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The Journal of Immunology, 2001, 167: 5664-5668.
Copyright © 2001 by The American Association of Immunologists

Homeostatic Expansion Occurs Independently of Costimulatory Signals1

Martin Prlic*, Bruce R. Blazar{dagger}, Alexander Khoruts{ddagger}, Traci Zell§ and Stephen C. Jameson2,*

Departments of * Laboratory Medicine and Pathology, {dagger} Pediatrics, {ddagger} Medicine, and § Microbiology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455

Naive T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognition of specific self peptide/MHC complexes. Since costimulation signals regulate the T cell response to foreign Ags, we asked whether they also regulate homeostatic expansion. We report in this study that homeostatic expansion of CD4 and CD8 T cells occurs independently of costimulation signals mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11.10 TCR transgenic T cells, we confirmed that CD28 expression was dispensable for homeostatic expansion, and showed that the presence of endogenous CD4+CD25+ regulatory cells did not detectably influence homeostatic expansion. The implications of these findings with respect to regulation of T cell homeostasis and autoimmunity are discussed.




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