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Cutting Edge |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
CD4+CD25+ regulatory T cells inhibit
organ-specific autoimmune diseases induced by
CD4+CD25- T cells and are potent suppressors
of CD4+CD25- T cell activation in vitro. We
demonstrate that CD4+CD25+ T cells also
suppress both proliferation and IFN-
production by CD8+
T cells induced either by polyclonal or Ag-specific stimuli.
CD4+CD25+ T cells inhibit the activation of
CD8+ responders by inhibiting both IL-2 production and
up-regulation of IL-2R
-chain (CD25) expression. Suppression is
mediated via a T-T interaction as activated
CD4+CD25+ T cells suppress the responses of
TCR-transgenic CD8+ T cells stimulated with soluble
peptide-MHC class I tetramers in the complete absence of APC. These
results broaden the immunoregulatory role played by
CD4+CD25+ T cells in the prevention of
autoimmune diseases, but also raise the possibility that they may
hinder the induction of effector CD8+ T cells to tumor or
foreign Ags.
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