The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Umemura, M.
Right arrow Articles by Yoshikai, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Umemura, M.
Right arrow Articles by Yoshikai, Y.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Medline Plus Health Information
*Tuberculosis
The Journal of Immunology, 2001, 167: 946-956.
Copyright © 2001 by The American Association of Immunologists

Overexpression of IL-15 In Vivo Enhances Protection Against Mycobacterium bovis Bacillus Calmette-Guérin Infection Via Augmentation of NK and T Cytotoxic 1 Responses1

Masayuki Umemura*, Hitoshi Nishimura*, Kenji Hirose{dagger}, Tetsuya Matsuguchi* and Yasunobu Yoshikai2,*

* Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan; and {dagger} Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan

To investigate the immunomodulating effects of IL-15 in vivo on mycobacterial infection, we used IL-15-transgenic (Tg) mice, which were recently constructed with cDNA-encoding secretable isoform of IL-15 precursor protein under the control of a MHC class I promoter. The IL-15-Tg mice exhibited resistance against infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG), as assessed by bacteria growth. IFN-{gamma} level in serum was significantly higher in IL-15-Tg mice than in non-Tg mice after BCG infection. NK cells were remarkably increased, and Ag-specific T cytotoxic 1 response mediated by CD8+ T cells producing IFN-{gamma} was significantly augmented in the IL-15-Tg mice following BCG infection. Neutralization of endogenous IFN-{gamma} by in vivo administration of anti-IFN-{gamma} mAb deteriorated the clearance of the bacteria. Depletion of of NK cells or CD8+ T cells by invivo administration of anti-asialo-GM1 Ab or anti-CD8 mAb hampered the exclusion of bacteria. Thus, overexpression of IL-15 in vivo enhanced protection against BCG infection via augmentation of NK and T cytotoxic 1 responses.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
R. Dhiman, M. Indramohan, P. F. Barnes, R. C. Nayak, P. Paidipally, L. V. M. Rao, and R. Vankayalapati
IL-22 Produced by Human NK Cells Inhibits Growth of Mycobacterium tuberculosis by Enhancing Phagolysosomal Fusion
J. Immunol., November 15, 2009; 183(10): 6639 - 6645.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Paidipally, S. Periasamy, P. F. Barnes, R. Dhiman, M. Indramohan, D. E. Griffith, D. Cosman, and R. Vankayalapati
NKG2D-Dependent IL-17 Production by Human T Cells in Response to an Intracellular Pathogen
J. Immunol., August 1, 2009; 183(3): 1940 - 1945.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. Tang, H. Yamada, K. Shibata, S.-i. Yoshida, W. Wajjwalku, and Y. Yoshikai
IL-15 protects antigen-specific CD8+ T cell contraction after Mycobacterium bovis bacillus Calmette-Guerin infection
J. Leukoc. Biol., July 1, 2009; 86(1): 187 - 194.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
N. Gill and A. A. Ashkar
Overexpression of Interleukin-15 Compromises CD4-Dependent Adaptive Immune Responses against Herpes Simplex Virus 2
J. Virol., January 15, 2009; 83(2): 918 - 926.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. A. Ashkar, S. Reid, E. F. Verdu, K. Zhang, and B. K. Coombes
Interleukin-15 and NK1.1+ Cells Provide Innate Protection against Acute Salmonella enterica Serovar Typhimurium Infection in the Gut and in Systemic Tissues
Infect. Immun., January 1, 2009; 77(1): 214 - 222.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. R. Krutzik, M. Hewison, P. T. Liu, J. A. Robles, S. Stenger, J. S. Adams, and R. L. Modlin
IL-15 Links TLR2/1-Induced Macrophage Differentiation to the Vitamin D-Dependent Antimicrobial Pathway
J. Immunol., November 15, 2008; 181(10): 7115 - 7120.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Dudani, K. Murali-Krishna, L. Krishnan, and S. Sad
IFN-{gamma} Induces the Erosion of Preexisting CD8 T Cell Memory during Infection with a Heterologous Intracellular Bacterium
J. Immunol., August 1, 2008; 181(3): 1700 - 1709.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-L. Small, S. McCormick, N. Gill, K. Kugathasan, M. Santosuosso, N. Donaldson, D. E. Heinrichs, A. Ashkar, and Z. Xing
NK Cells Play a Critical Protective Role in Host Defense against Acute Extracellular Staphylococcus aureus Bacterial Infection in the Lung
J. Immunol., April 15, 2008; 180(8): 5558 - 5568.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
Y. Kagimoto, H. Yamada, T. Ishikawa, N. Maeda, F. Goshima, Y. Nishiyama, M. Furue, and Y. Yoshikai
A regulatory role of interleukin 15 in wound healing and mucosal infection in mice
J. Leukoc. Biol., January 1, 2008; 83(1): 165 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Q. Wu, R. J. Martin, J. G. Rino, S. Jeyaseelan, R. Breed, and H. W. Chu
A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1064 - L1072.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. G. Feng, M. Kaviratne, A. G. Rothfuchs, A. Cheever, S. Hieny, H. A. Young, T. A. Wynn, and A. Sher
NK Cell-Derived IFN-{gamma} Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis
J. Immunol., November 15, 2006; 177(10): 7086 - 7093.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. A. Stoklasek, K. S. Schluns, and L. Lefrancois
Combined IL-15/IL-15R{alpha} Immunotherapy Maximizes IL-15 Activity In Vivo
J. Immunol., November 1, 2006; 177(9): 6072 - 6080.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Cruz, S. A. Khader, E. Torrado, A. Fraga, J. E. Pearl, J. Pedrosa, A. M. Cooper, and A. G. Castro
Cutting Edge: IFN-{gamma} Regulates the Induction and Expansion of IL-17-Producing CD4 T Cells during Mycobacterial Infection
J. Immunol., August 1, 2006; 177(3): 1416 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Fricke, D. Mitchell, J. Mittelstadt, N. Lehan, H. Heine, T. Goldmann, A. Bohle, and S. Brandau
Mycobacteria Induce IFN-{gamma} Production in Human Dendritic Cells via Triggering of TLR2
J. Immunol., May 1, 2006; 176(9): 5173 - 5182.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Saito, T. Yajima, S. Kumabe, T. Doi, H. Yamada, S. Sad, H. Shen, and Y. Yoshikai
Impaired Protection against Mycobacterium bovis Bacillus Calmette-Guerin Infection in IL-15-Deficient Mice
J. Immunol., February 15, 2006; 176(4): 2496 - 2504.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Lazarevic, D. J. Yankura, S. J. Divito, and J. L. Flynn
Induction of Mycobacterium tuberculosis-Specific Primary and Secondary T-Cell Responses in Interleukin-15-Deficient Mice
Infect. Immun., May 1, 2005; 73(5): 2910 - 2922.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Ing, P. Gros, and M. M. Stevenson
Interleukin-15 Enhances Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection in Mice
Infect. Immun., May 1, 2005; 73(5): 3172 - 3177.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
O. Alpdogan, J. M. Eng, S. J. Muriglan, L. M. Willis, V. M. Hubbard, K. H. Tjoe, T. H. Terwey, A. Kochman, and M. R. M. van den Brink
Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation
Blood, January 15, 2005; 105(2): 865 - 873.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. W. Blaser, S. Roychowdhury, D. J. Kim, N. R. Schwind, D. Bhatt, W. Yuan, D. F. Kusewitt, A. K. Ferketich, M. A. Caligiuri, and M. Guimond
Donor-derived IL-15 is critical for acute allogeneic graft-versus-host disease
Blood, January 15, 2005; 105(2): 894 - 901.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Yajima, H. Nishimura, K. Saito, H. Kuwano, and Y. Yoshikai
Overexpression of Interleukin-15 Increases Susceptibility to Lipopolysaccharide-Induced Liver Injury in Mice Primed with Mycobacterium bovis Bacillus Calmette-Guerin
Infect. Immun., July 1, 2004; 72(7): 3855 - 3862.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Chapdelaine, D. K. Smith, J. A. Pedras-Vasconcelos, L. Krishnan, and S. Sad
Increased CD8+ T Cell Memory to Concurrent Infection at the Expense of Increased Erosion of Pre-existing Memory: The Paradoxical Role of IL-15
J. Immunol., November 15, 2003; 171(10): 5454 - 5460.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Umemura, H. Nishimura, K. Saito, T. Yajima, G. Matsuzaki, S. Mizuno, I. Sugawara, and Y. Yoshikai
Interleukin-15 as an Immune Adjuvant To Increase the Efficacy of Mycobacterium bovis Bacillus Calmette-Guerin Vaccination
Infect. Immun., October 1, 2003; 71(10): 6045 - 6048.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. E. Toliver-Kinsky, C. Y. Lin, D. N. Herndon, and E. R. Sherwood
Stimulation of Hematopoiesis by the Fms-Like Tyrosine Kinase 3 Ligand Restores Bacterial Induction of Th1 Cytokines in Thermally Injured Mice
Infect. Immun., June 1, 2003; 71(6): 3058 - 3067.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Oh, J. A. Berzofsky, D. S. Burke, T. A. Waldmann, and L. P. Perera
Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity
PNAS, March 18, 2003; 100(6): 3392 - 3397.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. UMEMURA, H. NISHIMURA, T. YAJIMA, W. WAJJWALK, T. MATSUGUCHI, M. TAKAHASHI, Y. NISHIYAMA, M. MAKINO, Y. NAGAI, and Y. YOSHIKAI
Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome
FASEB J, November 1, 2002; 16(13): 1755 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Hermann, C. Truyens, C. Alonso-Vega, J. Even, P. Rodriguez, A. Berthe, E. Gonzalez-Merino, F. Torrico, and Y. Carlier
Human fetuses are able to mount an adultlike CD8 T-cell response
Blood, August 28, 2002; 100(6): 2153 - 2158.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Yajima, H. Nishimura, R. Ishimitsu, T. Watase, D. H. Busch, E. G. Pamer, H. Kuwano, and Y. Yoshikai
Overexpression of IL-15 In Vivo Increases Antigen-Driven Memory CD8+ T Cells Following a Microbe Exposure
J. Immunol., February 1, 2002; 168(3): 1198 - 1203.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.