The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Evans, D. E.
Right arrow Articles by Weinberg, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Evans, D. E.
Right arrow Articles by Weinberg, A. D.
The Journal of Immunology, 2001, 167: 6804-6811.
Copyright © 2001 by The American Association of Immunologists

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of {alpha}OX-40 with {alpha}CTLA-41

Dean E. Evans*, Rodney A. Prell*, Colin J. Thalhofer*, Arthur A. Hurwitz{dagger} and Andrew D. Weinberg2,*

* Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Portland, OR 97213; and {dagger} Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210

Increasing the long-term survival of memory T cells after immunization is key to a successful vaccine. In the past, the generation of large numbers of memory T cells in vivo has been difficult because Ag-stimulated T cells are susceptible to activation-induced cell death. Previously, we reported that OX40 engagement resulted in a 60-fold increase in the number of Ag-specific CD4+ memory T cells that persisted 60 days postimmunization. In this report, we used the D011.10 adoptive transfer model to examine the kinetics of Ag-specific T cell entry into the peripheral blood, the optimal route of administration of Ag and {alpha}OX40, and the Ag-specific Ab response after immunization with soluble OVA and {alpha}OX40. Finally, we compared the adjuvant properties of {alpha}OX40 to those of {alpha}CTLA-4. Engagement of OX-40 in vivo was most effective when the Ag was administered s.c. Time course studies revealed that it was crucial for {alpha}OX40 to be delivered within 24–48 h after Ag exposure. Examination of anti-OVA Ab titers revealed a 10-fold increase in mice that received {alpha}OX40 compared with mice that received OVA alone. Both {alpha}OX40 and {alpha}CTLA-4 increased the percentage of OVA-specific CD4+ T cells early after immunization (day 4), but {alpha}OX40-treated mice had much higher percentages of OVA-specific memory CD4+ T cells from days 11 to 29. These studies demonstrate that OX40 engagement early after immunization with soluble Ag enhances long-term T cell and humoral immunity in a manner distinct from that provided by blocking CTLA-4.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
M. J. Gough, C. E. Ruby, W. L. Redmond, B. Dhungel, A. Brown, and A. D. Weinberg
OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor
Cancer Res., July 1, 2008; 68(13): 5206 - 5215.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. E. Ruby, R. Montler, R. Zheng, S. Shu, and A. D. Weinberg
IL-12 Is Required for Anti-OX40-Mediated CD4 T Cell Survival
J. Immunol., February 15, 2008; 180(4): 2140 - 2148.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. L. Redmond, M. J. Gough, B. Charbonneau, T. L. Ratliff, and A. D. Weinberg
Defects in the Acquisition of CD8 T Cell Effector Function after Priming with Tumor or Soluble Antigen Can Be Overcome by the Addition of an OX40 Agonist
J. Immunol., December 1, 2007; 179(11): 7244 - 7253.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. R. Humphreys, A. Loewendorf, C. de Trez, K. Schneider, C. A. Benedict, M. W. Munks, C. F. Ware, and M. Croft
OX40 Costimulation Promotes Persistence of Cytomegalovirus-Specific CD8 T Cells: A CD4-Dependent Mechanism
J. Immunol., August 15, 2007; 179(4): 2195 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Fukushima, T. Yamaguchi, W. Ishida, K. Fukata, H. Yagita, and H. Ueno
Roles of OX40 in the Development of Murine Experimental Allergic Conjunctivitis: Exacerbation and Attenuation by Stimulation and Blocking of OX40
Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 657 - 663.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. D. Vu, M. R. Clarkson, H. Yagita, L. A. Turka, M. H. Sayegh, and X. C. Li
Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection
J. Immunol., February 1, 2006; 176(3): 1394 - 1401.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Valzasina, C. Guiducci, H. Dislich, N. Killeen, A. D. Weinberg, and M. P. Colombo
Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR
Blood, April 1, 2005; 105(7): 2845 - 2851.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Biagi, G. Dotti, E. Yvon, E. Lee, M. Pule, S. Vigouroux, S. Gottschalk, U. Popat, R. Rousseau, and M. Brenner
Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes
Blood, March 15, 2005; 105(6): 2436 - 2442.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S.-H. Tseng, Y. Chen, C.-J. Chang, K.-F. Tai, S.-M. Lin, and L.-H. Hwang
Induction of T-Cell Apoptosis in Rats by Genetically Engineered Glioma Cells Expressing Granulocyte-Macrophage Colony-Stimulating Factor and B7.1
Clin. Cancer Res., February 15, 2005; 11(4): 1639 - 1649.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. D. Weinberg, D. E. Evans, C. Thalhofer, T. Shi, and R. A. Prell
The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement
J. Leukoc. Biol., June 1, 2004; 75(6): 962 - 972.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. K. Lathrop, C. A. Huddleston, P. A. Dullforce, M. J. Montfort, A. D. Weinberg, and D. C. Parker
A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions
J. Immunol., June 1, 2004; 172(11): 6735 - 6743.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. A. Prell, D. E. Evans, C. Thalhofer, T. Shi, C. Funatake, and A. D. Weinberg
OX40-Mediated Memory T Cell Generation Is TNF Receptor-Associated Factor 2 Dependent
J. Immunol., December 1, 2003; 171(11): 5997 - 6005.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. R. Humphreys, L. Edwards, G. Walzl, A. J. Rae, G. Dougan, S. Hill, and T. Hussell
OX40 Ligation on Activated T Cells Enhances the Control of Cryptococcus neoformans and Reduces Pulmonary Eosinophilia
J. Immunol., June 15, 2003; 170(12): 6125 - 6132.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. R. Blazar, A. H. Sharpe, A. I. Chen, A. Panoskaltsis-Mortari, C. Lees, H. Akiba, H. Yagita, N. Killeen, and P. A. Taylor
Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
Blood, May 1, 2003; 101(9): 3741 - 3748.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. J. Ekkens, Z. Liu, Q. Liu, J. Whitmire, S. Xiao, A. Foster, J. Pesce, J. VanNoy, A. H. Sharpe, J. F. Urban, et al.
The Role of OX40 Ligand Interactions in the Development of the Th2 Response to the Gastrointestinal Nematode Parasite Heligmosomoides polygyrus
J. Immunol., January 1, 2003; 170(1): 384 - 393.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.