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Receptors in Antibody-Dependent Corneal Inflammation1
Departments of Medicine and Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106
Although production of specific Ab is a critical element of host
defense, the presence of Ab in tissues leads to formation of immune
complexes, which can trigger a type III Arthus reaction. Our studies on
a mouse model of river blindness showed that Ab production is essential
for recruitment of neutrophils and eosinophils to the cornea and for
development of corneal opacification. In the current study, we
determined the relative contribution of complement and Fc
R
interactions in triggering immune complex-mediated corneal disease.
FcR-/- mice, C3-/- mice, and
immunocompetent control (B6/129Sj) mice were immunized s.c. and
injected intrastromally with Onchocerca volvulus Ags.
Slit lamp examination showed that control mice, C3-/-
mice, and control mice injected with cobra venom factor developed
pronounced corneal opacification, whereas corneas of
FcR-/- mice remained completely clear. Furthermore,
recruitment of neutrophils and eosinophils to the corneal stroma was
significantly impaired in FcR-/- mice, but not in
C3-/- mice or cobra venom factor-treated mice. We
therefore conclude that FcR-mediated cell activation, rather than
complement activation, is the dominant pathway of immune complex
disease in the cornea. These findings demonstrate a novel role for
FcR interactions in mediating ocular
inflammation.
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