| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Emory Vaccine Center and Department of Microbiology and Immunology and
Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322; and
Department of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706
Although the role of CD28-B7 interaction in the activation of naive
T cells is well established, its importance in the generation and
maintenance of T cell memory is not well understood. In this study, we
examined the requirement for CD28-B7 interactions in primary T cell
activation and immune memory. Ag-specific CD8 T cell responses were
compared between wild-type (+/+) and CD28-deficient
(CD28-/-) mice following an acute infection with
lymphocytic choriomeningitis virus (LCMV). During the primary response,
there was a substantial activation and expansion of LCMV-specific CD8 T
cells in both +/+ and CD28-/- mice. However, the
magnitude of the primary CD8 T cell response to both dominant and
subdominant LCMV CTL epitopes was 
2- to 3-fold lower in
CD28-/- mice compared with +/+ mice; the lack of
CD28-mediated costimulation did not lead to preferential suppression of
CD8 T cell responses to the weaker subdominant epitopes. As seen in
CD28-/- mice, blockade of B7-mediated costimulation by
CTLA4-Ig treatment of +/+ mice also resulted in a 2-fold reduction in
the anti-LCMV CD8 T cell responses. Loss of CD28/B7 interactions
did not significantly affect the generation and maintenance of CD8 T
cell memory; the magnitude of CD8 T cell memory was 2-fold lower in
CD28-/- mice as compared with +/+ mice. Further, in
CD28-/- mice, LCMV-specific memory CD8 T cells showed
normal homeostatic proliferation in vivo and also conferred protective
immunity. Therefore, CD28 signaling is not necessary for the
proliferative renewal and maintenance of memory CD8 T
cells.
This article has been cited by other articles:
|
|
 |
|
  L. Garidou, S. Heydari, P. Truong, D. G. Brooks, and D. B. McGavern Therapeutic Memory T Cells Require Costimulation for Effective Clearance of a Persistent Viral Infection J. Virol., September 1, 2009; 83(17): 8905 - 8915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Alcazar, I. Cortes, A. Zaballos, C. Hernandez, D. A. Fruman, D. F. Barber, and A. C. Carrera p85{beta} phosphoinositide 3-kinase regulates CD28 coreceptor function Blood, April 2, 2009; 113(14): 3198 - 3208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Salek-Ardakani, R. Arens, R. Flynn, A. Sette, S. P. Schoenberger, and M. Croft Preferential Use of B7.2 and Not B7.1 in Priming of Vaccinia Virus-Specific CD8 T Cells J. Immunol., March 1, 2009; 182(5): 2909 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Vagvala, L. G. Thebeau, S. R. Wilson, and L. A. Morrison Virus-Encoded B7-2 Costimulation Molecules Enhance the Protective Capacity of a Replication-Defective Herpes Simplex Virus Type 2 Vaccine in Immunocompetent Mice J. Virol., January 15, 2009; 83(2): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Umeshappa, H. Huang, Y. Xie, Y. Wei, S. J. Mulligan, Y. Deng, and J. Xiang CD4+ Th-APC with Acquired Peptide/MHC Class I and II Complexes Stimulate Type 1 Helper CD4+ and Central Memory CD8+ T Cell Responses J. Immunol., January 1, 2009; 182(1): 193 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. J. Kraus, J. S. Haring, and G. A. Bishop TNF Receptor-Associated Factor 5 Is Required for Optimal T Cell Expansion and Survival in Response to Infection J. Immunol., December 1, 2008; 181(11): 7800 - 7809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Salek-Ardakani, M. Moutaftsi, S. Crotty, A. Sette, and M. Croft OX40 Drives Protective Vaccinia Virus-Specific CD8 T Cells J. Immunol., December 1, 2008; 181(11): 7969 - 7976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-Y. Wang, E. B. Olson Jr., D. E. Bjorling, G. S. Mitchell, and G. E. Bisgard Sustained hypoxia-induced proliferation of carotid body type I cells in rats J Appl Physiol, March 1, 2008; 104(3): 803 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fuse, W. Zhang, and E. J. Usherwood Control of Memory CD8+ T Cell Differentiation by CD80/CD86-CD28 Costimulation and Restoration by IL-2 during the Recall Response J. Immunol., January 15, 2008; 180(2): 1148 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Thebeau, S. P. Vagvala, Y. M. Wong, and L. A. Morrison B7 Costimulation Molecules Expressed from the Herpes Simplex Virus 2 Genome Rescue Immune Induction in B7-Deficient Mice J. Virol., November 15, 2007; 81(22): 12200 - 12209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Borowski, A. C. Boesteanu, Y. M. Mueller, C. Carafides, D. J. Topham, J. D. Altman, S. R. Jennings, and P. D. Katsikis Memory CD8+ T Cells Require CD28 Costimulation J. Immunol., November 15, 2007; 179(10): 6494 - 6503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tewari, Y. Nakayama, and M. Suresh Role of Direct Effects of IFN-{gamma} on T Cells in the Regulation of CD8 T Cell Homeostasis J. Immunol., August 15, 2007; 179(4): 2115 - 2125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Valujskikh and X. C. Li Frontiers in Nephrology: T Cell Memory as a Barrier to Transplant Tolerance J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2252 - 2261. [Full Text] [PDF]
|
|
|
|
 |
|
 H.-P. Raue and M. K. Slifka Pivotal Advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection J. Leukoc. Biol., May 1, 2007; 81(5): 1165 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Ndejembi, J. R. Teijaro, D. S. Patke, A. W. Bingaman, M. R. Chandok, A. Azimzadeh, S. G. Nadler, and D. L. Farber Control of Memory CD4 T Cell Recall by the CD28/B7 Costimulatory Pathway J. Immunol., December 1, 2006; 177(11): 7698 - 7706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fang and L. J. Sigal Direct CD28 Costimulation Is Required for CD8+ T Cell-Mediated Resistance to an Acute Viral Disease in a Natural Host J. Immunol., December 1, 2006; 177(11): 8027 - 8036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Prlic, G. Hernandez-Hoyos, and M. J. Bevan Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response J. Exp. Med., September 4, 2006; 203(9): 2135 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fuse, J. J. Obar, S. Bellfy, E. K. Leung, W. Zhang, and E. J. Usherwood CD80 and CD86 Control Antiviral CD8+ T-Cell Function and Immune Surveillance of Murine Gammaherpesvirus 68. J. Virol., September 1, 2006; 80(18): 9159 - 9170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Meng, H. Harlin, J. P. O'Keefe, and T. F. Gajewski Induction of Cytotoxic Granules in Human Memory CD8+ T Cell Subsets Requires Cell Cycle Progression J. Immunol., August 1, 2006; 177(3): 1981 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. York, M. A. Brehm, S. Zendzian, C. F. Towne, and K. L. Rock Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance PNAS, June 13, 2006; 103(24): 9202 - 9207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Kemball, E. D. H. Lee, E. Szomolanyi-Tsuda, T. C. Pearson, C. P. Larsen, and A. E. Lukacher Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection J. Immunol., February 1, 2006; 176(3): 1814 - 1824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wuthrich, T. Warner, and B. S. Klein CD28 Is Required for Optimal Induction, but Not Maintenance, of Vaccine-Induced Immunity to Blastomyces dermatitidis Infect. Immun., November 1, 2005; 73(11): 7436 - 7441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Song, X. Tang, K. M. Harms, and M. Croft OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen J. Immunol., September 15, 2005; 175(6): 3534 - 3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-A. M. Pozzi, J. W. Maciaszek, and K. L. Rock Both Dendritic Cells and Macrophages Can Stimulate Naive CD8 T Cells In Vivo to Proliferate, Develop Effector Function, and Differentiate into Memory Cells J. Immunol., August 15, 2005; 175(4): 2071 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yamada, A. D. Salama, M. Sho, N. Najafian, T. Ito, J. P. Forman, R. Kewalramani, S. Sandner, H. Harada, M. R. Clarkson, et al. CD70 Signaling Is Critical for CD28-Independent CD8+ T Cell-Mediated Alloimmune Responses In Vivo J. Immunol., February 1, 2005; 174(3): 1357 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suresh, A. Singh, and C. Fischer Role of Tumor Necrosis Factor Receptors in Regulating CD8 T-Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection J. Virol., January 1, 2005; 79(1): 202 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Williams and M. J. Bevan Shortening the Infectious Period Does Not Alter Expansion of CD8 T Cells but Diminishes Their Capacity to Differentiate into Memory Cells J. Immunol., December 1, 2004; 173(11): 6694 - 6702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, K. Doffek, S. L. Sugg, and J. Shilyansky Phosphatidylserine Regulates the Maturation of Human Dendritic Cells J. Immunol., September 1, 2004; 173(5): 2985 - 2994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Vu, F. Amanullah, Y. Li, G. Demirci, M. H. Sayegh, and X. C. Li Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection J. Immunol., July 1, 2004; 173(1): 214 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Wherry and R. Ahmed Memory CD8 T-Cell Differentiation during Viral Infection J. Virol., June 1, 2004; 78(11): 5535 - 5545. [Full Text] [PDF]
|
|
|
|
|
|
A. E. Juedes, E. Rodrigo, L. Togher, L. H. Glimcher, and M. G. von Herrath T-bet Controls Autoaggressive CD8 Lymphocyte Responses in Type 1 Diabetes J. Exp. Med., April 19, 2004; 199(8): 1153 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hendriks, Y. Xiao, and J. Borst CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool J. Exp. Med., November 3, 2003; 198(9): 1369 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Nayak, G. Sailaja, and A. M. Jabbar Enhancement of gp120-Specific Immune Responses by Genetic Vaccination with the Human Immunodeficiency Virus Type 1 Envelope Gene Fused to the Gene Coding for Soluble CTLA4 J. Virol., October 15, 2003; 77(20): 10850 - 10861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Amyes, C. Hatton, D. Montamat-Sicotte, N. Gudgeon, A. B. Rickinson, A. J. McMichael, and M. F.C. Callan Characterization of the CD4+ T Cell Response to Epstein-Barr Virus during Primary and Persistent Infection J. Exp. Med., September 15, 2003; 198(6): 903 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Lakkis and M. H. Sayegh Memory T Cells: A Hurdle to Immunologic Tolerance J. Am. Soc. Nephrol., September 1, 2003; 14(9): 2402 - 2410. [Full Text] [PDF]
|
|
|
|
|
|
C. H. Maris, J. D. Miller, J. D. Altman, and J. Jacob A Transgenic Mouse Model Genetically Tags All Activated CD8 T Cells J. Immunol., September 1, 2003; 171(5): 2393 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Eshima, Y. Choi, and R. A. Flavell CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A Int. Immunol., July 1, 2003; 15(7): 817 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Miyahira, M. Katae, S. Kobayashi, T. Takeuchi, Y. Fukuchi, R. Abe, K. Okumura, H. Yagita, and T. Aoki Critical Contribution of CD28-CD80/CD86 Costimulatory Pathway to Protection from Trypanosoma cruzi Infection Infect. Immun., June 1, 2003; 71(6): 3131 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Miyahira, M. Katae, K. Takeda, H. Yagita, K. Okumura, S. Kobayashi, T. Takeuchi, T. Kamiyama, Y. Fukuchi, and T. Aoki Activation of Natural Killer T Cells by {alpha}-Galactosylceramide Impairs DNA Vaccine-Induced Protective Immunity against Trypanosoma cruzi Infect. Immun., March 1, 2003; 71(3): 1234 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Thebeau and L. A. Morrison Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation J. Virol., February 15, 2003; 77(4): 2426 - 2435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suresh, H. Molina, M. S. Salvato, D. Mastellos, J. D. Lambris, and M. Sandor Complement Component 3 Is Required for Optimal Expansion of CD8 T Cells During a Systemic Viral Infection J. Immunol., January 15, 2003; 170(2): 788 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Vacchio and R. J. Hodes CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells J. Exp. Med., January 6, 2003; 197(1): 19 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Ekkens, Z. Liu, Q. Liu, J. Whitmire, S. Xiao, A. Foster, J. Pesce, J. VanNoy, A. H. Sharpe, J. F. Urban, et al. The Role of OX40 Ligand Interactions in the Development of the Th2 Response to the Gastrointestinal Nematode Parasite Heligmosomoides polygyrus J. Immunol., January 1, 2003; 170(1): 384 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Montagnoli, A. Bacci, S. Bozza, R. Gaziano, P. Mosci, A. H. Sharpe, and L. Romani B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans J. Immunol., December 1, 2002; 169(11): 6298 - 6308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Cheng and P. D. Greenberg Selective Delivery of Augmented IL-2 Receptor Signals to Responding CD8+ T Cells Increases the Size of the Acute Antiviral Response and of the Resulting Memory T Cell Pool J. Immunol., November 1, 2002; 169(9): 4990 - 4997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Prilliman, E. E. Lemmens, G. Palioungas, T. G. Wolfe, J. P. Allison, A. H. Sharpe, and S. P. Schoenberger Cutting Edge: A Crucial Role for B7-CD28 in Transmitting T Help from APC to CTL J. Immunol., October 15, 2002; 169(8): 4094 - 4097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Becker, E. J. Wherry, D. Boone, K. Murali-Krishna, R. Antia, A. Ma, and R. Ahmed Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells J. Exp. Med., June 17, 2002; 195(12): 1541 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Ekkens, Z. Liu, Q. Liu, A. Foster, J. Whitmire, J. Pesce, A. H. Sharpe, J. F. Urban, and W. C. Gause Memory Th2 Effector Cells Can Develop in the Absence of B7-1/B7-2, CD28 Interactions, and Effector Th Cells After Priming with an Intestinal Nematode Parasite J. Immunol., June 15, 2002; 168(12): 6344 - 6351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Bertram, P. Lau, and T. H. Watts Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection J. Immunol., April 15, 2002; 168(8): 3777 - 3785. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
