| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Release by Liver NKT Cells1
Departments of
*
Medical Microbiology and Immunology and
Pathology, University of Ulm, Ulm, Germany
A prominent subset of the hepatic innate immune system is
-galactosylceramide (GalCer)-reactive, (CD4+ and
CD4-CD8-) CD1d-restricted NKT cells. We
investigated in C57BL/6 (B6) mice which hepatic cell type stimulates
hepatic NKT cell activation. Surface expression of CD1d but not CD40,
CD80, or CD86 costimulator molecules was detected in hepatocytes.
Pulsed in vitro or in vivo with GalCer, hepatocytes triggered IL-4
release by liver NKT cells but required exogenous IL-12 to trigger
IFN-
release by NKT cells. Liver dendritic cells (DC) isolated from
nontreated mice showed low surface expression of MHC, CD1d, and CD40,
CD80, or CD86 costimulator molecules that were strikingly up-regulated
after GalCer injection. Although liver CD11c+ DC
displayed lower CD1d surface expression than hepatocytes, they were
potent stimulators of IFN- and IL-4 release by liver NKT when pulsed
with GalCer in vitro or in vivo. Liver DC are thus potent
stimulators of proinflammatory cytokine release by NKT cells, are
activated themselves in the process of NKT cell activation, and express
an activated phenotype after the NKT cell population is eliminated
following GalCer stimulation.
This article has been cited by other articles:
|
|
 |
|
  M. Taniguchi, T. Tashiro, N. Dashtsoodol, N. Hongo, and H. Watarai The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy Int. Immunol., October 27, 2009; (2009) dxp104v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Wallace, M. A. Marshall, S. I. Ramos, J. A. Lannigan, J. J. Field, R. M. Strieter, and J. Linden NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-{gamma} and CXCR3 chemokines Blood, July 16, 2009; 114(3): 667 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ito, K. Ando, T. Ishikawa, K. Saito, M. Takemura, M. Imawari, H. Moriwaki, and M. Seishima Role of TNF-{alpha} Produced by Nonantigen-Specific Cells in a Fulminant Hepatitis Mouse Model J. Immunol., January 1, 2009; 182(1): 391 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Germanov, L. Veinotte, R. Cullen, E. Chamberlain, E. C. Butcher, and B. Johnston Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-Restricted NKT Cells J. Immunol., July 1, 2008; 181(1): 81 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Biburger and G. Tiegs Activation-induced NKT cell hyporesponsiveness protects from {alpha}-galactosylceramide hepatitis and is independent of active transregulatory factors J. Leukoc. Biol., July 1, 2008; 84(1): 264 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Stevenson, E. C. Crossley, N. Thirumalapura, D. H. Walker, and N. Ismail Regulatory Roles of CD1d-Restricted NKT Cells in the Induction of Toxic Shock-Like Syndrome in an Animal Model of Fatal Ehrlichiosis Infect. Immun., April 1, 2008; 76(4): 1434 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimaoka, K.-i. Seino, N. Kume, M. Minami, C. Nishime, M. Suematsu, T. Kita, M. Taniguchi, K. Matsushima, and S. Yonehara Critical Role for CXC Chemokine Ligand 16 (SR-PSOX) in Th1 Response Mediated by NKT Cells J. Immunol., December 15, 2007; 179(12): 8172 - 8179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Soulard, J. Roland, C. Sellier, A. C. Gruner, M. Leite-de-Moraes, J.-F. Franetich, L. Renia, P.-A. Cazenave, and S. Pied Primary Infection of C57BL/6 Mice with Plasmodium yoelii Induces a Heterogeneous Response of NKT Cells Infect. Immun., May 1, 2007; 75(5): 2511 - 2522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhu, S. Diem, L. M. Araujo, A. Aumeunier, J. Denizeau, E. Philadelphe, D. Damotte, M. Samson, P. Gourdy, M. Dy, et al. The Pro-Th1 Cytokine IL-12 Enhances IL-4 Production by Invariant NKT Cells: Relevance for T Cell-Mediated Hepatitis J. Immunol., May 1, 2007; 178(9): 5435 - 5442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wahl, P. Bochtler, R. Schirmbeck, and J. Reimann Type I IFN-Producing CD4 V{alpha}14i NKT Cells Facilitate Priming of IL-10-Producing CD8 T Cells by Hepatocytes J. Immunol., February 15, 2007; 178(4): 2083 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bochtler, C. Wahl, R. Schirmbeck, and J. Reimann Functional Adaptive CD4 Foxp3 T Cells Develop in MHC Class II-Deficient Mice J. Immunol., December 15, 2006; 177(12): 8307 - 8314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Joshi, J.-Q. Liu, Y. Wang, X. Chang, J. Richards, E. Assarsson, F.-D. Shi, H.-G. Ljunggren, and X.-F. Bai Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms J. Leukoc. Biol., December 1, 2006; 80(6): 1345 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Campos, M. Szczepanik, M. Lisbonne, A. Itakura, M. Leite-de-Moraes, and P. W. Askenase Invariant NKT Cells Rapidly Activated via Immunization with Diverse Contact Antigens Collaborate In Vitro with B-1 Cells to Initiate Contact Sensitivity J. Immunol., September 15, 2006; 177(6): 3686 - 3694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bertoletti and A. J. Gehring The immune response during hepatitis B virus infection J. Gen. Virol., June 1, 2006; 87(6): 1439 - 1449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Svensson, S. Zubairi, A. Maroof, F. Kazi, M. Taniguchi, and P. M. Kaye Invariant NKT Cells Are Essential for the Regulation of Hepatic CXCL10 Gene Expression during Leishmania donovani Infection Infect. Immun., November 1, 2005; 73(11): 7541 - 7547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Biburger and G. Tiegs {alpha}-Galactosylceramide-Induced Liver Injury in Mice Is Mediated by TNF-{alpha} but Independent of Kupffer Cells J. Immunol., August 1, 2005; 175(3): 1540 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Duthie and S. J. Kahn NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection Int. Immunol., May 1, 2005; 17(5): 607 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Duthie, M. Kahn, M. White, R. P. Kapur, and S. J. Kahn Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection Infect. Immun., March 1, 2005; 73(3): 1890 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lin, T. J. Roberts, P. M. Spence, and R. R. Brutkiewicz Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection J. Leukoc. Biol., February 1, 2005; 77(2): 151 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schmieg, G. Yang, R. W. Franck, N. Van Rooijen, and M. Tsuji Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion PNAS, January 25, 2005; 102(4): 1127 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Kirby, M. Sundquist, and M. J. Wick In Vivo Compartmentalization of Functionally Distinct, Rapidly Responsive Antigen-Specific T-Cell Populations in DNA-Immunized or Salmonella enterica Serovar Typhimurium-Infected Mice Infect. Immun., November 1, 2004; 72(11): 6390 - 6400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Johansson and M. J. Wick Liver Dendritic Cells Present Bacterial Antigens and Produce Cytokines upon Salmonella Encounter J. Immunol., February 15, 2004; 172(4): 2496 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Lin, P.-Y. Shu, C. Chang, A.-K. Ng, and C.-p. Hu IL-4 Suppresses the Expression and the Replication of Hepatitis B Virus in the Hepatocellular Carcinoma Cell Line Hep3B J. Immunol., November 1, 2003; 171(9): 4708 - 4716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Moore, M. L. Perry, A. G. Getsoian, C. L. Monteleon, A. L. Cogen, and T. J. Standiford Increased Mortality and Dysregulated Cytokine Production in Tumor Necrosis Factor Receptor 1-Deficient Mice following Systemic Klebsiella pneumoniae Infection Infect. Immun., September 1, 2003; 71(9): 4891 - 4900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-X. Lian, T. Okada, X.-S. He, H. Kita, Y.-J. Liu, A. A. Ansari, K. Kikuchi, S. Ikehara, and M. E. Gershwin Heterogeneity of Dendritic Cells in the Mouse Liver: Identification and Characterization of Four Distinct Populations J. Immunol., March 1, 2003; 170(5): 2323 - 2330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Stober, I. Jomantaite, R. Schirmbeck, and J. Reimann NKT Cells Provide Help for Dendritic Cell-Dependent Priming of MHC Class I-Restricted CD8+ T Cells In Vivo J. Immunol., March 1, 2003; 170(5): 2540 - 2548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Yoo and S. Desiderio Innate and acquired immunity intersect in a global view of the acute-phase response PNAS, February 4, 2003; 100(3): 1157 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Trobonjaca, A. Kroger, D. Stober, F. Leithauser, P. Moller, H. Hauser, R. Schirmbeck, and J. Reimann Activating Immunity in the Liver. II. IFN-{beta} Attenuates NK Cell-Dependent Liver Injury Triggered by Liver NKT Cell Activation J. Immunol., April 15, 2002; 168(8): 3763 - 3770. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
