| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
+ Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase1
*
Department of Experimental Medicine, University of Perugia, Perugia, Italy; and
Ludwig Institute for Cancer Research, Brussels, Belgium
The outcome of dendritic cell (DC) presentation of tumor and/or
self peptides, including P815AB (a tumor peptide of murine mastocytoma
cells) and NRP-A7 (a synthetic peptide mimotope recognized by
diabetogenic T cells), may depend on a balance between the activities
of immunogenic (CD8
-) and tolerogenic
(CD8+) DC. By virtue of their respective actions on
CD8- and CD8+ DC, IL-12 and IFN-
have
functionally opposing effects on peptide presentation by the
CD8- DC subset, and IFN--activated CD8+ DC
mediate tolerogenic effects that prevail over the adjuvant activity of
IL-12 on CD8- DC. We have previously shown that CD40
ligation abrogates the tolerogenic potential of CD8+ DC, an
effect associated with an impaired capacity of the CD40-modulated and
IFN--treated DC to degrade tryptophan and initiate T cell apoptosis
in vitro. We report here that IL-6 may both replace (upon
administration of the recombinant cytokine) and mediate (as assessed by
the use of neutralizing Abs) the effect of CD40 ligation in ablating
the tolerogenic activity of CD8+ DC. The activity of IL-6
includes down-regulation of IFN-R expression in the CD8+
DC subset and correlates to a reduced ability of these cells to
metabolize tryptophan and initiate T cell apoptosis in
vitro.
This article has been cited by other articles:
|
|
 |
|
  F. Qian, J. Villella, P. K. Wallace, P. Mhawech-Fauceglia, J. D. Tario Jr., C. Andrews, J. Matsuzaki, D. Valmori, M. Ayyoub, P. J. Frederick, et al. Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase-Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer Cancer Res., July 1, 2009; 69(13): 5498 - 5504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Curti, S. Trabanelli, V. Salvestrini, M. Baccarani, and R. M. Lemoli The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology Blood, March 12, 2009; 113(11): 2394 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Ganesh, D. M. Cheatem, J. R. Sheng, C. Vasu, and B. S. Prabhakar GM-CSF-induced CD11c+CD8a--dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis Int. Immunol., March 1, 2009; 21(3): 269 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-I. Jeong, S. W. Kim, I. D. Jung, J. S. Lee, J. H. Chang, C.-M. Lee, S. H. Chun, M.-S. Yoon, G. T. Kim, S. W. Ryu, et al. Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase C{delta}-STAT1 Signaling Pathway in Interferon-{gamma}-stimulated Murine Dendritic Cells J. Biol. Chem., February 6, 2009; 284(6): 3700 - 3708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Orabona, M. T. Pallotta, C. Volpi, F. Fallarino, C. Vacca, R. Bianchi, M. L. Belladonna, M. C. Fioretti, U. Grohmann, and P. Puccetti SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis PNAS, December 30, 2008; 105(52): 20828 - 20833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Muller, M. D. Sharma, P. R. Chandler, J. B. DuHadaway, M. E. Everhart, B. A. Johnson III, D. J. Kahler, J. Pihkala, A. P. Soler, D. H. Munn, et al. Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase PNAS, November 4, 2008; 105(44): 17073 - 17078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Belladonna, C. Volpi, R. Bianchi, C. Vacca, C. Orabona, M. T. Pallotta, L. Boon, S. Gizzi, M. C. Fioretti, U. Grohmann, et al. Cutting Edge: Autocrine TGF-{beta} Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells J. Immunol., October 15, 2008; 181(8): 5194 - 5198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, X. Liang, A. J. Peterson, D. H. Munn, and B. R. Blazar The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation J. Immunol., October 15, 2008; 181(8): 5396 - 5404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Romani, T. Zelante, A. De Luca, F. Fallarino, and P. Puccetti IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi J. Immunol., April 15, 2008; 180(8): 5157 - 5162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Giroux, E. Yurchenko, J. St.-Pierre, C. A. Piccirillo, and C. Perreault T Regulatory Cells Control Numbers of NK Cells and CD8{alpha}+ Immature Dendritic Cells in the Lymph Node Paracortex J. Immunol., October 1, 2007; 179(7): 4492 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M Blois, U. Kammerer, C. A. Soto, M. C Tometten, V. Shaikly, G. Barrientos, R. Jurd, D. Rukavina, A. W Thomson, B. F Klapp, et al. Dendritic Cells: Key to Fetal Tolerance? Biol Reprod, October 1, 2007; 77(4): 590 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Feunou, S. Vanwetswinkel, F. Gaudray, M. Goldman, P. Matthys, and M. Y. Braun Foxp3+CD25+ T Regulatory Cells Stimulate IFN-{gamma}-Independent CD152-Mediated Activation of Tryptophan Catabolism That Provides Dendritic Cells with Immune Regulatory Activity in Mice Unresponsive to Staphylococcal Enterotoxin B J. Immunol., July 15, 2007; 179(2): 910 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Fallas, W. Yi, N. A. Draghi, H. M. O'Rourke, and L. K. Denzin Expression Patterns of H2-O in Mouse B Cells and Dendritic Cells Correlate with Cell Function J. Immunol., February 1, 2007; 178(3): 1488 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-Y. Hou, A. J. Muller, M. D. Sharma, J. DuHadaway, T. Banerjee, M. Johnson, A. L. Mellor, G. C. Prendergast, and D. H. Munn Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses Cancer Res., January 15, 2007; 67(2): 792 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Agaugue, L. Perrin-Cocon, F. Coutant, P. Andre, and V. Lotteau 1-Methyl-Tryptophan Can Interfere with TLR Signaling in Dendritic Cells Independently of IDO Activity J. Immunol., August 15, 2006; 177(4): 2061 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Belladonna, U. Grohmann, P. Guidetti, C. Volpi, R. Bianchi, M. C. Fioretti, R. Schwarcz, F. Fallarino, and P. Puccetti Kynurenine Pathway Enzymes in Dendritic Cells Initiate Tolerogenesis in the Absence of Functional IDO J. Immunol., July 1, 2006; 177(1): 130 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Bleier, S. C. Katz, U. I. Chaudhry, V. G. Pillarisetty, T. P. Kingham III, A. B. Shah, J. R. Raab, and R. P. DeMatteo Biliary obstruction selectively expands and activates liver myeloid dendritic cells. J. Immunol., June 15, 2006; 176(12): 7189 - 7195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Orabona, P. Puccetti, C. Vacca, S. Bicciato, A. Luchini, F. Fallarino, R. Bianchi, E. Velardi, K. Perruccio, A. Velardi, et al. Toward the identification of a tolerogenic signature in IDO-competent dendritic cells Blood, April 1, 2006; 107(7): 2846 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A Wallet, P. Sen, and R. Tisch Immunoregulation of Dendritic Cells Clin. Med. Res., August 1, 2005; 3(3): 166 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Gordon, F. Li, A. Nayyar, J. Xiang, and X. Zhang CD8{alpha}+, but Not CD8{alpha}-, Dendritic Cells Tolerize Th2 Responses via Contact-Dependent and -Independent Mechanisms, and Reverse Airway Hyperresponsiveness, Th2, and Eosinophil Responses in a Mouse Model of Asthma J. Immunol., August 1, 2005; 175(3): 1516 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Orabona, M. L. Belladonna, C. Vacca, R. Bianchi, F. Fallarino, C. Volpi, S. Gizzi, M. C. Fioretti, U. Grohmann, and P. Puccetti Cutting Edge: Silencing Suppressor of Cytokine Signaling 3 Expression in Dendritic Cells Turns CD28-Ig from Immune Adjuvant to Suppressant J. Immunol., June 1, 2005; 174(11): 6582 - 6586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Tan, S. C. Beutelspacher, S.-A. Xue, Y.-H. Wang, P. Mitchell, J. C. McAlister, D. F. P. Larkin, M. O. McClure, H. J. Stauss, M. A. Ritter, et al. Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy Blood, May 15, 2005; 105(10): 3824 - 3832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Terness, J.-J. Chuang, T. Bauer, L. Jiga, and G. Opelz Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO? Blood, March 15, 2005; 105(6): 2480 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. O'Keeffe, T. C. Brodnicki, B. Fancke, D. Vremec, G. Morahan, E. Maraskovsky, R. Steptoe, L. C. Harrison, and K. Shortman Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development Int. Immunol., March 1, 2005; 17(3): 307 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Fallarino, R. Bianchi, C. Orabona, C. Vacca, M. L. Belladonna, M. C. Fioretti, D. V. Serreze, U. Grohmann, and P. Puccetti CTLA-4-Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice J. Exp. Med., October 18, 2004; 200(8): 1051 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Winsor-Hines, C. Merrill, M. O'Mahony, P. E. Rao, S. P. Cobbold, H. Waldmann, D. J. Ringler, and P. D. Ponath Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody J. Immunol., October 1, 2004; 173(7): 4715 - 4723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fallarino, C. Asselin-Paturel, C. Vacca, R. Bianchi, S. Gizzi, M. C. Fioretti, G. Trinchieri, U. Grohmann, and P. Puccetti Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement J. Immunol., September 15, 2004; 173(6): 3748 - 3754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Bleier, V. G. Pillarisetty, A. B. Shah, and R. P. DeMatteo Increased and Long-Term Generation of Dendritic Cells with Reduced Function from IL-6-Deficient Bone Marrow J. Immunol., June 15, 2004; 172(12): 7408 - 7416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Munn, M. D. Sharma, and A. L. Mellor Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells J. Immunol., April 1, 2004; 172(7): 4100 - 4110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Jackson, C.-R. Yu, R. M. Mahdi, S. Ebong, and C. E. Egwuagu Dendritic Cell Maturation Requires STAT1 and Is under Feedback Regulation by Suppressors of Cytokine Signaling J. Immunol., February 15, 2004; 172(4): 2307 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-G. Xiao, X.-C. Wu, J.-S. Yang, L.-Y. Xu, X. Liu, Y.-M. Huang, B. Bjelke, and H. Link Therapeutic potential of IFN-{gamma}-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis Int. Immunol., January 1, 2004; 16(1): 13 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Grohmann, R. Bianchi, C. Orabona, F. Fallarino, C. Vacca, A. Micheletti, M. C. Fioretti, and P. Puccetti Functional Plasticity of Dendritic Cell Subsets as Mediated by CD40 Versus B7 Activation J. Immunol., September 1, 2003; 171(5): 2581 - 2587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Mellor, B. Baban, P. Chandler, B. Marshall, K. Jhaver, A. Hansen, P. A. Koni, M. Iwashima, and D. H. Munn Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion J. Immunol., August 15, 2003; 171(4): 1652 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Grohmann, F. Fallarino, R. Bianchi, C. Orabona, C. Vacca, M. C. Fioretti, and P. Puccetti A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice J. Exp. Med., July 7, 2003; 198(1): 153 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Mellor and D. H. Munn Tryptophan Catabolism and Regulation of Adaptive Immunity J. Immunol., June 15, 2003; 170(12): 5809 - 5813. [Full Text] [PDF]
|
|
|
|
|
|
G. Miller, V. G. Pillarisetty, A. B. Shah, S. Lahrs, and R. P. DeMatteo Murine Flt3 Ligand Expands Distinct Dendritic Cells with Both Tolerogenic and Immunogenic Properties J. Immunol., April 1, 2003; 170(7): 3554 - 3564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Miller, V. G. Pillarisetty, A. B. Shah, S. Lahrs, Z. Xing, and R. P. DeMatteo Endogenous Granulocyte-Macrophage Colony-Stimulating Factor Overexpression In Vivo Results in the Long-Term Recruitment of a Distinct Dendritic Cell Population with Enhanced Immunostimulatory Function J. Immunol., September 15, 2002; 169(6): 2875 - 2885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Munn, M. D. Sharma, J. R. Lee, K. G. Jhaver, T. S. Johnson, D. B. Keskin, B. Marshall, P. Chandler, S. J. Antonia, R. Burgess, et al. Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase Science, September 13, 2002; 297(5588): 1867 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Terness, T. M. Bauer, L. Rose, C. Dufter, A. Watzlik, H. Simon, and G. Opelz Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase-expressing Dendritic Cells: Mediation of Suppression by Tryptophan Metabolites J. Exp. Med., August 19, 2002; 196(4): 447 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fallarino, U. Grohmann, C. Vacca, R. Bianchi, M. C. Fioretti, and P. Puccetti CD40 Ligand and CTLA-4 Are Reciprocally Regulated in the Th1 Cell Proliferative Response Sustained by CD8+ Dendritic Cells J. Immunol., August 1, 2002; 169(3): 1182 - 1188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Belladonna, J.-C. Renauld, R. Bianchi, C. Vacca, F. Fallarino, C. Orabona, M. C. Fioretti, U. Grohmann, and P. Puccetti IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells J. Immunol., June 1, 2002; 168(11): 5448 - 5454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mann, F. Oakley, P. W. M. Johnson, and D. A. Mann CD40 Induces Interleukin-6 Gene Transcription in Dendritic Cells. REGULATION BY TRAF2, AP-1, NF-kappa B, AND CBF1 J. Biol. Chem., May 3, 2002; 277(19): 17125 - 17138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Mellor, D. B. Keskin, T. Johnson, P. Chandler, and D. H. Munn Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses J. Immunol., April 15, 2002; 168(8): 3771 - 3776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fallarino, C. Vacca, C. Orabona, M. L. Belladonna, R. Bianchi, B. Marshall, D. B. Keskin, A. L. Mellor, M. C. Fioretti, U. Grohmann, et al. Functional expression of indoleamine 2,3-dioxygenase by murine CD8{alpha}+ dendritic cells Int. Immunol., January 1, 2002; 14(1): 65 - 68. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
