| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Rheumatology Section, Imperial College School of Medicine, London, United Kingdom;
Department of Histopathology, St Mary’s Hospital, London, United Kingdom; and
Department of Pathology, Centre Médical Universitaire, Geneva, Switzerland
B.J.M and M.J.W. and from the Swiss National Foundation for Scientific Research (to S.I.). M.E.K.H. was a recipient of an Arthritis Research Campaign PhD studentship, and T.J.V. is a Wellcome Trust Senior Clinical Research Fellow.
Retroviral envelope glycoprotein gp70 is present in the sera of
immunologically normal and autoimmune-prone strains of mice. However,
only lupus-prone mice spontaneously develop gp70-anti-gp70 immune
complexes (gp70IC), and these have been implicated in the development
of nephritis. We investigated the genetic factors that affect the
production of both free serum gp70 and gp70IC in the lupus-prone BXSB
mouse strain by analyzing (BXSB x (C57BL/10 x
BXSB)F1)- and (C57BL/10 x (C57BL/10 x
BXSB)F1)-backcrossed male mice. Production of gp70 mapped
to a single major locus located on chromosome 13 (Bxs6)
with a maximum log likelihood of the odds of 36.7
(p = 1.6 x 10-38). The level of
gp70IC was highly dependent on Bxs6-related gp70
production, and high titer autoantibody production only occurred when
serum gp70 levels were greater than a threshold value of 
4.0
µg/ml. The subdivision of the (BXSB x (C57BL/10 x
BXSB)F1)-backcrossed mice into those homozygous or
heterozygous for Bxs6 enabled a remarkable association
to be observed between high levels of gp70IC and severe nephritis in
the Bxs6 homozygote population. A further mapping study
in these two subgroups identified a previously unrecognized interval
associated with the production of
autoantibodies.
This article has been cited by other articles:
|
|
 |
|
  K. Yoshinobu, L. Baudino, M.-L. Santiago-Raber, N. Morito, I. Dunand-Sauthier, B. J. Morley, L. H. Evans, and S. Izui Selective Up-Regulation of Intact, but Not Defective env RNAs of Endogenous Modified Polytropic Retrovirus by the Sgp3 Locus of Lupus-Prone Mice J. Immunol., June 15, 2009; 182(12): 8094 - 8103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Martinez-Soria, M.-L. Santiago-Raber, L. Ho, T. Moll, and S. Izui Protection of Murine Systemic Lupus by the Ea Transgene without Expression of I-E Heterodimers J. Immunol., September 1, 2008; 181(5): 3651 - 3657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Baudino, K. Yoshinobu, N. Morito, S. Kikuchi, L. Fossati-Jimack, B. J. Morley, T. J. Vyse, S. Hirose, T. N. Jorgensen, R. M. Tucker, et al. Dissection of Genetic Mechanisms Governing the Expression of Serum Retroviral gp70 Implicated in Murine Lupus Nephritis J. Immunol., August 15, 2008; 181(4): 2846 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. K. Haywood, L. Gabriel, S. J. Rose, N. J. Rogers, S. Izui, and B. J. Morley BXSB/long-lived Is a Recombinant Inbred Strain Containing Powerful Disease Suppressor Loci J. Immunol., August 15, 2007; 179(4): 2428 - 2434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rankin, J. J. Boyle, S. J. Rose, L. Gabriel, M. Lewis, V. Thiruudaian, N. J. Rogers, S. Izui, and B. J. Morley The Bxs6 Locus of BXSB Mice Is Sufficient for High-Level Expression of gp70 and the Production of gp70 Immune Complexes J. Immunol., April 1, 2007; 178(7): 4395 - 4401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Tucker, M. M. Mellencamp, M. Donadeu, and L. Scobie Retroviremia in commercial pigs and its preliminary association with poor health. J. Clin. Microbiol., October 1, 2006; 44(10): 3846 - 3847. [Full Text] [PDF]
|
|
|
|
|
|
Y. Hamano, K. Tsukamoto, M. Abe, G. D. Sun, D. Zhang, H. Fujii, S. Matsuoka, M. Tanaka, A. Ishida-Okawara, H. Tachikawa, et al. Genetic Dissection of Vasculitis, Myeloperoxidase-Specific Antineutrophil Cytoplasmic Autoantibody Production, and Related Traits in Spontaneous Crescentic Glomerulonephritis-Forming/Kinjoh Mice J. Immunol., March 15, 2006; 176(6): 3662 - 3673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Wither, C. Loh, G. Lajoie, S. Heinrichs, Y.-C. Cai, G. Bonventi, and R. MacLeod Colocalization of Expansion of the Splenic Marginal Zone Population with Abnormal B Cell Activation and Autoantibody Production in B6 Mice with an Introgressed New Zealand Black Chromosome 13 Interval J. Immunol., October 1, 2005; 175(7): 4309 - 4319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kikuchi, L. Fossati-Jimack, T. Moll, H. Amano, E. Amano, A. Ida, N. Ibnou-Zekri, C. Laporte, M.-L. Santiago-Raber, S. J. Rozzo, et al. Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis J. Immunol., January 15, 2005; 174(2): 1111 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. K. Haywood, N. J. Rogers, S. J. Rose, J. Boyle, A. McDermott, J. M. Rankin, V. Thiruudaian, M. R. Lewis, L. Fossati-Jimack, S. Izui, et al. Dissection of BXSB Lupus Phenotype Using Mice Congenic for Chromosome 1 Demonstrates That Separate Intervals Direct Different Aspects of Disease J. Immunol., October 1, 2004; 173(7): 4277 - 4285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Rigby, S. J. Rozzo, H. Gill, T. Fernandez-Hart, B. J. Morley, S. Izui, B. L. Kotzin, and T. J. Vyse A Novel Locus Regulates Both Retroviral Glycoprotein 70 and Anti-Glycoprotein 70 Antibody Production in New Zealand Mice When Crossed with BALB/c J. Immunol., April 15, 2004; 172(8): 5078 - 5085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Laporte, B. Ballester, C. Mary, S. Izui, and L. Reininger The Sgp3 Locus on Mouse Chromosome 13 Regulates Nephritogenic gp70 Autoantigen Expression and Predisposes to Autoimmunity J. Immunol., October 1, 2003; 171(7): 3872 - 3877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Alexander, A. K. Saxena, L. Bao, A. Jacob, M. Haas, and R. J. Quigg Prominent Renal Expression of a Murine Leukemia Retrovirus in Experimental Systemic Lupus Erythematosus J. Am. Soc. Nephrol., December 1, 2002; 13(12): 2869 - 2877. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
