| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
*
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611; and
Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202
A role for Stat4 in IL-12-induced up-regulation of selectin
ligands on Th1 cells was explored. Th1 cells generated from
Stat4-/- mice exhibited no IL-12-inducible P-selectin
ligands, no up-regulation of core 2 
1,6-glucosaminyltransferase I
(C2GlcNAcT-I), and low levels of the Th1 transcription factor T-bet. In
contrast, Stat4-/- Th1 cells exhibited only a partial
defect in expression of IL-12-inducible E-selectin ligands and
expressed equivalently high levels of 
1,3-fucosyltransferase VII
(FucT-VII) as wild-type Th1 cells. FucT-VII expression was induced by T
cell activation, and was enhanced by IL-12 independently of Stat4,
whereas C2GlcNAcT-I up-regulation was mediated exclusively by IL-12,
acting through Stat4. These data show that FucT-VII and C2GlcNAcT-I are
controlled through distinct pathways and imply the existence of at
least one other IL-12-inducible glycosyltransferase required for
E-selectin and possibly P-selectin ligand formation in Th1
cells.
This article has been cited by other articles:
|
|
 |
|
  Y. Cao, P. D. Doodes, T. T. Glant, and A. Finnegan IL-27 Induces a Th1 Immune Response and Susceptibility to Experimental Arthritis J. Immunol., January 15, 2008; 180(2): 922 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jennrich, B. A. Ratsch, A. Hamann, and U. Syrbe Long-Term Commitment to Inflammation-Seeking Homing in CD4+ Effector Cells J. Immunol., June 15, 2007; 178(12): 8073 - 8080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Mathur, H.-C. Chang, D. G. Zisoulis, G. L. Stritesky, Q. Yu, J. T. O'Malley, R. Kapur, D. E. Levy, G. S. Kansas, and M. H. Kaplan Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells J. Immunol., April 15, 2007; 178(8): 4901 - 4907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Syrbe, U. Hoffmann, K. Schlawe, O. Liesenfeld, K. Erb, and A. Hamann Microenvironment-Dependent Requirement of STAT4 for the Induction of P-Selectin Ligands and Effector Cytokines on CD4+ T Cells in Healthy and Parasite-Infected Mice J. Immunol., December 1, 2006; 177(11): 7673 - 7679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ni, J. J. Campbell, G. Niehans, and B. Walcheck The Monoclonal Antibody CHO-131 Identifies a Subset of Cutaneous Lymphocyte-Associated Antigen T Cells Enriched in P-Selectin-Binding Cells J. Immunol., October 1, 2006; 177(7): 4742 - 4748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Koelle, J. Huang, M. T. Hensel, and C. L. McClurkan Innate Immune Responses to Herpes Simplex Virus Type 2 Influence Skin Homing Molecule Expression by Memory CD4+ Lymphocytes J. Virol., March 15, 2006; 80(6): 2863 - 2872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Underhill, D. G. Zisoulis, K. P. Kolli, L. G. Ellies, J. D. Marth, and G. S. Kansas A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells Blood, December 1, 2005; 106(12): 3867 - 3873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Satoh, Y. Kanai, M.-H. Wu, H. Yokozeki, R. Kannagi, J. B. Lowe, and K. Nishioka Synthesis of {alpha}(1,3) Fucosyltransferases IV- and VII-Dependent Eosinophil Selectin Ligand and Recruitment to the Skin Am. J. Pathol., September 1, 2005; 167(3): 787 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Carlow, M. J. Williams, and H. J. Ziltener Inducing P-Selectin Ligand Formation in CD8 T Cells: IL-2 and IL-12 Are Active In Vitro but Not Required In Vivo J. Immunol., April 1, 2005; 174(7): 3959 - 3966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Mora, G. Cheng, D. Picarella, M. Briskin, N. Buchanan, and U. H. von Andrian Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues J. Exp. Med., January 18, 2005; 201(2): 303 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Barry, D. G. Zisoulis, J. W. Neal, N. A. Clipstone, and G. S. Kansas Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells Blood, September 1, 2003; 102(5): 1771 - 1778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Haddad, C. J. Cooper, Z. Zhang, J. B. Brown, Y. Zhu, A. Issekutz, I. Fuss, H.-o. Lee, G. S. Kansas, and T. A. Barrett P-Selectin and P-Selectin Glycoprotein Ligand 1 Are Major Determinants for Th1 Cell Recruitment to Nonlymphoid Effector Sites in the Intestinal Lamina Propria J. Exp. Med., August 4, 2003; 198(3): 369 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Reinhardt, D. C. Bullard, C. T. Weaver, and M. K. Jenkins Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation J. Exp. Med., March 17, 2003; 197(6): 751 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Finnegan, M. J. Grusby, C. D. Kaplan, S. K. O'Neill, H. Eibel, T. Koreny, M. Czipri, K. Mikecz, and J. Zhang IL-4 and IL-12 Regulate Proteoglycan-Induced Arthritis Through Stat-Dependent Mechanisms J. Immunol., September 15, 2002; 169(6): 3345 - 3352. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
