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17 by Peripheral and Cutaneous T Cells in Nickel-Induced Contact Dermatitis1
*
Department of Dermatology and
Interdisciplinary Center for Clinical Research, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany;
MDS Pharma Services, Hamburg, Germany; and
Department of Dermatology, University ofErlangen, Erlangen, Germany
Nickel (Ni) is one of the most common contact sensitizers in man,
and Ni-induced contact dermatitis is considered as a model of
hapten-induced delayed type hypersensitivity. Previous studies
indicated that Ni-reactive T cells derived from Ni-allergic individuals
preferentially express distinct TCR-V
chains. However, data on the
TCR-V repertoire of Ni-responsive T cells are not consistent.
Therefore, the aim of this study was to identify the TCR-V receptors
of Ni-responsive peripheral and cutaneous T cells in a cohort of 17
donors with Ni-induced contact dermatitis in comparison with those of 6
healthy controls. Peripheral NiSO4-responsive T lymphocytes
showed a significant overexpression of TCR-V17 and the frequency of
TCR-V17+ T cells correlated significantly with the in
vitro reactivity of PBMC to NiSO4. In addition, the
cutaneous infiltrate of Ni-induced patch test reactions consisted
primarily of V17+ T cells. The majority of patch
test-derived NiSO4-responsive T cells of three allergic
donors were TCR-V17+, whereas patch test-derived
NiSO4 unresponsive T cells of four additional donors did
not express TCR-V17. Skin-derived Ni-responsive T cell lines from
three donors uniformly secreted the Th2 cytokine, IL-5, but no IFN-
or IL-10. These in vitro and in vivo findings strongly suggest that T
cells with a restricted TCR-V repertoire, i.e., V17, predominate
in NiSO4-induced contact dermatitis and may be crucial in
the effector phase of Ni hypersensitivity.
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