into the Th2 subset.

This article has been cited by other articles:

				A. A. Mamchak, B. M. Sullivan, B. Hou, L. M. Lee, J. K. Gilden, M. F. Krummel, R. M. Locksley, and A. L. DeFranco Normal Development and Activation but Altered Cytokine Production of Fyn-Deficient CD4+ T Cells J. Immunol., October 15, 2008; 181(8): 5374 - 5385. [Abstract] [Full Text] [PDF]

				B. Gomes, M. Savignac, M. D. Cabral, P. Paulet, M. Moreau, C. Leclerc, R. Feil, F. Hofmann, J.-C. Guery, G. Dietrich, et al. The cGMP/Protein Kinase G Pathway Contributes to Dihydropyridine-sensitive Calcium Response and Cytokine Production in TH2 Lymphocytes J. Biol. Chem., May 5, 2006; 281(18): 12421 - 12427. [Abstract] [Full Text] [PDF]

				K. Shibuya, J. Shirakawa, T. Kameyama, S.-i. Honda, S. Tahara-Hanaoka, A. Miyamoto, M. Onodera, T. Sumida, H. Nakauchi, H. Miyoshi, et al. CD226 (DNAM-1) Is Involved in Lymphocyte Function-associated Antigen 1 Costimulatory Signal for Naive T Cell Differentiation and Proliferation J. Exp. Med., December 15, 2003; 198(12): 1829 - 1839. [Abstract] [Full Text] [PDF]

				C. B. Stephensen, R. Rasooly, X. Jiang, M. A. Ceddia, C. T. Weaver, R. A. S. Chandraratna, and R. P. Bucy Vitamin A Enhances in Vitro Th2 Development Via Retinoid X Receptor Pathway J. Immunol., May 1, 2002; 168(9): 4495 - 4503. [Abstract] [Full Text] [PDF]