| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Catenin in Human Monocytes1
*
Institute of Zoology, Department of Immunobiology, University of Leipzig, Leipzig, Germany; and
Medizinische Klinik II, Department of Internal Medicine, University of Leipzig, Max Bürger Research Center, Leipzig, Germany
In this study, we demonstrate that adherence factors, serum
constituents, LPS, and zymosan are capable of inducing a cellular
accumulation of 
-catenin in human monocytes. Whereas
adherence-dependent accumulation of -catenin can be blocked by
wortmannin, an inhibitor of phosphatidylinositol 3-kinase, accumulation
induced by the remaining stimuli cannot be prevented by inhibition of
phosphatidylinositol 3-kinase, implying the involvement of -catenin
in other not yet described signal transduction pathways. A role of
-catenin in adherence-dependent processes by interacting with
classical cadherins can be excluded as we could not detect cadherins in
monocytes. To test whether it is possible that -catenin interacts
with LEF/TCF (lymphoid enhancer factor/T cell factor) transcription
factors, we studied the expression of this protein family. TCF-4 was
identified as the LEF/TCF transcription factor present in human
monocytes. However, neither cellular induction of -catenin nor
cotransfection experiments with -catenin conducted in the monocytic
cell line THP-1 resulted in the activation of a LEF/TCF-dependent
promoter, suggesting the requirement of additional signals. Concurrent
with this suggestion, we found that LPS and zymosan, two physiological
inducers of -catenin, caused an increase in the expression of genes
that are positively regulated by -catenin.
This article has been cited by other articles:
|
|
 |
|
  J. L. Larabee, K. DeGiusti, J. L. Regens, and J. D. Ballard Bacillus anthracis Edema Toxin Activates Nuclear Glycogen Synthase Kinase 3{beta} Infect. Immun., November 1, 2008; 76(11): 4895 - 4904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. George Wnt Pathway: A New Role in Regulation of Inflammation Arterioscler. Thromb. Vasc. Biol., March 1, 2008; 28(3): 400 - 402. [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tillie-Leblond, P. Gosset, R. Le Berre, A. Janin, T. Prangere, A. B. Tonnel, and B. P. H. Guery Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats Eur. Respir. J., July 1, 2007; 30(1): 31 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tickenbrock, J. Schwable, A. Strey, B. Sargin, S. Hehn, M. Baas, C. Choudhary, V. Gerke, W. E. Berdel, C. Muller-Tidow, et al. Wnt signaling regulates transendothelial migration of monocytes J. Leukoc. Biol., June 1, 2006; 79(6): 1306 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Everly Jr., S. Kusano, and N. Raab-Traub Accumulation of Cytoplasmic {beta}-Catenin and Nuclear Glycogen Synthase Kinase 3{beta} in Epstein-Barr Virus-Infected Cells J. Virol., November 1, 2004; 78(21): 11648 - 11655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sun, M. E. Hobert, A. S. Rao, A. S. Neish, and J. L. Madara Bacterial activation of {beta}-catenin signaling in human epithelia Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G220 - G227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-Q. Li, R. E. Person, K.-I. Takemaru, K. Williams, K. Meade-White, A. H. Ozsahin, T. Gungor, R. T. Moon, and M. Horwitz Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor {alpha} Regulation of ELA2 J. Biol. Chem., January 23, 2004; 279(4): 2873 - 2884. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
