| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Schering-Plough Laboratory for Immunological Research, Dardilly, France;
Cell Biology and Institute of Biomembranes, University Medical Centre, Utrecht, The Netherlands;
Institut National de la Santé et de la Recherche Médicale Unité 346, Centre Hospitalier Edouard Herriot, Lyon, France; and
DNAX Research Institute, Palo Alto, CA 94304
In a search for genes expressed by dendritic cells (DC), we have cloned cDNAs encoding different forms of an asialoglycoprotein receptor (ASGPR). The DC-ASGPR represents long and short isoforms of human macrophage lectin, a Ca2+-dependent type II transmembrane lectin displaying considerable homology with the H1 and H2 subunits of the hepatic ASGPR. Immunoprecipitation from DC using an anti-DC-ASGPR mAb yielded a major 40-kDa protein with an isoelectric point of 8.2. DC-ASGPR mRNA was observed predominantly in immune tissues. Both isoforms were detected in DC and granulocytes, but not in T, B, or NK cells, or monocytes. DC-ASGPR species were restricted to the CD14-derived DC obtained from CD34+ progenitors, while absent from the CD1a-derived subset. Accordingly, both monocyte-derived DC and tonsillar interstitial-type DC expressed DC-ASGPR protein, while Langerhans-type cells did not. Furthermore, DC-ASGPR is a feature of immaturity, as expression was lost upon CD40 activation. In agreement with the presence of tyrosine-based and dileucine motifs in the intracytoplasmic domain, mAb against DC-ASGPR was rapidly internalized by DC at 37°C. Finally, intracellular DC-ASGPR was localized to early endosomes, suggesting that the receptor recycles to the cell surface following internalization of ligand. Our findings identify DC-ASGPR/human macrophage lectin as a feature of immature DC, and as another lectin important for the specialized Ag-capture function of DC.
This article has been cited by other articles:
|
|
 |
|
  S T. Hollmig, K. Ariizumi, and P. D Cruz Jr Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2 Glycobiology, June 1, 2009; 19(6): 568 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Cohen, G. K. Koski, B. J. Czerniecki, K. D. Bunting, X.-Y. Fu, Z. Wang, W.-J. Zhang, C. S. Carter, M. Awad, C. A. Distel, et al. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells Blood, September 1, 2008; 112(5): 1832 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wilflingseder, Z. Banki, E. Garcia, M. Pruenster, G. Pfister, B. Muellauer, D. S. Nikolic, C. Gassner, C. G. Ammann, M. P. Dierich, et al. IgG Opsonization of HIV Impedes Provirus Formation in and Infection of Dendritic Cells and Subsequent Long-Term Transfer to T Cells J. Immunol., June 15, 2007; 178(12): 7840 - 7848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gilbert, C. Barat, R. Cantin, and M. J. Tremblay Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes J. Immunol., March 1, 2007; 178(5): 2862 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sano, K. Usami, R. Izawa, K. Denda-Nagai, N. Higashi, T. Kimura, N. Suzuki, and T. Irimura Properties of Blocking and Non-blocking Monoclonal Antibodies Specific for Human Macrophage Galactose-type C-type Lectin (MGL/ClecSF10A/CD301) J. Biochem., January 1, 2007; 141(1): 127 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhang, O. Schwartz, M. Pantelic, G. Li, Q. Knazze, C. Nobile, M. Radovich, J. He, S.-C. Hong, J. Klena, et al. DC-SIGN (CD209) recognition of Neisseria gonorrhoeae is circumvented by lipooligosaccharide variation J. Leukoc. Biol., April 1, 2006; 79(4): 731 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tyrer, A. R. Foxwell, A. W. Cripps, M. A. Apicella, and J. M. Kyd Microbial Pattern Recognition Receptors Mediate M-Cell Uptake of a Gram-Negative Bacterium Infect. Immun., January 1, 2006; 74(1): 625 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Kwan, A.-M. Helt, C. Maranon, J.-B. Barbaroux, A. Hosmalin, E. Harris, W. H. Fridman, and C. G. F. Mueller Dendritic Cell Precursors Are Permissive to Dengue Virus and Human Immunodeficiency Virus Infection J. Virol., June 15, 2005; 79(12): 7291 - 7299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. van Vliet, E. van Liempt, E. Saeland, C. A. Aarnoudse, B. Appelmelk, T. Irimura, T. B. H. Geijtenbeek, O. Blixt, R. Alvarez, I. van Die, et al. Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells Int. Immunol., May 1, 2005; 17(5): 661 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Decot, G. Woerly, M. Loyens, S. Loiseau, B. Quatannens, M. Capron, and D. Dombrowicz Heterogeneity of Expression of IgA Receptors by Human, Mouse, and Rat Eosinophils J. Immunol., January 15, 2005; 174(2): 628 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pasquier, Y. Lepelletier, C. Baude, O. Hermine, and R. C. Monteiro Differential expression and function of IgA receptors (CD89 and CD71) during maturation of dendritic cells J. Leukoc. Biol., December 1, 2004; 76(6): 1134 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Tobar, P. A. Gonzalez, and A. M. Kalergis Salmonella Escape from Antigen Presentation Can Be Overcome by Targeting Bacteria to Fc{gamma} Receptors on Dendritic Cells J. Immunol., September 15, 2004; 173(6): 4058 - 4065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Adachi, T. Ishii, Y. Ikeda, A. Hoshino, H. Tamura, J. Aketagawa, S. Tanaka, and N. Ohno Characterization of {beta}-Glucan Recognition Site on C-Type Lectin, Dectin 1 Infect. Immun., July 1, 2004; 72(7): 4159 - 4171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ebner, Z. Ehammer, S. Holzmann, P. Schwingshackl, M. Forstner, P. Stoitzner, G. M. Huemer, P. Fritsch, and N. Romani Expression of C-type lectin receptors by subsets of dendritic cells in human skin Int. Immunol., June 1, 2004; 16(6): 877 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Woltman, N. Schlagwein, S. W. van der Kooij, and C. van Kooten The Novel Cyclophilin-Binding Drug Sanglifehrin A Specifically Affects Antigen Uptake Receptor Expression and Endocytic Capacity of Human Dendritic Cells J. Immunol., May 15, 2004; 172(10): 6482 - 6489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Hart, M. D. Gunn, and S. V. Pizzo A CD91-Positive Subset of CD11c+ Blood Dendritic Cells: Characterization of the APC that Functions to Enhance Adaptive Immune Responses against CD91-Targeted Antigens J. Immunol., January 1, 2004; 172(1): 70 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bonifaz, D. Bonnyay, K. Mahnke, M. Rivera, M. C. Nussenzweig, and R. M. Steinman Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance J. Exp. Med., December 16, 2002; 196(12): 1627 - 1638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Saunier, M. Triyatni, L. Ulianich, P. Maruvada, P. Yen, and L. D. Kohn Role of the Asialoglycoprotein Receptor in Binding and Entry of Hepatitis C Virus Structural Proteins in Cultured Human Hepatocytes J. Virol., December 6, 2002; 77(1): 546 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Ryan, A. J. Marshall, D. Magaletti, H. Floyd, K. E. Draves, N. E. Olson, and E. A. Clark Dendritic Cell-Associated Lectin-1: A Novel Dendritic Cell-Associated, C-Type Lectin-Like Molecule Enhances T Cell Secretion of IL-4 J. Immunol., November 15, 2002; 169(10): 5638 - 5648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tsuiji, M. Fujimori, Y. Ohashi, N. Higashi, T. M. Onami, S. M. Hedrick, and T. Irimura Molecular Cloning and Characterization of a Novel Mouse Macrophage C-type Lectin, mMGL2, Which Has a Distinct Carbohydrate Specificity from mMGL1 J. Biol. Chem., August 2, 2002; 277(32): 28892 - 28901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. H. Geijtenbeek, A. Engering, and Y. van Kooyk DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology J. Leukoc. Biol., June 1, 2002; 71(6): 921 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Higashi, A. Morikawa, K. Fujioka, Y. Fujita, Y. Sano, M. Miyata-Takeuchi, N. Suzuki, and T. Irimura Human macrophage lectin specific for galactose/N-acetylgalactosamine is a marker for cells at an intermediate stage in their differentiation from monocytes into macrophages Int. Immunol., June 1, 2002; 14(6): 545 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iyoda, S. Shimoyama, K. Liu, Y. Omatsu, Y. Akiyama, Y. Maeda, K. Takahara, R. M. Steinman, and K. Inaba The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo J. Exp. Med., May 20, 2002; 195(10): 1289 - 1302. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
