| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St. Radboud, Nijmegen, The Netherlands;
Department of Pharmacology, NV Organon, Oss, The Netherlands; and
Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112
T cell IL-17 displays proinflammatory properties and is
expressed in the synovium of patients with rheumatoid arthritis. Its
contribution to the arthritic process has not been identified. Here, we
show that blocking of endogenous IL-17 in the autoimmune
collagen-induced arthritis model results in suppression of arthritis.
Also, joint damage was significantly reduced. In contrast,
overexpression of IL-17 enhanced collagen arthritis. Moreover,
adenoviral IL-17 injected in the knee joint of type II
collagen-immunized mice accelerated the onset and aggravated the
synovial inflammation at the site. Radiographic and histologic analysis
showed markedly increased joint destruction. Elevated levels of IL-1
protein were found in synovial tissue. Intriguingly, blocking of
IL-1
with neutralizing Abs had no effect on the IL-17-induced
inflammation and joint damage in the knee joint, implying an IL-1
independent pathway. This direct potency of IL-17 was underscored in
the unabated IL-17-induced exaggeration of bacterial cell
wall-induced arthritis in IL-1-/- mice. In conclusion,
this data shows that IL-17 contributes to joint destruction and
identifies an IL-1-independent role of IL-17. These findings suggest
IL-17 to be a novel target for the treatment of destructive arthritis
and may have implications for tissue destruction in other autoimmune
diseases.
This article has been cited by other articles:
|
|
 |
|
  I. Horie, N. Abiru, Y. Nagayama, G. Kuriya, O. Saitoh, T. Ichikawa, Y. Iwakura, and K. Eguchi T Helper Type 17 Immune Response Plays an Indispensable Role for Development of Iodine-Induced Autoimmune Thyroiditis in Nonobese Diabetic-H2h4 Mice Endocrinology, November 1, 2009; 150(11): 5135 - 5142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. OLIVITO, G. SIMONINI, S. CIULLINI, M. MORIONDO, L. BETTI, E. GAMBINERI, L. CANTARINI, M. DE MARTINO, C. AZZARI, and R. CIMAZ Th17 Transcription Factor RORC2 Is Inversely Correlated with FOXP3 Expression in the Joints of Children with Juvenile Idiopathic Arthritis J Rheumatol, September 1, 2009; 36(9): 2017 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Cui, H. Shao, C. Lan, H. Nian, R. L. O'Brien, W. K. Born, H. J. Kaplan, and D. Sun Major Role of {gamma}{delta} T Cells in the Generation of IL-17+ Uveitogenic T Cells J. Immunol., July 1, 2009; 183(1): 560 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Freitas, J. C. Alves-Filho, T. Victoni, T. Secher, H. P. Lemos, F. Sonego, F. Q. Cunha, and B. Ryffel IL-17 Receptor Signaling Is Required to Control Polymicrobial Sepsis J. Immunol., June 15, 2009; 182(12): 7846 - 7854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Boldizsar, O. Tarjanyi, P. Nemeth, K. Mikecz, and T. T. Glant Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice Int. Immunol., May 1, 2009; 21(5): 511 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. LEE, M.-L. CHO, J.-I. KIM, Y.-M. MOON, H.-J. OH, G.-T. KIM, S. RYU, S.-H. BAEK, S.-H. LEE, H.-Y. KIM, et al. Interleukin 17 (IL-17) Increases the Expression of Toll-like Receptor-2, 4, and 9 by Increasing IL-1{beta} and IL-6 Production in Autoimmune Arthritis J Rheumatol, April 1, 2009; 36(4): 684 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Voo, Y.-H. Wang, F. R. Santori, C. Boggiano, Y.-H. Wang, K. Arima, L. Bover, S. Hanabuchi, J. Khalili, E. Marinova, et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans PNAS, March 24, 2009; 106(12): 4793 - 4798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shahrara, S. R. Pickens, A. Dorfleutner, and R. M. Pope IL-17 Induces Monocyte Migration in Rheumatoid Arthritis J. Immunol., March 15, 2009; 182(6): 3884 - 3891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Perona-Wright, S. J. Jenkins, R. A. O'Connor, D. Zienkiewicz, H. J. McSorley, R. M. Maizels, S. M. Anderton, and A. S. MacDonald A Pivotal Role for CD40-Mediated IL-6 Production by Dendritic Cells during IL-17 Induction In Vivo J. Immunol., March 1, 2009; 182(5): 2808 - 2815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ke, K. Liu, G.-Q. Huang, Y. Cui, H. J. Kaplan, H. Shao, and D. Sun Anti-Inflammatory Role of IL-17 in Experimental Autoimmune Uveitis J. Immunol., March 1, 2009; 182(5): 3183 - 3190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W Niedbala, B Cai, X Wei, A Patakas, B P Leung, I B McInnes, and F Y Liew Interleukin 27 attenuates collagen-induced arthritis Ann Rheum Dis, October 1, 2008; 67(10): 1474 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kochetkova, T. Trunkle, G. Callis, and D. W. Pascual Vaccination without Autoantigen Protects against Collagen II-Induced Arthritis via Immune Deviation and Regulatory T Cells J. Immunol., August 15, 2008; 181(4): 2741 - 2752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Rankin, A. J. Reed, S. Oh, C. Cozzo Picca, H. M. Guay, J. Larkin III, L. Panarey, M. K. Aitken, B. Koeberlein, P. E. Lipsky, et al. CD4+ T Cells Recognizing a Single Self-Peptide Expressed by APCs Induce Spontaneous Autoimmune Arthritis J. Immunol., January 15, 2008; 180(2): 833 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cao, P. D. Doodes, T. T. Glant, and A. Finnegan IL-27 Induces a Th1 Immune Response and Susceptibility to Experimental Arthritis J. Immunol., January 15, 2008; 180(2): 922 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Nardelli, S. M. Callister, and R. F. Schell Lyme Arthritis: Current Concepts and a Change in Paradigm Clin. Vaccine Immunol., January 1, 2008; 15(1): 21 - 34. [Full Text] [PDF]
|
|
|
|
|
|
H. W. Lim, J. Lee, P. Hillsamer, and C. H. Kim Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells J. Immunol., January 1, 2008; 180(1): 122 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Moisan, R. Grenningloh, E. Bettelli, M. Oukka, and I-C. Ho Ets-1 is a negative regulator of Th17 differentiation J. Exp. Med., November 26, 2007; 204(12): 2825 - 2835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamaguchi, K. Fujio, H. Shoda, A. Okamoto, N. H. Tsuno, K. Takahashi, and K. Yamamoto IL-17B and IL-17C Are Associated with TNF-{alpha} Production and Contribute to the Exacerbation of Inflammatory Arthritis J. Immunol., November 15, 2007; 179(10): 7128 - 7136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Peng, G. Han, H. Shao, Y. Wang, H. J. Kaplan, and D. Sun Characterization of IL-17+ Interphotoreceptor Retinoid-Binding Protein-Specific T Cells in Experimental Autoimmune Uveitis Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4153 - 4161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Niki, H. Takaishi, J. Takito, T. Miyamoto, N. Kosaki, H. Matsumoto, Y. Toyama, and N. Tada Administration of Cyclooxygenase-2 Inhibitor Reduces Joint Inflammation but Exacerbates Osteopenia in IL-1{alpha} Transgenic Mice Due to GM-CSF Overproduction J. Immunol., July 1, 2007; 179(1): 639 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Coppieters, P. Dewint, K. Van Beneden, P. Jacques, S. Seeuws, G. Verbruggen, D. Deforce, and D. Elewaut NKT cells: manipulable managers of joint inflammation Rheumatology, April 1, 2007; 46(4): 565 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M I Koenders, L A B Joosten, and W B van den Berg Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis Ann Rheum Dis, November 1, 2006; 65(suppl_3): iii29 - iii33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tan, W. Huang, Q. Zhong, and P. Schwarzenberger IL-17 Receptor Knockout Mice Have Enhanced Myelotoxicity and Impaired Hemopoietic Recovery Following Gamma Irradiation J. Immunol., May 15, 2006; 176(10): 6186 - 6193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Koenders, E. Lubberts, F. A. J. van de Loo, B. Oppers-Walgreen, L. van den Bersselaar, M. M. Helsen, J. K. Kolls, F. E. Di Padova, L. A. B. Joosten, and W. B. van den Berg Interleukin-17 Acts Independently of TNF-{alpha} under Arthritic Conditions J. Immunol., May 15, 2006; 176(10): 6262 - 6269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Kramer, L. Yi, F. Shen, A. Maitra, X. Jiao, T. Jin, and S. L. Gaffen Cutting Edge: Evidence for Ligand-Independent Multimerization of the IL-17 Receptor J. Immunol., January 15, 2006; 176(2): 711 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Jenmalm, H. Cherwinski, E. P. Bowman, J. H. Phillips, and J. D. Sedgwick Regulation of Myeloid Cell Function through the CD200 Receptor J. Immunol., January 1, 2006; 176(1): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lubberts, P. Schwarzenberger, W. Huang, J. R. Schurr, J. J. Peschon, W. B. van den Berg, and J. K. Kolls Requirement of IL-17 Receptor Signaling in Radiation-Resistant Cells in the Joint for Full Progression of Destructive Synovitis J. Immunol., September 1, 2005; 175(5): 3360 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Koenders, E. Lubberts, B. Oppers-Walgreen, L. van den Bersselaar, M. M. Helsen, F. E. Di Padova, A. M.H. Boots, H. Gram, L. A.B. Joosten, and W. B. van den Berg Blocking of Interleukin-17 during Reactivation of Experimental Arthritis Prevents Joint Inflammation and Bone Erosion by Decreasing RANKL and Interleukin-1 Am. J. Pathol., July 1, 2005; 167(1): 141 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Latham, K. B. Whittington, R. Zhou, Z. Qian, and E. F. Rosloniec Ex Vivo Characterization of the Autoimmune T Cell Response in the HLA-DR1 Mouse Model of Collagen-Induced Arthritis Reveals Long-Term Activation of Type II Collagen-Specific Cells and Their Presence in Arthritic Joints J. Immunol., April 1, 2005; 174(7): 3978 - 3985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Nardelli, M. A. Burchill, D. M. England, J. Torrealba, S. M. Callister, and R. F. Schell Association of CD4+ CD25+ T Cells with Prevention of Severe Destructive Arthritis in Borrelia burgdorferi-Vaccinated and Challenged Gamma Interferon-Deficient Mice Treated with Anti-Interleukin-17 Antibody Clin. Vaccine Immunol., November 1, 2004; 11(6): 1075 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakae, A. Nambu, K. Sudo, and Y. Iwakura Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice J. Immunol., December 1, 2003; 171(11): 6173 - 6177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Burchill, D. T. Nardelli, D. M. England, D. J. DeCoster, J. A. Christopherson, S. M. Callister, and R. F. Schell Inhibition of Interleukin-17 Prevents the Development of Arthritis in Vaccinated Mice Challenged with Borrelia burgdorferi Infect. Immun., June 1, 2003; 71(6): 3437 - 3442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakae, S. Saijo, R. Horai, K. Sudo, S. Mori, and Y. Iwakura IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist PNAS, May 13, 2003; 100(10): 5986 - 5990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Silverman, D. O. Zamora, Y. Pan, P. V. Texeira, S.-H. Baek, S. R. Planck, and J. T. Rosenbaum Constitutive and Inflammatory Mediator-Regulated Fractalkine Expression in Human Ocular Tissues and Cultured Cells Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1608 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lubberts, L. van den Bersselaar, B. Oppers-Walgreen, P. Schwarzenberger, C. J. J. Coenen-de Roo, J. K. Kolls, L. A. B. Joosten, and W. B. van den Berg IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-{kappa}B Ligand/Osteoprotegerin Balance J. Immunol., March 1, 2003; 170(5): 2655 - 2662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ferretti, O. Bonneau, G. R. Dubois, C. E. Jones, and A. Trifilieff IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger J. Immunol., February 15, 2003; 170(4): 2106 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Gracie, S. E. Robertson, and I. B. McInnes Interleukin-18 J. Leukoc. Biol., February 1, 2003; 73(2): 213 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Kolls, S. T. Kanaly, and A. J. Ramsay Interleukin-17: An Emerging Role in Lung Inflammation Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 9 - 11. [Full Text] [PDF]
|
|
|
|
|
|
J. Maertzdorf, A. D. M. E. Osterhaus, and G. M. G. M. Verjans IL-17 Expression in Human Herpetic Stromal Keratitis: Modulatory Effects on Chemokine Production by Corneal Fibroblasts J. Immunol., November 15, 2002; 169(10): 5897 - 5903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P J Koshy, N Henderson, C Logan, P F Life, T E Cawston, and A D Rowan Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines Ann Rheum Dis, August 1, 2002; 61(8): 704 - 713. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
