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T Cells1
*
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan;
Department of Dermatology, Niigata University School of Medicine, Niigata, Japan;
Department of Immunology, Graduate School of Medicine, Nagoya University, Nagoya, Japan;
Amgen Institute, Toronto, Ontario, Canada; and
¶ Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305
IL-7 and IL-15 play important roles in 
T cell development.
These receptors transmit proliferation and/or survival signals in
T cells. In addition, the IL-7R promotes recombination and
transcription in the TCR locus. To clarify the role of the cytokine
receptors in the development of epidermal T cells, we introduced
a V3/V1 TCR transgene, derived from Thy-1+
dendritic epidermal T cells (DETC), into IL-7R
-deficient mice, and
we found that they partly rescued T cells in the adult thymus
but not in the spleen. Introduction of an additional Bcl-2 transgene
had a minimal effect on T cells in the adult thymus of these
mice. In contrast to the adult thymus, the introduction of the
V3/V1 TCR transgene into IL-7R-/- mice
completely restored V3+ T cells in the fetal thymus and
DETC in the adult skin. On the contrary, the same V3/V1 TCR
transgene failed to rescue DETC in the skin of IL-2R
-deficient mice,
even with the additional Bcl-2 transgene. These results suggest that
the IL-2/IL-15R, rather than the IL-7R, plays an essential role in
proliferation and survival of DETC in the fetal thymus and the skin. In
contrast, the IL-7R is probably essential in the induction of V-J
recombination of TCR genes. Thus, this study proves that IL-7R and
IL-2/IL-15R serve differential functions in epidermal T cell
development.
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