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*
Department of Dermatology, Geneva University Medical Center, Geneva, Switzerland;
Institute of Biochemistry, Lausanne University, Epalinges, Switzerland; and
Apotech Biochemicals, Epalinges, Switzerland
The TNF ligand family member B cell-activating factor belonging to TNF family (BAFF, also called Blys, TALL-1, zTNF-4, or THANK) is an important survival factor for B cells. In this study, we show that BAFF is able to regulate T cell activation. rBAFF induced responses (thymidine incorporation and cytokine secretion) of T cells, suboptimally stimulated through their TCR. BAFF activity was observed on naive, as well as on effector/memory T cells (both CD4+ and CD8+ subsets), indicating that BAFF has a wide function on T cell responses. Analysis of the signal transduced by BAFF into T cells shows that BAFF has no obvious effect on T cell survival upon activation, but is able to deliver a complete costimulation signal into T cells. Indeed, BAFF is sufficient to induce IL-2 secretion and T cell division, when added to an anti-TCR stimulation. This highlights some differences in the BAFF signaling pathway in T and B cells. In conclusion, our results indicate that BAFF may play a role in the development of T cell responses, in addition to its role in B cell homeostasis.
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