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Kinetics of Antigen-Induced Phenotypic and Functional Maturation of Human Monocyte-Derived Dendritic Cells¹

Szu-Min Hsieh^2,3,*, Sung-Ching Pan^2,*, Chien-Ching Hung^2,, Hsing-Chun Tsai^*, Mao-Yuan Chen^*, Chun-Nan Lee and Shan-Chwen Chang^*

^* Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; and Departments of Parasitology and Medical Technology, National Taiwan University, Taipei, Taiwan

Dendritic cells (DCs), a critical component of innate immunity, are the most potent APCs. When DCs mature, they can elicit strong T cell responses. We studied the kinetics of Ag-induced phenotypic and functional maturation of human monocyte-derived DCs using an in vitro T cell-independent culture system. With this model, we herein show that an Ag that has recently or repetitively been exposed ("exposed Ag") rapidly induces a high level of maturation; however, an Ag that has never or only remotely been exposed ("unexposed Ag") slowly induces a low level of maturation. The kinetics of Ag-induced maturation of DCs possibly implies a novel mechanism for immunological memory that would provide maximal host protection from repetitively invading pathogens in the environment.

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