| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Graduate Program in Immunology/Virology and
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605;
Children’s Memorial Hospital, Northwestern University, Chicago, IL 60614;
University of Medicine and Dentistry of New Jersey, Newark, NJ 07103;
¶ Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA 02115; and
||
University of Mississippi Medical School, Jackson, MS 39216
Early potent combination antiretroviral therapies (ART) for HIV-1
infection can preserve or restore immune function, but control of viral
replication early in infection may interfere with the development of
HIV-1-specific immune responses. Using an IFN-
ELISPOT assay, we
evaluated the breadth and intensity of HIV-1-specific CD8+
T cell responses in 17 vertically infected infants who began ART at
1–23 mo of age. CMV-specific responses were also characterized in
three infants coinfected with HIV-1 and CMV. Before ART, HIV-1-specific
CD8+ T cell responses were detected in two of 13 (15%)
infants <6 mo of age. HIV-1-specific CD8+ T cells became
undetectable in these two infants after the control of viral
replication. Intermittent HIV-1-specific responses were noted in six
infants who did not experience durable control of viral replication. In
contrast, HIV-1-specific responses were detected before ART in four of
four infants >6 mo of age and became persistently undetectable in only
one child. CMV-specific CD8+ T cell responses were
persistently detected in all HIV-1 and CMV coinfected infants. In
conclusion, HIV-1-specific CD8+ T cell responses were less
commonly detected before therapy in young infants than in older
infants. Suppression of viral replication appeared to interfere with
the development and maintenance of HIV-1-specific CD8+ T
cell responses. The detection of CMV-specific responses in HIV-1 and
CMV coinfected infants suggests a selective defect in the generation or
maintenance of HIV-1-specific CD8+ T cell responses.
Therapeutic HIV-1 vaccine strategies in young infants may prolong the
clinical benefit of ART by expanding the HIV-1-specific
CD8+ T cell pool.
This article has been cited by other articles:
|
|
 |
|
  S. Huang, J. Dunkley-Thompson, Y. Tang, E. A. Macklin, J. Steel-Duncan, I. Singh-Minott, E. G. Ryland, M. Smikle, B. D. Walker, C. D. C. Christie, et al. Deficiency of HIV-Gag-Specific T Cells in Early Childhood Correlates with Poor Viral Containment J. Immunol., December 1, 2008; 181(11): 8103 - 8111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Liang Evaluation of change in CD4+ cell counts in AIDS clinical trials Statistical Methods in Medical Research, April 1, 2008; 17(2): 141 - 150. [Abstract] [PDF]
|
|
|
|
 |
|
 C. F. Thobakgale, D. Ramduth, S. Reddy, N. Mkhwanazi, C. de Pierres, E. Moodley, W. Mphatswe, N. Blanckenberg, A. Cengimbo, A. Prendergast, et al. Human Immunodeficiency Virus-Specific CD8+ T-Cell Activity Is Detectable from Birth in the Majority of In Utero-Infected Infants J. Virol., December 1, 2007; 81(23): 12775 - 12784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. A. Van Rompay, R. P. Singh, W. Heneine, J. A. Johnson, D. C. Montefiori, N. Bischofberger, and M. L. Marthas Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques. J. Virol., July 1, 2006; 80(13): 6399 - 6410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sanchez-Merino, S. Nie, and K. Luzuriaga HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants J. Immunol., November 15, 2005; 175(10): 6976 - 6986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Lohman, J. A. Slyker, B. A. Richardson, C. Farquhar, J. M. Mabuka, C. Crudder, T. Dong, E. Obimbo, D. Mbori-Ngacha, J. Overbaugh, et al. Longitudinal Assessment of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon Responses during the First Year of Life in HIV-1-Infected Infants J. Virol., July 1, 2005; 79(13): 8121 - 8130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chakraborty, A.-S. Morel, J. K. Sutton, V. Appay, R. M. Ripley, T. Dong, T. Rostron, S. Ogola, T. Palakudy, R. Musoke, et al. Correlates of Delayed Disease Progression in HIV-1-Infected Kenyan Children J. Immunol., June 15, 2005; 174(12): 8191 - 8199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Aandahl, M. F. Quigley, W. J. Moretto, M. Moll, V. D. Gonzalez, A. Sonnerborg, S. Lindback, F. M. Hecht, S. G. Deeks, M. G. Rosenberg, et al. Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment Blood, December 1, 2004; 104(12): 3672 - 3678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gibson, G. Piccinini, D. Lilleri, M. G. Revello, Z. Wang, S. Markel, D. J. Diamond, and K. Luzuriaga Human Cytomegalovirus Proteins pp65 and Immediate Early Protein 1 Are Common Targets for CD8+ T Cell Responses in Children with Congenital or Postnatal Human Cytomegalovirus Infection J. Immunol., February 15, 2004; 172(4): 2256 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Feeney, R. Draenert, K. A. Roosevelt, S. I. Pelton, K. McIntosh, S. K. Burchett, C. Mao, B. D. Walker, and P. J. R. Goulder Reconstitution of Virus-Specific CD4 Proliferative Responses in Pediatric HIV-1 Infection J. Immunol., December 15, 2003; 171(12): 6968 - 6975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Feeney, K. A. Roosevelt, Y. Tang, K. J. Pfafferott, K. McIntosh, S. K. Burchett, C. Mao, B. D. Walker, and P. J. R. Goulder Comprehensive Screening Reveals Strong and Broadly Directed Human Immunodeficiency Virus Type 1-Specific CD8 Responses in Perinatally Infected Children J. Virol., July 1, 2003; 77(13): 7492 - 7501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. A. Scott, C. M. Beaumier, M. Sharkey, M. Stevenson, and K. Luzuriaga HIV-1 Replication Increases HIV-Specific CD4+ T Cell Frequencies but Limits Proliferative Capacity in Chronically Infected Children J. Immunol., June 1, 2003; 170(11): 5786 - 5792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Sandberg, N. M. Fast, K. A. Jordan, S. N. Furlan, J. D. Barbour, G. Fennelly, J. Dobroszycki, H. M. L. Spiegel, A. Wiznia, M. G. Rosenberg, et al. HIV-Specific CD8+ T Cell Function in Children with Vertically Acquired HIV-1 Infection Is Critically Influenced by Age and the State of the CD4+ T Cell Compartment J. Immunol., April 15, 2003; 170(8): 4403 - 4410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. A. Van Rompay, J. L. Greenier, K. S. Cole, P. Earl, B. Moss, J. D. Steckbeck, B. Pahar, T. Rourke, R. C. Montelaro, D. R. Canfield, et al. Immunization of Newborn Rhesus Macaques with Simian Immunodeficiency Virus (SIV) Vaccines Prolongs Survival after Oral Challenge with Virulent SIVmac251 J. Virol., December 6, 2002; 77(1): 179 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Buseyne, D. Scott-Algara, F. Porrot, B. Corre, N. Bellal, M. Burgard, C. Rouzioux, S. Blanche, and Y. Riviere Frequencies of Ex Vivo-Activated Human Immunodeficiency Virus Type 1-Specific Gamma-Interferon-Producing CD8+ T Cells in Infected Children Correlate Positively with Plasma Viral Load J. Virol., November 13, 2002; 76(24): 12414 - 12422. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
