HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hsieh, S.-M. Articles by Chang, S.-C. Search for Related Content PubMed PubMed Citation Articles by Hsieh, S.-M. Articles by Chang, S.-C.

Kinetics of Antigen-Induced Phenotypic and Functional Maturation of Human Monocyte-Derived Dendritic Cells¹

Szu-Min Hsieh^2,3,*, Sung-Ching Pan^2,*, Chien-Ching Hung^2,, Hsing-Chun Tsai^*, Mao-Yuan Chen^*, Chun-Nan Lee and Shan-Chwen Chang^*

^* Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; and Departments of Parasitology and Medical Technology, National Taiwan University, Taipei, Taiwan

Dendritic cells (DCs), a critical component of innate immunity, are the most potent APCs. When DCs mature, they can elicit strong T cell responses. We studied the kinetics of Ag-induced phenotypic and functional maturation of human monocyte-derived DCs using an in vitro T cell-independent culture system. With this model, we herein show that an Ag that has recently or repetitively been exposed ("exposed Ag") rapidly induces a high level of maturation; however, an Ag that has never or only remotely been exposed ("unexposed Ag") slowly induces a low level of maturation. The kinetics of Ag-induced maturation of DCs possibly implies a novel mechanism for immunological memory that would provide maximal host protection from repetitively invading pathogens in the environment.

This article has been cited by other articles:

				S.-M. Hsieh and S.-C. Chang Cutting Edge: Insufficient Perforin Expression in CD8+ T Cells in Response to Hemagglutinin from Avian Influenza (H5N1) Virus. J. Immunol., April 15, 2006; 176(8): 4530 - 4533. [Abstract] [Full Text] [PDF]