The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dai, Z.
Right arrow Articles by Lakkis, F. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dai, Z.
Right arrow Articles by Lakkis, F. G.
The Journal of Immunology, 2001, 167: 6711-6715.
Copyright © 2001 by The American Association of Immunologists

Cutting Edge

Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool1

Zhenhua Dai2 and Fadi G. Lakkis2

Sections of Nephrology and Immunobiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520

Despite declining thymic output with age, the peripheral naive T cell pool of an adult animal remains remarkably stable. Therefore, a central question in immunology is how the naive T cell pool is maintained. Here we show that the maintenance of the naive CD4, but not CD8, T cell population in the thymectomized adult mouse is dependent on the presence of secondary lymphoid tissues. This finding is explained by the inability of naive CD4 T cells to sustain normal levels of the survival molecule Bcl-2 or to undergo homeostatic proliferation in the absence of secondary lymphoid organs. Thus, naive CD4 T cells must traffic through secondary lymphoid organs to maintain a stable CD4 pool while naive CD8 T cells encounter their survival and proliferation signals outside the organized structures of secondary lymphoid tissues.




This article has been cited by other articles:


Home page
 Infect. Immun.Home page
M. C. Souza, C. Penido, M. F. S. Costa, and M. G. Henriques
Mechanisms of T-Lymphocyte Accumulation during Experimental Pleural Infection Induced by Mycobacterium bovis BCG
Infect. Immun., December 1, 2008; 76(12): 5686 - 5693.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. F. Sieg, D. A. Bazdar, and M. M. Lederman
S-phase entry leads to cell death in circulating T cells from HIV-infected persons
J. Leukoc. Biol., June 1, 2008; 83(6): 1382 - 1387.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
B. Metzler, P. Gfeller, G. Wieczorek, J. Li, B. Nuesslein-Hildesheim, A. Katopodis, M. Mueller, and V. Brinkmann
Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure
Int. Immunol., May 1, 2008; 20(5): 633 - 644.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Gaspal, V. Bekiaris, M.-Y. Kim, D. R. Withers, S. Bobat, I. C. M. MacLennan, G. Anderson, P. J. Lane, and A. F. Cunningham
Critical Synergy of CD30 and OX40 Signals in CD4 T Cell Homeostasis and Th1 Immunity to Salmonella
J. Immunol., March 1, 2008; 180(5): 2824 - 2829.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Wang, H. Dai, N. Wan, Y. Moore, and Z. Dai
The Role for Monocyte Chemoattractant Protein-1 in the Generation and Function of Memory CD8+ T Cells
J. Immunol., March 1, 2008; 180(5): 2886 - 2893.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Giroux, E. Yurchenko, J. St.-Pierre, C. A. Piccirillo, and C. Perreault
T Regulatory Cells Control Numbers of NK Cells and CD8{alpha}+ Immature Dendritic Cells in the Lymph Node Paracortex
J. Immunol., October 1, 2007; 179(7): 4492 - 4502.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. M. Jelley-Gibbs, J. P. Dibble, D. M. Brown, T. M. Strutt, K. K. McKinstry, and S. L. Swain
Persistent Depots of Influenza Antigen Fail To Induce a Cytotoxic CD8 T Cell Response
J. Immunol., June 15, 2007; 178(12): 7563 - 7570.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Liu, H. Dai, N. Wan, T. Wang, S. Bertera, M. Trucco, and Z. Dai
Suppression of Memory CD8 T Cell Generation and Function by Tryptophan Catabolism
J. Immunol., April 1, 2007; 178(7): 4260 - 4266.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Y. Nishimura, T. Igarashi, A. Buckler-White, C. Buckler, H. Imamichi, R. M. Goeken, W. R. Lee, B. A. P. Lafont, R. Byrum, H. C. Lane, et al.
Loss of Naive Cells Accompanies Memory CD4+ T-Cell Depletion during Long-Term Progression to AIDS in Simian Immunodeficiency Virus-Infected Macaques
J. Virol., January 15, 2007; 81(2): 893 - 902.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
T. W. Schacker, J. M. Brenchley, G. J. Beilman, C. Reilly, S. E. Pambuccian, J. Taylor, D. Skarda, M. Larson, D. C. Douek, and A. T. Haase
Lymphatic Tissue Fibrosis Is Associated with Reduced Numbers of Naive CD4+ T Cells in Human Immunodeficiency Virus Type 1 Infection.
Clin. Vaccine Immunol., May 1, 2006; 13(5): 556 - 560.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. Obhrai, M. H. Oberbarnscheidt, T. W. Hand, L. Diggs, G. Chalasani, and F. G. Lakkis
Effector T Cell Differentiation and Memory T Cell Maintenance Outside Secondary Lymphoid Organs
J. Immunol., April 1, 2006; 176(7): 4051 - 4058.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. Penkov, P. Di Rosa, L. Fernandez Diaz, V. Basso, E. Ferretti, F. Grassi, A. Mondino, and F. Blasi
Involvement of Prep1 in the {alpha}{beta} T-Cell Receptor T-Lymphocytic Potential of Hematopoietic Precursors
Mol. Cell. Biol., December 15, 2005; 25(24): 10768 - 10781.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Gruber and T. Brocker
MHC Class I-Positive Dendritic Cells (DC) Control CD8 T Cell Homeostasis In Vivo: T Cell Lymphopenia as a Prerequisite for DC-Mediated Homeostatic Proliferation of Naive CD8 T Cells
J. Immunol., July 1, 2005; 175(1): 201 - 206.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. W. Nasr, Y. Wang, G. Gao, S. Deng, L. Diggs, D. M. Rothstein, G. Tellides, F. G. Lakkis, and Z. Dai
Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells
J. Immunol., May 15, 2005; 174(10): 6161 - 6168.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. M. Brenchley, T. W. Schacker, L. E. Ruff, D. A. Price, J. H. Taylor, G. J. Beilman, P. L. Nguyen, A. Khoruts, M. Larson, A. T. Haase, et al.
CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract
J. Exp. Med., September 20, 2004; 200(6): 749 - 759.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Chalasani, Q. Li, B. T. Konieczny, L. Smith-Diggs, B. Wrobel, Z. Dai, D. L. Perkins, F. K. Baddoura, and F. G. Lakkis
The Allograft Defines the Type of Rejection (Acute versus Chronic) in the Face of an Established Effector Immune Response
J. Immunol., June 15, 2004; 172(12): 7813 - 7820.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
F. G. Lakkis and M. H. Sayegh
Memory T Cells: A Hurdle to Immunologic Tolerance
J. Am. Soc. Nephrol., September 1, 2003; 14(9): 2402 - 2410.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Zhang, J. Guo, and Y.-W. He
Lymphocyte Accumulation in the Spleen of Retinoic Acid Receptor-Related Orphan Receptor {gamma}-Deficient Mice
J. Immunol., August 15, 2003; 171(4): 1667 - 1675.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. R. Permar, W. J. Moss, J. J. Ryon, D. C. Douek, M. Monze, and D. E. Griffin
Increased Thymic Output during Acute Measles Virus Infection
J. Virol., July 15, 2003; 77(14): 7872 - 7879.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.