| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Institute of Biochemistry, Swiss Federal Institute of Technology (Eidgenössiche Technische Hochschule), Zurich, Switzerland; and
Medical Research Council, Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Signal sequences of human MHC class I molecules are a unique source of epitopes for newly synthesized nonclassical HLA-E molecules. Binding of such conserved peptides to HLA-E induces its cell surface expression and protects cells from NK cell attack. After cleavage from the pre-protein, we show that the liberated MHC class I signal peptide is further processed by signal peptide peptidase in the hydrophobic, membrane-spanning region. This cut is essential for the release of the HLA-E epitope-containing fragment from the lipid bilayer and its subsequent transport into the lumen of the endoplasmic reticulum via the TAP.
This article has been cited by other articles:
|
|
 |
|
  R. Fluhrer, H. Steiner, and C. Haass Intramembrane Proteolysis by Signal Peptide Peptidases: A Comparative Discussion of GXGD-type Aspartyl Proteases J. Biol. Chem., May 22, 2009; 284(21): 13975 - 13979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Han, L. Green, and D. J. Schnell The Signal Peptide Peptidase Is Required for Pollen Function in Arabidopsis Plant Physiology, March 1, 2009; 149(3): 1289 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Robakis, B. Bak, S.-h. Lin, D. J. Bernard, and P. Scheiffele An Internal Signal Sequence Directs Intramembrane Proteolysis of a Cellular Immunoglobulin Domain Protein J. Biol. Chem., December 26, 2008; 283(52): 36369 - 36376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sato, K. Ananda, C. I. Cheng, E. J. Suh, S. Narayanan, and M. S. Wolfe Distinct Pharmacological Effects of Inhibitors of Signal Peptide Peptidase and {gamma}-Secretase J. Biol. Chem., November 28, 2008; 283(48): 33287 - 33295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. El Hage, V. Stroobant, I. Vergnon, J.-F. Baurain, H. Echchakir, V. Lazar, S. Chouaib, P. G. Coulie, and F. Mami-Chouaib Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway PNAS, July 22, 2008; 105(29): 10119 - 10124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Targett-Adams, G. Hope, S. Boulant, and J. McLauchlan Maturation of Hepatitis C Virus Core Protein by Signal Peptide Peptidase Is Required for Virus Production J. Biol. Chem., June 13, 2008; 283(24): 16850 - 16859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dultz, M. Hildenbeutel, B. Martoglio, J. Hochman, B. Dobberstein, and K. Kapp The Signal Peptide of the Mouse Mammary Tumor Virus Rem Protein Is Released from the Endoplasmic Reticulum Membrane and Accumulates in Nucleoli J. Biol. Chem., April 11, 2008; 283(15): 9966 - 9976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Iben, R. E. Olson, L. A. Balanda, S. Jayachandra, B. J. Robertson, V. Hay, J. Corradi, C. V. C. Prasad, R. Zaczek, C. F. Albright, et al. Signal Peptide Peptidase and {gamma}-Secretase Share Equivalent Inhibitor Binding Pharmacology J. Biol. Chem., December 21, 2007; 282(51): 36829 - 36836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Giraud, P.-J. Lejeune, J. Barbaria, and B. Mallet A Plasminogen-Like Protease in Thyroid Rough Microsomes Degrades Thyroperoxidase and Thyroglobulin Endocrinology, June 1, 2007; 148(6): 2886 - 2893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Targett-Adams, T. Schaller, G. Hope, R. E. Lanford, S. M. Lemon, A. Martin, and J. McLauchlan Signal Peptide Peptidase Cleavage of GB Virus B Core Protein Is Required for Productive Infection in Vivo J. Biol. Chem., September 29, 2006; 281(39): 29221 - 29227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vauloup-Fellous, V. Pene, J. Garaud-Aunis, F. Harper, S. Bardin, Y. Suire, E. Pichard, A. Schmitt, P. Sogni, G. Pierron, et al. Signal Peptide Peptidase-catalyzed Cleavage of Hepatitis C Virus Core Protein Is Dispensable for Virus Budding but Destabilizes the Viral Capsid J. Biol. Chem., September 22, 2006; 281(38): 27679 - 27692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Boulant, R. Montserret, R. G. Hope, M. Ratinier, P. Targett-Adams, J.-P. Lavergne, F. Penin, and J. McLauchlan Structural Determinants That Target the Hepatitis C Virus Core Protein to Lipid Droplets J. Biol. Chem., August 4, 2006; 281(31): 22236 - 22247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Nyborg, T. B. Ladd, K. Jansen, T. Kukar, and T. E. Golde Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase FASEB J, August 1, 2006; 20(10): 1671 - 1679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Matsumi, H. Atomi, and T. Imanaka Identification of the Amino Acid Residues Essential for Proteolytic Activity in an Archaeal Signal Peptide Peptidase J. Biol. Chem., April 14, 2006; 281(15): 10533 - 10539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Matsumi, H. Atomi, and T. Imanaka Biochemical Properties of a Putative Signal Peptide Peptidase from the Hyperthermophilic Archaeon Thermococcus kodakaraensis KOD1 J. Bacteriol., October 15, 2005; 187(20): 7072 - 7080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Casso, S. Tanda, B. Biehs, B. Martoglio, and T. B. Kornberg Drosophila Signal Peptide Peptidase Is an Essential Protease for Larval Development Genetics, May 1, 2005; 170(1): 139 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Urban and M. S. Wolfe Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity PNAS, February 8, 2005; 102(6): 1883 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Friedmann, M. K. Lemberg, A. Weihofen, K. K. Dev, U. Dengler, G. Rovelli, and B. Martoglio Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins J. Biol. Chem., December 3, 2004; 279(49): 50790 - 50798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Grigorenko, Y. K. Moliaka, M. C. Soto, C. C. Mello, and E. I. Rogaev The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins PNAS, October 12, 2004; 101(41): 14955 - 14960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Nyborg, K. Jansen, T. B. Ladd, A. Fauq, and T. E. Golde A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin J. Biol. Chem., October 8, 2004; 279(41): 43148 - 43156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Wolfe and R. Kopan Intramembrane Proteolysis: Theme and Variations Science, August 20, 2004; 305(5687): 1119 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Okamoto, K. Moriishi, T. Miyamura, and Y. Matsuura Intramembrane Proteolysis and Endoplasmic Reticulum Retention of Hepatitis C Virus Core Protein J. Virol., June 15, 2004; 78(12): 6370 - 6380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Nyborg, A. Y. Kornilova, K. Jansen, T. B. Ladd, M. S. Wolfe, and T. E. Golde Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed {gamma}-Secretase Inhibitor J. Biol. Chem., April 9, 2004; 279(15): 15153 - 15160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kambayashi, J. R. Kraft-Leavy, J. G. Dauner, B. A. Sullivan, O. Laur, and P. E. Jensen The Nonclassical MHC Class I Molecule Qa-1 Forms Unstable Peptide Complexes J. Immunol., February 1, 2004; 172(3): 1661 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Martoglio and T. E. Golde Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs Hum. Mol. Genet., October 15, 2003; 12(90002): R201 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Bland, M. K. Lemberg, A. J. McMichael, B. Martoglio, and V. M. Braud Requirement of the Proteasome for the Trimming of Signal Peptide-derived Epitopes Presented by the Nonclassical Major Histocompatibility Complex Class I Molecule HLA-E J. Biol. Chem., September 5, 2003; 278(36): 33747 - 33752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Miller, D. A. Weber, C. Ibegbu, J. Pohl, J. D. Altman, and P. E. Jensen Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2 J. Immunol., August 1, 2003; 171(3): 1369 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Weihofen, M. K. Lemberg, E. Friedmann, H. Rueeger, A. Schmitz, P. Paganetti, G. Rovelli, and B. Martoglio Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with gamma -Secretase Inhibitors J. Biol. Chem., May 2, 2003; 278(19): 16528 - 16533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Smith, A. Gallimore, E. Jones, B. Roberts, J. M. Lord, E. Deeks, V. Cerundolo, and L. M. Roberts Exogenous Peptides Delivered by Ricin Require Processing by Signal Peptidase for Transporter Associated with Antigen Processing-Independent MHC Class I-Restricted Presentation J. Immunol., July 1, 2002; 169(1): 99 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Weihofen, K. Binns, M. K. Lemberg, K. Ashman, and B. Martoglio Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease Science, June 21, 2002; 296(5576): 2215 - 2218. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
