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*
Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal; and
Department of Pathology, The Portuguese Cancer Institute-Porto Regional Centre, Porto, Portugal
Novel approaches are required for the prevention and therapy of
mycobacterial infections since the only vaccine in use, bacillus
Calmette-Guérin, is poorly effective and chemotherapy is long and
often ineffective in sterilizing the infection. We used a mouse model
of Mycobacterium avium infection to address the
usefulness of a mAb able to block IL-10R both in treatment of primary
infections and in conventional multidrug therapy and subunit
vaccination. Treatment of infected mice with this mAb during the entire
period of experimental infection had little impact on the course of
M. avium infection, with a slight improvement in the
resistance of infected mice observed in the liver and spleen at day 30
of infection, which was associated with increased macrophage activation
and priming of CD4+ T cells for IFN-
production.
Administration of this mAb later in infection had no effect on its
course, but improved the effectiveness of chemotherapy when the latter
was started in a chronic phase of infection. Also, the anti-IL-10R
mAb acted as an adjuvant in the induction of protective immunity upon
vaccination with a mycobacterial subunit
preparation.
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