| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Division of Immunobiology, Research Institutes of Biological Sciences, Science University of Tokyo, Chiba, Japan;
JT Pharmaceutical Frontier Research Laboratories, Inc., Kanagawa, Japan; and
Department of Medicine, Kidney Center, Tokyo Women’s Medical University, Tokyo, Japan
The functional role of inducible costimulator (ICOS)-mediated costimulation was examined in an in vivo model of alloantigen-driven Th1 or Th2 cytokine responses, the parent-into-F1 model of acute or chronic graft-vs-host disease (GVHD), respectively. When the Ab specific for mouse ICOS was injected into chronic GVHD-induced mice, activation of B cells, production of autoantibody, and development of glomerulonephritis were strongly suppressed. In contrast, the same treatment enhanced donor T cell chimerism and host B cell depletion in acute GVHD induced host mice. Blocking of B7-CD28 interaction by injection of anti-B7-1 and anti-B7-2 Abs inhibited both acute and chronic GVHD. These observations clearly indicate that the costimulatory signal mediated by CD28 caused the initial allorecognition resulting in the clonal expansion of alloreactive T cells, whereas the costimulatory signal mediated by ICOS played a critical role in the functional differentiation and manifestation of alloreactive T cells. Furthermore, treatment with anti-ICOS Ab selectively suppresses Th2-dominant autoimmune disease.
This article has been cited by other articles:
|
|
 |
|
  M. Watanabe, Y. Takagi, M. Kotani, Y. Hara, A. Inamine, K. Hayashi, S. Ogawa, K. Takeda, K. Tanabe, and R. Abe Down-Regulation of ICOS Ligand by Interaction with ICOS Functions as a Regulatory Mechanism for Immune Responses J. Immunol., April 15, 2008; 180(8): 5222 - 5234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Hurchla, J. R. Sedy, and K. M. Murphy Unexpected Role of B and T Lymphocyte Attenuator in Sustaining Cell Survival during Chronic Allostimulation J. Immunol., May 15, 2007; 178(10): 6073 - 6082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Watanabe, Y. Harada, K. Takeda, J. Takahashi, K. Ohnuki, S. Ogawa, D. Ohgai, N. Kaibara, O. Koiwai, K. Tanabe, et al. Grb2 and Gads Exhibit Different Interactions with CD28 and Play Distinct Roles in CD28-Mediated Costimulation J. Immunol., July 15, 2006; 177(2): 1085 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Z. Yu, Y. Liang, R. I. Nurieva, F. Guo, C. Anasetti, and C. Dong Opposing Effects of ICOS on Graft-versus-Host Disease Mediated by CD4 and CD8 T Cells. J. Immunol., June 15, 2006; 176(12): 7394 - 7401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Odobasic, A. R. Kitching, T. J. Semple, and S. R. Holdsworth Inducible Co-Stimulatory Molecule Ligand Is Protective during the Induction and Effector Phases of Crescentic Glomerulonephritis J. Am. Soc. Nephrol., April 1, 2006; 17(4): 1044 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Hubbard, J. M. Eng, T. Ramirez-Montagut, K. H. Tjoe, S. J. Muriglan, A. A. Kochman, T. H. Terwey, L. M. Willis, R. Schiro, G. Heller, et al. Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation Blood, November 1, 2005; 106(9): 3285 - 3292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tamura, K. Dan, K. Tamada, K. Nakamura, Y. Shioi, H. Hyodo, S.-D. Wang, H. Dong, L. Chen, and K. Ogata Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications in De novo Acute Myeloid Leukemia Clin. Cancer Res., August 15, 2005; 11(16): 5708 - 5717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Inamine, Y. Takahashi, N. Baba, K. Miyake, T. Tokuhisa, T. Takemori, and R. Abe Two waves of memory B-cell generation in the primary immune response Int. Immunol., May 1, 2005; 17(5): 581 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Taylor, A. Panoskaltsis-Mortari, G. J. Freeman, A. H. Sharpe, R. J. Noelle, A. Y. Rudensky, T. W. Mak, J. S. Serody, and B. R. Blazar Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM) Blood, April 15, 2005; 105(8): 3372 - 3380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Watanabe, Y. Hara, K. Tanabe, H. Toma, and R. Abe A distinct role for ICOS-mediated co-stimulatory signaling in CD4+ and CD8+ T cell subsets Int. Immunol., March 1, 2005; 17(3): 269 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Watanabe, S. Watanabe, Y. Hara, Y. Harada, M. Kubo, K. Tanabe, H. Toma, and R. Abe ICOS-Mediated Costimulation on Th2 Differentiation Is Achieved by the Enhancement of IL-4 Receptor-Mediated Signaling J. Immunol., February 15, 2005; 174(4): 1989 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Arimura, F. Shiroki, S. Kuwahara, H. Kato, U. Dianzani, T. Uchiyama, and J. Yagi Akt Is a Neutral Amplifier for Th Cell Differentiation J. Biol. Chem., March 19, 2004; 279(12): 11408 - 11416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Iwai, M. Abe, S. Hirose, F. Tsushima, K. Tezuka, H. Akiba, H. Yagita, K. Okumura, H. Kohsaka, N. Miyasaka, et al. Involvement of Inducible Costimulator-B7 Homologous Protein Costimulatory Pathway in Murine Lupus Nephritis J. Immunol., September 15, 2003; 171(6): 2848 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Futamatsu, J.-i. Suzuki, H. Kosuge, O. Yokoseki, M. Kamada, H. Ito, M. Inobe, M. Isobe, and T. Uede Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway Cardiovasc Res, July 1, 2003; 59(1): 95 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Wiley, S. Goncharova, T. Shea, J. R. Johnson, A. J. Coyle, and M. Jordana Evaluation of Inducible Costimulator/B7-Related Protein-1 as a Therapeutic Target in a Murine Model of Allergic Airway Inflammation Am. J. Respir. Cell Mol. Biol., June 1, 2003; 28(6): 722 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Harada, D. Ohgai, R. Watanabe, K. Okano, O. Koiwai, K. Tanabe, H. Toma, A. Altman, and R. Abe A Single Amino Acid Alteration in Cytoplasmic Domain Determines IL-2 Promoter Activation by Ligation of CD28 but Not Inducible Costimulator (ICOS) J. Exp. Med., January 20, 2003; 197(2): 257 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Iwai, Y. Kozono, S. Hirose, H. Akiba, H. Yagita, K. Okumura, H. Kohsaka, N. Miyasaka, and M. Azuma Amelioration of Collagen-Induced Arthritis by Blockade of Inducible Costimulator-B7 Homologous Protein Costimulation J. Immunol., October 15, 2002; 169(8): 4332 - 4339. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
