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The Journal of Immunology, 2001, 167: 1447-1453.
Copyright © 2001 by The American Association of Immunologists

Both TCR{alpha} and TCR{delta} Chain Diversity Are Regulated During Thymic Ontogeny1

Maighréad Gallagher, Patricia Obeïd, Patrice N. Marche2 and Evelyne Jouvin-Marche

Institut National de la Santé et de la Recherche Médical, Unité 548, Commissariat à l’Energie Atomique de Grenoble, Université Joseph Fourier, Grenoble, France

TCR{alpha} and TCR{delta} chains are coded by a common genetic locus using a single set of V gene segments (ADV segments). This article addresses the question of regulation of the use of the ADV segments by the TCR{alpha} and TCR{delta} chains. Using both qualitative and quantitative analyses we have studied the use of 23 ADV gene families as part of TCR{alpha} and TCR{delta} transcripts. A number of previously undetected rearrangement and transcription events are described, indicating that the intrathymic TCR{delta} repertoire is much more diverse than previously supposed. Repertoire analysis at several developmental time points allowed the description of regulated waves of ADV gene use, not only for TCR{delta} chains, but also for TCR{alpha} chains, during thymic ontogeny. Control of these waves appears to be linked directly to the ADV segments and their local chromatin environment, which may change over the course of T cell differentiation.




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