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Cutting Edge |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
CD4+CD25+ regulatory T cells inhibit
organ-specific autoimmune diseases induced by
CD4+CD25- T cells and are potent suppressors
of CD4+CD25- T cell activation in vitro. We
demonstrate that CD4+CD25+ T cells also
suppress both proliferation and IFN-
production by CD8+
T cells induced either by polyclonal or Ag-specific stimuli.
CD4+CD25+ T cells inhibit the activation of
CD8+ responders by inhibiting both IL-2 production and
up-regulation of IL-2R
-chain (CD25) expression. Suppression is
mediated via a T-T interaction as activated
CD4+CD25+ T cells suppress the responses of
TCR-transgenic CD8+ T cells stimulated with soluble
peptide-MHC class I tetramers in the complete absence of APC. These
results broaden the immunoregulatory role played by
CD4+CD25+ T cells in the prevention of
autoimmune diseases, but also raise the possibility that they may
hinder the induction of effector CD8+ T cells to tumor or
foreign Ags.
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 D. Lundsgaard, T. L. Holm, L. Hornum, and H. Markholst In Vivo Control of Diabetogenic T-Cells by Regulatory CD4+CD25+ T-Cells Expressing Foxp3 Diabetes, April 1, 2005; 54(4): 1040 - 1047. [Abstract] [Full Text] [PDF]
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O. Franzese, P. T. F. Kennedy, A. J. Gehring, J. Gotto, R. Williams, M. K. Maini, and A. Bertoletti Modulation of the CD8+-T-Cell Response by CD4+ CD25+ Regulatory T Cells in Patients with Hepatitis B Virus Infection J. Virol., March 15, 2005; 79(6): 3322 - 3328. [Abstract] [Full Text] [PDF]
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L. A. Ormandy, T. Hillemann, H. Wedemeyer, M. P. Manns, T. F. Greten, and F. Korangy Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma Cancer Res., March 15, 2005; 65(6): 2457 - 2464. [Abstract] [Full Text] [PDF]
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P. Zhou, S. J. Balin, M. Mashayekhi, K. W. Hwang, D. A. Palucki, and M.-L. Alegre Transplantation Tolerance in NF-{kappa}B-Impaired Mice Is Not Due to Regulation but Is Prevented by Transgenic Expression of Bcl-xL J. Immunol., March 15, 2005; 174(6): 3447 - 3453. [Abstract] [Full Text] [PDF]
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P. A. Antony, C. A. Piccirillo, A. Akpinarli, S. E. Finkelstein, P. J. Speiss, D. R. Surman, D. C. Palmer, C.-C. Chan, C. A. Klebanoff, W. W. Overwijk, et al. CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells J. Immunol., March 1, 2005; 174(5): 2591 - 2601. [Abstract] [Full Text] [PDF]
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T. Alvaro, M. Lejeune, M. T. Salvado, R. Bosch, J. F. Garcia, J. Jaen, A. H. Banham, G. Roncador, C. Montalban, and M. A. Piris Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells Clin. Cancer Res., February 15, 2005; 11(4): 1467 - 1473. [Abstract] [Full Text] [PDF]
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P. E. Rao, A. L. Petrone, and P. D. Ponath Differentiation and Expansion of T Cells with Regulatory Function from Human Peripheral Lymphocytes by Stimulation in the Presence of TGF-{beta} J. Immunol., February 1, 2005; 174(3): 1446 - 1455. [Abstract] [Full Text] [PDF]
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M.-L. Chen, M. J. Pittet, L. Gorelik, R. A. Flavell, R. Weissleder, H. von Boehmer, and K. Khazaie Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo PNAS, January 11, 2005; 102(2): 419 - 424. [Abstract] [Full Text] [PDF]
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S. Lindley, C. M. Dayan, A. Bishop, B. O. Roep, M. Peakman, and T. I.M. Tree Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes Diabetes, January 1, 2005; 54(1): 92 - 99. [Abstract] [Full Text] [PDF]
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L. Weiss, V. Donkova-Petrini, L. Caccavelli, M. Balbo, C. Carbonneil, and Y. Levy Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients Blood, November 15, 2004; 104(10): 3249 - 3256. [Abstract] [Full Text] [PDF]
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E. Belnoue, C. Guettier, M. Kayibanda, S. Le Rond, A.-M. Crain-Denoyelle, C. Marchiol, M. Ziol, D. Fradelizi, L. Renia, and M. Viguier Regression of Established Liver Tumor Induced by Monoepitopic Peptide-Based Immunotherapy J. Immunol., October 15, 2004; 173(8): 4882 - 4888. [Abstract] [Full Text] [PDF]
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G. L. Stephens, R. S. McHugh, M. J. Whitters, D. A. Young, D. Luxenberg, B. M. Carreno, M. Collins, and E. M. Shevach Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells J. Immunol., October 15, 2004; 173(8): 5008 - 5020. [Abstract] [Full Text] [PDF]
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Z. Liu and L. Lefrancois Intestinal Epithelial Antigen Induces Mucosal CD8 T Cell Tolerance, Activation, and Inflammatory Response J. Immunol., October 1, 2004; 173(7): 4324 - 4330. [Abstract] [Full Text] [PDF]
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A. L. Kinter, M. Hennessey, A. Bell, S. Kern, Y. Lin, M. Daucher, M. Planta, M. McGlaughlin, R. Jackson, S. F. Ziegler, et al. CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status J. Exp. Med., August 2, 2004; 200(3): 331 - 343. [Abstract] [Full Text] [PDF]
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 P. W Denton, C. M Tello, and R. W Melvold CD8 + T cells reduce in vitro interferon-g production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model Multiple Sclerosis, August 1, 2004; 10(4): 370 - 375. [Abstract] [PDF]
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E. A. Wohlfert, M. K. Callahan, and R. B. Clark Resistance to CD4+CD25+ Regulatory T Cells and TGF-{beta} in Cbl-b-/- Mice J. Immunol., July 15, 2004; 173(2): 1059 - 1065. [Abstract] [Full Text] [PDF]
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 P. M. Stuart, B. Summers, J. E. Morris, L. A. Morrison, and D. A. Leib CD8+ T cells control corneal disease following ocular infection with herpes simplex virus type 1 J. Gen. Virol., July 1, 2004; 85(7): 2055 - 2063. [Abstract] [Full Text] [PDF]
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M. Stassen, H. Jonuleit, C. Muller, M. Klein, C. Richter, T. Bopp, S. Schmitt, and E. Schmitt Differential Regulatory Capacity of CD25+ T Regulatory Cells and Preactivated CD25+ T Regulatory Cells on Development, Functional Activation, and Proliferation of Th2 Cells J. Immunol., July 1, 2004; 173(1): 267 - 274. [Abstract] [Full Text] [PDF]
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S. Vigouroux, E. Yvon, E. Biagi, and M. K. Brenner Antigen-induced regulatory T cells Blood, July 1, 2004; 104(1): 26 - 33. [Abstract] [Full Text] [PDF]
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M. Mamura, W. Lee, T. J. Sullivan, A. Felici, A. L. Sowers, J. P. Allison, and J. J. Letterio CD28 disruption exacerbates inflammation in Tgf-{beta}1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-{beta}1 Blood, June 15, 2004; 103(12): 4594 - 4601. [Abstract] [Full Text] [PDF]
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 T. L. Sumpter and D. S. Wilkes Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1129 - L1139. [Abstract] [Full Text] [PDF]
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M. A. Lyman, S. Aung, J. A. Biggs, and L. A. Sherman A Spontaneously Arising Pancreatic Tumor Does Not Promote the Differentiation of Naive CD8+ T Lymphocytes into Effector CTL J. Immunol., June 1, 2004; 172(11): 6558 - 6567. [Abstract] [Full Text] [PDF]
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B. K. Choi, J. S. Bae, E. M. Choi, W. J. Kang, S. Sakaguchi, D. S. Vinay, and B. S. Kwon 4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells J. Leukoc. Biol., May 1, 2004; 75(5): 785 - 791. [Abstract] [Full Text] [PDF]
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S. Suvas, A. K. Azkur, B. S. Kim, U. Kumaraguru, and B. T. Rouse CD4+CD25+ Regulatory T Cells Control the Severity of Viral Immunoinflammatory Lesions J. Immunol., April 1, 2004; 172(7): 4123 - 4132. [Abstract] [Full Text] [PDF]
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 S. M. Blois, C. D. Alba Soto, M. Tometten, B. F. Klapp, R. A. Margni, and P. C. Arck Lineage, Maturity, and Phenotype of Uterine Murine Dendritic Cells Throughout Gestation Indicate a Protective Role in Maintaining Pregnancy Biol Reprod, April 1, 2004; 70(4): 1018 - 1023. [Abstract] [Full Text] [PDF]
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Z. Jaffar, T. Sivakuru, and K. Roberts CD4+CD25+ T Cells Regulate Airway Eosinophilic Inflammation by Modulating the Th2 Cell Phenotype J. Immunol., March 15, 2004; 172(6): 3842 - 3849. [Abstract] [Full Text] [PDF]
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M. Hesse, C. A. Piccirillo, Y. Belkaid, J. Prufer, M. Mentink-Kane, M. Leusink, A. W. Cheever, E. M. Shevach, and T. A. Wynn The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells J. Immunol., March 1, 2004; 172(5): 3157 - 3166. [Abstract] [Full Text] [PDF]
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S. G. Zheng, J. H. Wang, M. N. Koss, F. Quismorio Jr., J. D. Gray, and D. A. Horwitz CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-{beta} Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome J. Immunol., February 1, 2004; 172(3): 1531 - 1539. [Abstract] [Full Text] [PDF]
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