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*
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;
Scripps Clinic and Research Foundation, La Jolla, CA 92037;
Joslin Diabetes Center, Boston, MA 02215;
Oklahoma State University, Stillwater, OK 74078;
¶ Laboratory for Immunological Research, Schering-Plough, Dardilly France
The dendritic cells (DC) of mouse lymph nodes (LN) were isolated, analyzed for surface markers, and compared with those of spleen. Low to moderate staining of LN DC for CD4 and low staining for CD8 was shown to be attributable to pickup of these markers from T cells. Excluding this artifact, five LN DC subsets could be delineated. They included the three populations found in spleen (CD4+8-DEC-205-, CD4-8-DEC-205-, CD4-8+DEC-205+), although the CD4-expressing DC were of low incidence. LN DC included two additional populations, characterized by relatively low expression of CD8 but moderate or high expression of DEC-205. Both appeared among the DC migrating out of skin into LN, but only one was restricted to skin-draining LN and was identified as the mature form of epidermal Langerhans cells (LC). The putative LC-derived DC displayed the following properties: large size; high levels of class II MHC, which persisted to some extent even in CIITA null mice; expression of very high levels of DEC-205 and of CD40; expression of many myeloid surface markers; and no expression of CD4 and only low to moderate expression of CD8. The putative LC-derived DC among skin emigrants and in LN also showed strong intracellular staining of langerin.
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A. D. Edwards, D. Chaussabel, S. Tomlinson, O. Schulz, A. Sher, and C. Reis e Sousa Relationships Among Murine CD11chigh Dendritic Cell Subsets as Revealed by Baseline Gene Expression Patterns J. Immunol., July 1, 2003; 171(1): 47 - 60. [Abstract] [Full Text] [PDF]
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G. Lugo-Villarino, R. Maldonado-Lopez, R. Possemato, C. Penaranda, and L. H. Glimcher T-bet is required for optimal production of IFN-{gamma} and antigen-specific T cell activation by dendritic cells PNAS, June 24, 2003; 100(13): 7749 - 7754. [Abstract] [Full Text] [PDF]
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K. G. Hogg, S. Kumkate, S. Anderson, and A. P. Mountford Interleukin-12 p40 Secretion by Cutaneous CD11c+ and F4/80+ Cells Is a Major Feature of the Innate Immune Response in Mice That Develop Th1-Mediated Protective Immunity to Schistosomamansoni Infect. Immun., June 1, 2003; 71(6): 3563 - 3571. [Abstract] [Full Text] [PDF]
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M. Yoshino, H. Yamazaki, H. Nakano, T. Kakiuchi, K. Ryoke, T. Kunisada, and S.-I. Hayashi Distinct antigen trafficking from skin in the steady and active states Int. Immunol., June 1, 2003; 15(6): 773 - 779. [Abstract] [Full Text] [PDF]
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L. Corcoran, I. Ferrero, D. Vremec, K. Lucas, J. Waithman, M. O'Keeffe, L. Wu, A. Wilson, and K. Shortman The Lymphoid Past of Mouse Plasmacytoid Cells and Thymic Dendritic Cells J. Immunol., May 15, 2003; 170(10): 4926 - 4932. [Abstract] [Full Text] [PDF]
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E. Muraille, C. De Trez, B. Pajak, F. A. Torrentera, P. De Baetselier, O. Leo, and Y. Carlier Amastigote Load and Cell Surface Phenotype of Infected Cells from Lesions and Lymph Nodes of Susceptible and Resistant Mice Infected with Leishmania major Infect. Immun., May 1, 2003; 71(5): 2704 - 2715. [Abstract] [Full Text] [PDF]
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C. M. Smith, G. T. Belz, N. S. Wilson, J. A. Villadangos, K. Shortman, F. R. Carbone, and W. R. Heath Cutting Edge: Conventional CD8{alpha}+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1 J. Immunol., May 1, 2003; 170(9): 4437 - 4440. [Abstract] [Full Text] [PDF]
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J. Alferink, I. Lieberam, W. Reindl, A. Behrens, S. Weiss, N. Huser, K. Gerauer, R. Ross, A. B. Reske-Kunz, P. Ahmad-Nejad, et al. Compartmentalized Production of CCL17 In Vivo: Strong Inducibility in Peripheral Dendritic Cells Contrasts Selective Absence from the Spleen J. Exp. Med., March 3, 2003; 197(5): 585 - 599. [Abstract] [Full Text] [PDF]
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Z.-X. Lian, T. Okada, X.-S. He, H. Kita, Y.-J. Liu, A. A. Ansari, K. Kikuchi, S. Ikehara, and M. E. Gershwin Heterogeneity of Dendritic Cells in the Mouse Liver: Identification and Characterization of Four Distinct Populations J. Immunol., March 1, 2003; 170(5): 2323 - 2330. [Abstract] [Full Text] [PDF]
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P. S. Tan, A. L. Gavin, N. Barnes, D. W. Sears, D. Vremec, K. Shortman, S. Amigorena, P. L. Mottram, and P. M. Hogarth Unique Monoclonal Antibodies Define Expression of Fc{gamma}RI on Macrophages and Mast Cell Lines and Demonstrate Heterogeneity Among Subcutaneous and Other Dendritic Cells J. Immunol., March 1, 2003; 170(5): 2549 - 2556. [Abstract] [Full Text] [PDF]
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M. O'Keeffe, H. Hochrein, D. Vremec, B. Scott, P. Hertzog, L. Tatarczuch, and K. Shortman Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors Blood, February 15, 2003; 101(4): 1453 - 1459. [Abstract] [Full Text] [PDF]
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X. Zhao, E. Deak, K. Soderberg, M. Linehan, D. Spezzano, J. Zhu, D. M. Knipe, and A. Iwasaki Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2 J. Exp. Med., January 20, 2003; 197(2): 153 - 162. [Abstract] [Full Text] [PDF]
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M. O'Keeffe, H. Hochrein, D. Vremec, I. Caminschi, J. L. Miller, E. M. Anders, L. Wu, M. H. Lahoud, S. Henri, B. Scott, et al. Mouse Plasmacytoid Cells: Long-lived Cells, Heterogeneous in Surface Phenotype and Function, that Differentiate Into CD8+ Dendritic Cells Only after Microbial Stimulus J. Exp. Med., November 18, 2002; 196(10): 1307 - 1319. [Abstract] [Full Text] [PDF]
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G. T. Belz, G. M.N. Behrens, C. M. Smith, J. F.A.P. Miller, C. Jones, K. Lejon, C. G. Fathman, S. N. Mueller, K. Shortman, F. R. Carbone, et al. The CD8{alpha}+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens J. Exp. Med., October 21, 2002; 196(8): 1099 - 1104. [Abstract] [Full Text] [PDF]
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J. M.M. den Haan and M. J. Bevan Constitutive versus Activation-dependent Cross-Presentation of Immune Complexes by CD8+ and CD8- Dendritic Cells In Vivo J. Exp. Med., September 16, 2002; 196(6): 817 - 827. [Abstract] [Full Text] [PDF]
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A. Nopora and T. Brocker Bcl-2 Controls Dendritic Cell Longevity In Vivo J. Immunol., September 15, 2002; 169(6): 3006 - 3014. [Abstract] [Full Text] [PDF]
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 X. Zhang, L. M. Hillyer, and B. D. Woodward The Capacity of Noninflammatory (Steady-State) Dendritic Cells to Present Antigen in the Primary Response Is Preserved in Acutely Protein- or Energy-Deficient Weanling Mice J. Nutr., September 1, 2002; 132(9): 2748 - 2756. [Abstract] [Full Text] [PDF]
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A. T. Kamath, S. Henri, F. Battye, D. F. Tough, and K. Shortman Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs Blood, August 13, 2002; 100(5): 1734 - 1741. [Abstract] [Full Text] [PDF]
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S. Henri, J. Curtis, H. Hochrein, D. Vremec, K. Shortman, and E. Handman Hierarchy of Susceptibility of Dendritic Cell Subsets to Infection by Leishmania major: Inverse Relationship to Interleukin-12 Production Infect. Immun., July 1, 2002; 70(7): 3874 - 3880. [Abstract] [Full Text] [PDF]
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