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Cutting Edge |
*
Department of Pathology, University of Cambridge, Cambridge, United Kingdom; and
Discovery Research, GlaxoSmithKline, Stevenage, United Kingdom
We studied recognition of the disease-associated HLA-B27
allele by immunomodulatory receptors encoded within the
leukocyte receptor complex. HLA class I are ligands for members of the
killer Ig receptor (KIR) and Ig-like transcript (ILT)/LIR/LILR families
(the new LILR nomenclature is described at
www. gene.ucl.ac.uk/nomenclature/genefamily/lilr.html). Members of
these families bound HLA-B27 in both classical and 
2
microglobulin-independent forms. Classical complexes bound ILT2,
ILT4, and LIR6 transfectants but not ILT1, ILT3, or ILT5. A free H
chain form of HLA-B27 bound ILT4 and LIR6. Both forms of HLA-B27 bound
KIR3DL1 transfectants. HLA-B27 free H chain bound CD14+
cells in PBL from healthy controls, consistent with ILT4 expression on
monocytes. Alternative recognition of different forms of HLA-B27 by KIR
or ILT could influence their immunomodulatory function and may imply a
role in inflammatory disease.
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