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Response During T Cell Activation Is Modulated by IL-101
Institut National de la Santé et de la Recherche Médicale, Unité 343, Nice, France
TGF-
1 is an important pleiotropic cytokine that has been
described to have both stimulatory and inhibitory effects on cell
growth and differentiation. For several cell types, the effect of
TGF-1 was found to correlate with the differentiation stage of the
cells and the presence of other cytokines. In this report, we address
the influence of TGF-1 on CD4+ T cell activation by
evaluating the effect of TGF-1 on the proliferative and cytokine
responses of purified resting and activated human or mouse
CD4+ T cells. TGF-1 inhibits proliferation and cytokine
secretion on resting CD4+ T cells but has no inhibitory
effect on activated T cells. Moreover, TGF-1 unresponsiveness of
activated T cells was correlated with a down-regulation in the
expression of the TGF- receptor type II. Interestingly, IL-10
addition enhances TGF- receptor type II expression and restores
TGF- responsiveness on activated T cells. These results indicated
that TGF- responsiveness is sequentially regulated on T cells by the
modulation of the of TGF- receptor type II chain expression.
Moreover, we have identified a novel regulatory role of IL-10 on
TGF--dependent T cell growth that can explain the control of T cell
activation on chronic vs acute inflammatory sites.
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