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Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
Infection of mice with the intracellular bacterium Listeria
monocytogenes results in a strong CD8+ T cell
response that is critical for efficient control of infection. We used
CD28-deficient mice to characterize the function of CD28 during
Listeria infection, with a main emphasis on
Listeria-specific CD8+ T cells. Frequencies
and effector functions of these T cells were determined using MHC class
I tetramers, single cell IFN-
production and
Listeria-specific cytotoxicity. During primary
Listeria infection of CD28-/- mice we
observed significantly reduced numbers of
Listeria-specific CD8+ T cells and only
marginal levels of specific IFN- production and cytotoxicity.
Although frequencies were also reduced in CD28-/- mice
during secondary response, we detected a considerable population of
Listeria-specific CD8+ T cells in these
mice. In parallel, IFN- production and cytotoxicity were observed,
revealing that Listeria-specific CD8+ T
cells in CD28-/- mice expressed normal effector
functions. Consistent with their impaired CD8+ T cell
activation, CD28-/- mice suffered from exacerbated
listeriosis both after primary and secondary infection. These results
demonstrate participation of CD28 signaling in the generation and
expansion of Ag-specific CD8+ T cells in listeriosis.
However, Ag-specific CD8+ T cells generated in the absence
of CD28 differentiated into normal effector and memory T
cells.
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