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Cutting Edge |
,¶
*
U.S. Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Immunology and Disease Resistance Laboratory, Beltsville, MD 20705;
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814;
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814;
Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267; and
¶ Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220
Expulsion of two gastrointestinal nematode parasites,
Nippostrongylus brasiliensis and Trichinella
spiralis, is similar in that both require IL-4R
expression,
but different in that T cells and mast cells are required for
IL-4-induced expulsion of T. spiralis but not N.
brasiliensis. To examine the role of IL-4R signaling in
immunity to these parasites, we studied worm expulsion in chimeric mice
that selectively expressed IL-4R on bone marrow-derived or non-bone
marrow-derived cells. N. brasiliensis was expelled by
mice that expressed IL-4R only on non-bone marrow-derived cells, but
not by mice that expressed IL-4R only on bone marrow-derived cells.
Although T. spiralis expulsion required IL-4R
expression by both bone marrow- and non-bone marrow-derived cells, IL-4
stimulation eliminated the requirement for IL-4R expression by bone
marrow-derived cells. Thus, direct IL-4R signaling of nonimmune
gastrointestinal cells may be generally required to induce worm
expulsion, even when mast cell and T cell responses are also
required.
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