| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Departments of
*
Medicine and
Pathology, University of California at San Diego, La Jolla, CA 92093; and
Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Bethesda, MD 20892
Immunostimulatory DNA sequences (ISS, also known as CpG motifs) are
pathogen-associated molecular patterns that are potent stimulators of
innate immunity. We tested the ability of ISS to act as an
immunostimulatory pathogen-associated molecular pattern in a model HIV
vaccine using gp120 envelope protein as the Ag. Mice immunized with
gp120 and ISS, or a gp120:ISS conjugate, developed gp120-specific
immune responses which included: 1) Ab production; 2) a Th1-biased
cytokine response; 3) the secretion of 
-chemokines, which are known
to inhibit the use of the CCR5 coreceptor by HIV; 4) CTL activity; 5)
mucosal immune responses; and 6) CD8 T cell responses that were
independent of CD4 T cell help. Based on these results, ISS-based
immunization holds promise for the development of an effective
preventive and therapeutic HIV vaccine.
This article has been cited by other articles:
|
|
 |
|
  A. Jamali, M. Mahdavi, Z. M. Hassan, F. Sabahi, M. J. Farsani, T. Bamdad, H. Soleimanjahi, M. Motazakker, and S. Shahabi A novel adjuvant, the general opioid antagonist naloxone, elicits a robust cellular immune response for a DNA vaccine Int. Immunol., March 1, 2009; 21(3): 217 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Azizi, D. E. Anderson, J. V. Torres, A. Ogrel, M. Ghorbani, C. Soare, P. Sandstrom, J. Fournier, and F. Diaz-Mitoma Induction of Broad Cross-Subtype-Specific HIV-1 Immune Responses by a Novel Multivalent HIV-1 Peptide Vaccine in Cynomolgus Macaques J. Immunol., February 15, 2008; 180(4): 2174 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tse and A. A Horner Update on toll-like receptor-directed therapies for human disease Ann Rheum Dis, November 1, 2007; 66(suppl_3): iii77 - iii80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Khan, M. S. Bijker, J. J. Weterings, H. J. Tanke, G. J. Adema, T. van Hall, J. W. Drijfhout, C. J. M. Melief, H. S. Overkleeft, G. A. van der Marel, et al. Distinct Uptake Mechanisms but Similar Intracellular Processing of Two Different Toll-like Receptor Ligand-Peptide Conjugates in Dendritic Cells J. Biol. Chem., July 20, 2007; 282(29): 21145 - 21159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Belyakov, D. Isakov, Q. Zhu, A. Dzutsev, and J. A. Berzofsky A Novel Functional CTL Avidity/Activity Compartmentalization to the Site of Mucosal Immunization Contributes to Protection of Macaques against Simian/Human Immunodeficiency Viral Depletion of Mucosal CD4+ T Cells J. Immunol., June 1, 2007; 178(11): 7211 - 7221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Wettstein, N. D. Borson, J. G. Park, K. T. McNallan, and A. M. Reed Cysteine-Tailed Class I-Binding Peptides Bind to CpG Adjuvant and Enhance Primary CTL Responses J. Immunol., September 15, 2005; 175(6): 3681 - 3689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Wille-Reece, C.-y. Wu, B. J. Flynn, R. M. Kedl, and R. A. Seder Immunization with HIV-1 Gag Protein Conjugated to a TLR7/8 Agonist Results in the Generation of HIV-1 Gag-Specific Th1 and CD8+ T Cell Responses J. Immunol., June 15, 2005; 174(12): 7676 - 7683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, R. Alvarez, G. Roderiquez, E. Guan, Q. Caldwell, J. Wang, M. Phelan, and M. A. Norcross CpG-Independent Synergistic Induction of {beta}-Chemokines and a Dendritic Cell Phenotype by Orthophosphorothioate Oligodeoxynucleotides and Granulocyte-Macrophage Colony-Stimulating Factor in Elutriated Human Primary Monocytes J. Immunol., May 15, 2005; 174(10): 6113 - 6121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Heit, F. Schmitz, M. O'Keeffe, C. Staib, D. H. Busch, H. Wagner, and K. M. Huster Protective CD8 T Cell Immunity Triggered by CpG-Protein Conjugates Competes with the Efficacy of Live Vaccines J. Immunol., April 1, 2005; 174(7): 4373 - 4380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Bachmann, K. Schwarz, P. Wolint, E. Meijerink, S. Martin, V. Manolova, and A. Oxenius Cutting Edge: Distinct Roles for T Help and CD40/CD40 Ligand in Regulating Differentiation of Proliferation-Competent Memory CD8+ T Cells J. Immunol., August 15, 2004; 173(4): 2217 - 2221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yao, R. Zhang, L. Guo, M. Li, and C. Chen Th Cell-Independent Immune Responses to Chimeric Hemagglutinin/Simian Human Immunodeficiency Virus-Like Particles Vaccine J. Immunol., August 1, 2004; 173(3): 1951 - 1958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mooij, I. G. Nieuwenhuis, C. J. Knoop, R. W. Doms, W. M. J. M. Bogers, P. J. F. ten Haaft, H. Niphuis, W. Koornstra, K. Bieler, J. Kostler, et al. Qualitative T-Helper Responses to Multiple Viral Antigens Correlate with Vaccine-Induced Immunity to Simian/Human Immunodeficiency Virus Infection J. Virol., April 1, 2004; 78(7): 3333 - 3342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fujimoto, Y. Nakagawa, K. Ohara, and H. Takahashi Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes Int. Immunol., January 1, 2004; 16(1): 55 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Nayak, G. Sailaja, and A. M. Jabbar Enhancement of gp120-Specific Immune Responses by Genetic Vaccination with the Human Immunodeficiency Virus Type 1 Envelope Gene Fused to the Gene Coding for Soluble CTLA4 J. Virol., October 15, 2003; 77(20): 10850 - 10861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Daftarian, S. Ali, R. Sharan, S. F. Lacey, C. La Rosa, J. Longmate, C. Buck, R. F. Siliciano, and D. J. Diamond Immunization with Th-CTL Fusion Peptide and Cytosine-Phosphate-Guanine DNA in Transgenic HLA-A2 Mice Induces Recognition of HIV-Infected T Cells and Clears Vaccinia Virus Challenge J. Immunol., October 15, 2003; 171(8): 4028 - 4039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tritel, A. M. Stoddard, B. J. Flynn, P. A. Darrah, C.-y. Wu, U. Wille, J. A. Shah, Y. Huang, L. Xu, M. R. Betts, et al. Prime-Boost Vaccination with HIV-1 Gag Protein and Cytosine Phosphate Guanosine Oligodeoxynucleotide, Followed by Adenovirus, Induces Sustained and Robust Humoral and Cellular Immune Responses J. Immunol., September 1, 2003; 171(5): 2538 - 2547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wuthrich, H. I. Filutowicz, T. Warner, G. S. Deepe Jr., and B. S. Klein Vaccine Immunity to Pathogenic Fungi Overcomes the Requirement for CD4 Help in Exogenous Antigen Presentation to CD8+ T Cells: Implications for Vaccine Development in Immune-deficient Hosts J. Exp. Med., June 2, 2003; 197(11): 1405 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. I. Albu, A. Jones-Trower, A. M. Woron, K. Stellrecht, C. C. Broder, and D. W. Metzger Intranasal Vaccination Using Interleukin-12 and Cholera Toxin Subunit B as Adjuvants To Enhance Mucosal and Systemic Immunity to Human Immunodeficiency Virus Type 1 Glycoproteins J. Virol., May 15, 2003; 77(10): 5589 - 5597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Equils, M. L. Schito, H. Karahashi, Z. Madak, A. Yarali, K. S. Michelsen, A. Sher, and M. Arditi Toll-Like Receptor 2 (TLR2) and TLR9 Signaling Results in HIV-Long Terminal Repeat Trans-Activation and HIV Replication in HIV-1 Transgenic Mouse Spleen Cells: Implications of Simultaneous Activation of TLRs on HIV Replication J. Immunol., May 15, 2003; 170(10): 5159 - 5164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Kumaraguru, C. D. Pack, and B. T. Rouse Toll-like receptor ligand links innate and adaptive immune responses by the production of heat-shock proteins J. Leukoc. Biol., May 1, 2003; 73(5): 574 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Blackwell and A. M. Krieg CpG-A-Induced Monocyte IFN-{gamma}-Inducible Protein-10 Production Is Regulated by Plasmacytoid Dendritic Cell-Derived IFN-{alpha} J. Immunol., April 15, 2003; 170(8): 4061 - 4068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Datta, V. Redecke, K. R. Prilliman, K. Takabayashi, M. Corr, T. Tallant, J. DiDonato, R. Dziarski, S. Akira, S. P. Schoenberger, et al. A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells J. Immunol., April 15, 2003; 170(8): 4102 - 4110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takabayashi, L. Libet, D. Chisholm, J. Zubeldia, and A. A. Horner Intranasal Immunotherapy Is More Effective Than Intradermal Immunotherapy for the Induction of Airway Allergen Tolerance in Th2-Sensitized Mice J. Immunol., April 1, 2003; 170(7): 3898 - 3905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-M. Kang and R. W. Compans Enhancement of Mucosal Immunization with Virus-Like Particles of Simian Immunodeficiency Virus J. Virol., March 15, 2003; 77(6): 3615 - 3623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Bergmann, B. Parra, D. R. Hinton, R. Chandran, M. Morrison, and S. A. Stohlman Perforin-Mediated Effector Function Within the Central Nervous System Requires IFN-{gamma}-Mediated MHC Up-Regulation J. Immunol., March 15, 2003; 170(6): 3204 - 3213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. La Rosa, Z. Wang, J. C. Brewer, S. F. Lacey, M. C. Villacres, R. Sharan, R. Krishnan, M. Crooks, S. Markel, R. Maas, et al. Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice Blood, November 15, 2002; 100(10): 3681 - 3689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Biragyn, I. M. Belyakov, Y.-H. Chow, D. S. Dimitrov, J. A. Berzofsky, and L. W. Kwak DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses Blood, July 30, 2002; 100(4): 1153 - 1159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Cho, T. Hayashi, S. K. Datta, K. Takabayashi, J. H. Van Uden, A. Horner, M. Corr, and E. Raz IFN-{alpha}{beta} Promote Priming of Antigen-Specific CD8+ and CD4+ T Lymphocytes by Immunostimulatory DNA-Based Vaccines J. Immunol., May 15, 2002; 168(10): 4907 - 4913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ramakrishna, S. A. Stohlman, R. D. Atkinson, M. J. Shlomchik, and C. C. Bergmann Mechanisms of Central Nervous System Viral Persistence: the Critical Role of Antibody and B Cells J. Immunol., February 1, 2002; 168(3): 1204 - 1211. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
